A5020957761- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Lymphoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Ear and Head Tumors
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- RNA modifications and cancer
- Inflammatory Biomarkers in Disease Prognosis
- Sinusitis and nasal conditions
- Nutrition and Health in Aging
- Water resources management and optimization
- Chromatin Remodeling and Cancer
- Ocular Oncology and Treatments
- Water-Energy-Food Nexus Studies
- Angiogenesis and VEGF in Cancer
- Lymphatic Disorders and Treatments
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
Eye & ENT Hospital of Fudan University
2019-2025
Fudan University
2016-2024
Shandong University
2024
Fudan University Shanghai Cancer Center
2010-2021
Shanghai Medical College of Fudan University
2011-2021
Shandong Provincial Hospital
2020
Shandong First Medical University
2020
Shanghai Jiao Tong University
2010
Angiogenesis is an important process in cell development, especially cancer. Vascular endothelial growth factor (VEGF) signaling regulator of angiogenesis. Several therapies that act against VEGF signal transduction have been developed, including YN968D1, which a potent inhibitor the pathway. This study investigated antitumor activity YN968D1 (apatinib mesylate) vitro and vivo . potently suppressed kinase activities VEGFR‐2, c‐kit c‐src, inhibited cellular phosphorylation PDGFRβ. effectively...
This phase II trial aimed to determine the efficacy and safety of induction chemoimmunotherapy camrelizumab plus modified TPF in locally advanced hypopharyngeal squamous cell carcinoma (LA HSCC) (NCT04156698). The primary endpoint was objective response rate (ORR), secondary endpoints were 3-year overall survival (OS), progression-free (PFS), larynx preservation (LPR), metastasis-free (MFS). Patients (cT3-4aN0-2M0), regardless sex, received for three cycles: 200 mg d1, docetaxel 75 mg/m
Abstract Background Cancer cells induce the infiltration of various immune that are located or distributed in different sites and play multiple roles, which have recently been proposed to predict clinical outcomes. We therefore studied prognostic significance presence tumour-infiltrating lymphocytes (TILs) ratios between types hypopharyngeal squamous cell carcinoma (HPSCC). Methods retrospectively analysed 132 consecutive patients diagnosed with advanced HPSCC 2013–2017. Tumoural parenchyma...
Hypopharyngeal squamous-cell carcinoma (HSCC) is a relatively rare head and neck cancer, with great variation in patient outcomes. This study aimed to develop prognostic nomogram for patients HSCC. From the Surveillance, Epidemiology, End Results (SEER) database, we retrieved clinical data of 2198 diagnosed HSCC between 2010 2016. The were randomly assigned at 4:1 ratio training set or validation set. An external was performed by 233 locally advanced treated our center. A Cox proportional...
Abstract Background Previous studies have investigated the value of induction chemotherapy (IC) in organ preservation strategies for head and neck cancers. This study evaluated effectiveness sequential IC with radiotherapy as a laryngeal strategy locally advanced hypopharyngeal carcinoma (LAHSCC). Methods One hundred forty‐two consecutive patients LAHSCC were retrospectively analyzed who received three regimens from 2015 to 2019. Results In TP (docetaxel plus cisplatin), TPF (TP...
Abstract The effects of the Rashba spin-orbit interaction and external electric magnetic fields on thermodynamic properties parabolic quantum dots are investigated. An explicit partition function is derived, quantities, including specific heat, entropy, susceptibility, analyzed. behavior Shannon entropy-related quantities examined under varying Hamiltonian parameters through numerical analysis. results reveal a pronounced Schottky anomaly in heat capacity at lower temperatures....
The aim was to assess the diagnostic accuracy of four different nutrition screening and evaluation instruments in nasopharyngeal carcinoma patients, benchmarked against Global Leadership Initiative on Malnutrition (GLIM) criteria. An observational, single-institution study conducted between June 2022 May 2023. Nutrition status assessed using Nutritional Risk Screening 2002 (NRS-2002), Universal Tool (MUST), (MST), Patient-Generated Subjective Assessment (PG-SGA), GLIM criteria at two time...
