A5072292376- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Treatment and Pharmacology
- Frailty in Older Adults
- Angiogenesis and VEGF in Cancer
- Estrogen and related hormone effects
- Urologic and reproductive health conditions
- Testicular diseases and treatments
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound and Hyperthermia Applications
- Cell Adhesion Molecules Research
- Dermatological and Skeletal Disorders
- Kidney Stones and Urolithiasis Treatments
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- Microbial metabolism and enzyme function
- Pediatric Hepatobiliary Diseases and Treatments
- Genetic factors in colorectal cancer
McGill University Health Centre
2019-2022
McGill University
2017-2020
Medical University of South Carolina
2012
New York City College of Technology
2010
Colorectal cancer liver metastases (CRCLM) that present with a replacement histopathological growth pattern (HGP) are resistant to neoadjuvant anti-angiogenic therapy. Surrogate biomarkers not available preoperatively identify patients these tumors. Here we differentially expressed genes between CRCLM HGP and those desmoplastic using RNA sequencing. We demonstrate LOXL4 is transcriptionally upregulated in compared the adjacent normal liver. Interestingly, lysyl oxidase-like 4 (LOXL4) protein...
Abstract Claudin-2 promotes breast cancer liver metastasis by enabling seeding and early cell survival. We now demonstrate that is functionally required for colorectal expression in primary cancers associated with poor overall metastasis-free have examined the role of Claudin-2, other claudin family members, as potential prognostic biomarkers desmoplastic replacement histopathological growth pattern metastases. Immunohistochemical analysis revealed higher levels type metastases when compared...
ABSTRACT Background and Objectives: EUS-guided biliary drainage (EUS-BD) is a promising alternative to ERCP in malignant distal obstruction (MDBO). Despite accumulating data, however, its application clinical practice has been impeded by undefined barriers. This study aims evaluate the of EUS-BD Methods: An online survey was generated using Google Forms. Six gastroenterology/endoscopy associations were contacted between July 2019 November 2019. Survey questions measured participant...
Abstract African Americans (AA) have worse stage-specific survival from colorectal cancer (CRC) compared to European (EA), but the reasons for these differences are not well understood. To address this gap in understanding, and examine racial of patients with metastatic adenocarcinoma (mCRC) by age prognostic tumor characteristics, we analyzed clinical data Hollings Cancer Center (HCC) at Medical University South Carolina. Because disease has standard recommendations, a large difference...
Our previous studies have shown that estrogen is involved in the neuroprotection of cells under hypoglycemic conditions within 24 hrs. The hypothalamic (N38) were treated various (T1‐ media with 5%FBS and 1% Pen‐Strep at hrs, T2‐ T1without glucose T3‐ T1 without 100 micro M estrogen, T4‐ 72 T5‐ T2 72hrs, T6‐ T3 hrs.). One possible pathway through which exerts its protection Akt‐GSK coupling. Akt regulates cell survival by phosphorylating components death apparatus like glycogen synthase...
Abstract Colorectal cancer (CRC) is the third most common in North America, and leading cause of cancer-related death. About 50% patients will be diagnosed with CRC liver metastasis (CRCLM) during course their disease. We have identified two major histological growth patterns (HGP) CRCLM resected from patients. In desmoplastic HGP (DHGP), tumor cells are enclosed within a stromal ring, physically separating them normal tissue. replacement (RHGP), replace hepatocytes without disrupting...
A 28-year-old man previously diagnosed and treated for testicular sex cord-stromal tumour (TSCST) presented with symptoms of fever, night sweats fatigue. Following initial investigations an infectious aetiology, imaging studies detected two large liver lesions. Histopathological assessment the tumours revealed that they were metastases from TSCST which patient had radical inguinal orchiectomy retroperitoneal lymph node dissection 5 years prior. The curative-intent management bilobar...
Three different histopathological growth patterns (HGP) have been identified in colorectal cancer liver metastases (CRCLM) resected from patients: the desmoplastic HGP, pushing and replacement HGP. Evidence suggests that predominant pattern with which a CRCLM presents has clinically relevant prognostic implications. We shown patients HGP lesions who received bevacizumab plus chemotherapy had worse pathological response five-year overall survival than those receiving same treatment. also...
Abstract Background Endoscopic ultrasound-guided biliary drainage (EUS-BD) is a promising alternative to endoscopic retrograde cholangiopancreatography (ERCP) in malignant distal obstruction (MDBO). Recent small randomized controlled trials comparing EUS-BD with ERCP suggest that achieves similar technical success rate and safety profile while potentially being associated lower rates of stent dysfunction However, its application clinical practice has been impeded by various undefined...