There is a scarcity of data about the prognostic value orbital invasion in esthesioneuroblastoma (ENB), as well its management strategies. Indications for preservation contents remain controversial, and evaluation has been ill defined. This retrospective analysis contained 60 ENB patients with who underwent radiotherapy or without surgery over past 14 years. Orbital was classified into three grades. were 52 at stage C 8 D, according to Foote classifications. Grade I, grade II III detected...
This study was intended to review our management strategy for sinonasal squamous cell carcinomas (SNSCCs) with orbital invasion and explore the role of radiotherapy in preservation.We retrospectively analyzed 93 SNSCC patients who underwent or without surgery over past 15 years. The degree classified into 3 grades.Eighty-eight presented T4 tumors 36 had grade III invasion. Seventy-two received plus radiation 67 platinum-based chemotherapy. median follow-up surviving 60 months. Five-year...
Gastric cancer (GC) is lethal and there an urgent need for improved understanding of this disease. Recent studies have reported that microRNAs (miRNAs) play increasingly important roles in the regulation GC. In study, we explored target genes effects miR-7641 Our data showed high expression was associated with low ARID1A GC tissue. promoted cell proliferation colony formation. Luciferase reporter assay results confirmed a gene miR-7641. Furthermore, downregulation caused significant increase...
Abstract Extranodal natural killer/T‐cell lymphoma (ENKL), nasal‐type is a rare but highly aggressive disease with poor prognosis. Optimal treatment strategies for newly diagnosed localized ENKL have not been fully defined. Here we retrospectively analyzed 72 patients stage IE/IIE treated gemcitabine, dexamethasone, and cisplatin (GDP) regimen chemotherapy sandwiched radiotherapy in our department between May 2012 September 2014. After 2 cycles of GDP induction chemotherapy, the complete...
Summary Early‐stage natural killer/T‐cell lymphoma (NK/TCL) patients usually receive a combination of chemotherapy and radiotherapy, but the optimal treatment approach has not yet been established. This study aimed to investigate efficacy safety profile novel regimen sandwiched radiotherapy in early‐stage NK/TCL. Patients with newly diagnosed stage IE/IIE disease were eligible. initially treated two courses GELAD (gemcitabine 1·0 g/m 2 day 1, etoposide 60 mg/m days 1–3, pegaspargase 2000...
Optimal treatment strategies for natural killer/T-cell lymphoma (NKTCL) patients with stage IV disease have not been well defined. In this prospective phase 2 study, we evaluated the using MEDA (methotrexate, etoposide, dexamethasone and pegaspargase) as induction chemotherapy autologous hematopoietic stem cell transplantation (Auto-HSCT) consolidation. Patients without prior L-asparaginase-based were eligible. Four cycles of administered treatment. complete response (CR, necessary to...
Abstract Background microRNAs (miRNAs) play essential roles in the development and progression of gastric cancer (GC). Although aberrant miR-874 expression has been reported various human cancers, its role GC remains obscure. Methods was assessed by real-time quantitative polymerase chain reaction (RT-qPCR) 62 matched adjacent normal tissues, as well cell lines immortalized epithelial cells. CCK8 assay, colony formation flow cytometry were used to assess proliferation apoptosis vitro....
Background: There is an urgent need to identify which patients would benefit from TPF chemotherapy in hypopharyngeal squamous cell carcinoma (HPSCC) and explore new combinations improve the treatment effect. Materials methods: Gene-expression profiles 15 TPF-sensitive were compared 13 resistant patients. Immunohistochemistry (IHC) was performed detect CD8+ T cells 28 samples. Patient-Derived Tumor Xenograft (PDX) model IHC used verify markers that optimize for HPSCC. Results: Through RNA...