A5101616241- Neonatal and Maternal Infections
- Microbial bioremediation and biosurfactants
- Aquaculture disease management and microbiota
- Pesticide and Herbicide Environmental Studies
- Vibrio bacteria research studies
- Clostridium difficile and Clostridium perfringens research
- Cytomegalovirus and herpesvirus research
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- interferon and immune responses
- Minerals Flotation and Separation Techniques
- Influenza Virus Research Studies
- Human Mobility and Location-Based Analysis
- Membrane Separation Technologies
- Machine Learning in Materials Science
- Telomeres, Telomerase, and Senescence
- Inflammatory Bowel Disease
- Alzheimer's disease research and treatments
- Bariatric Surgery and Outcomes
- Viral-associated cancers and disorders
- Transportation Planning and Optimization
- Phytochemistry and biological activity of medicinal plants
- Corneal surgery and disorders
- Gastric Cancer Management and Outcomes
- Computational Drug Discovery Methods
Sun Yat-sen University
2013-2024
East China University of Science and Technology
2023-2024
The Third People's Hospital of Dalian City
2024
Chinese Academy of Sciences
2006-2008
Institute of Zoology
2006-2008
China Agricultural University
2008
We report our discovery of a novel series potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors. Starting from lead identified by scaffold-hopping approach, development efforts were focused on exploring structure-activity relationships, optimizing pharmacokinetic profile, improving in vitro vivo efficacy, evaluating safety profile. The selected candidate, Imigliptin, is now undergoing clinical trial.
ABSTRACT Instances of drug‐resistant tuberculosis (TB), particularly multidrug‐ and extensive TB, are escalating worldwide; therefore, there is an urgent need to explore suitable treatment strategies. This study assessed the precision matrix‐assisted laser desorption‐ionisation time‐of‐flight mass spectrometry (MALDI‐TOF MS) in detecting TB. We developed a multiplex MALDI‐TOF MS detection assay that concurrently identifies 51 gene mutations for six commonly used medications: rifampicin...
Mycobacterium tuberculosis antimicrobial resistance has been continually reported and is a major public health issue worldwide. Rapid prediction of drug important for selecting appropriate antibiotic treatments, which significantly increases cure rates. Gene sequencing technology proven to be powerful strategy identifying relevant information. This study established method bioinformatics pipeline gene analysis using an Oxford Nanopore Technologies sequencer. The was validated by Sanger...
Background This study aims to investigate the independent causal relation between height, screen time, physical activity, sleep and myopia. Methods Instrumental variables (IVs) for exposures outcome were obtained from largest publicly available genome-wide association studies (GWAS) databases. First, we performed a bidirectional univariate MR analysis using primarily inverse variance weighted method (IVW) with activity as exposure myopia relationship Sensitivity was used demonstrate its...
Influenza virus causes high morbidity among the infected population annually and occasionally spread of pandemics. Melaleuca alternifolia Concentrate (MAC) is an essential oil derived from a native Australian tea tree. Our aim was to investigate whether MAC has any in vitro inhibitory effect on influenza infection what mechanism does use fight infection. In this study, antiviral activity examined by its inhibition cytopathic effects. silico prediction performed evaluate interaction between...
APE1 is a multifunctional protein with DNA base excision repair function in its C-terminal domain and redox activity N-terminal domain. The of converts certain transcription factors from inactive oxidized to active reduced forms. Given that among the APE1-regulated many are critical for KSHV replication pathogenesis, we investigated whether inhibition blocks Kaposi's sarcoma (KS) phenotypes. With an shRNA-mediated silencing approach known APE-1 inhibitor, demonstrated indeed required as well...
Streptococcus agalactiae is an important pathogen in fish, causing great losses of intensive tilapia farming. To develop a potential live attenuated vaccine, re-attenuated S. (named TFJ-ery) was developed from natural low-virulence strain TFJ0901 through selection resistance to erythromycin. The biological characteristics, virulence, stability and the immunization protective efficacy TFJ-ery were determined. results indicated that grew at slower rate than TFJ0901. capsule thickness...
Abstract Identifying novel drug-protein interactions is crucial for drug discovery. For this purpose, many machine learning-based methods have been developed based on descriptors and one-dimensional (1D) protein sequences. However, sequence can’t accurately reflect the in 3D space. On other hand, a direct input of structure low efficiency due to sparse matrix, also prevented by limited number co-crystal structures available training. In work, we propose an end-to-end deep learning framework...
Streptococcus agalactiae is a major pathogen of tilapia causing significant economic losses for the global aquatic industry yearly. To elucidate role cel-EIIB protein-mediated phosphotransferase systems (PTS) in virulence regulation S. agalactiae, gene deletion virulent strain THN0901 was achieved by homologous recombination. The cellobiose utilization △cel-EIIB significantly decreased relative to S.a.THN0901 incubating LB with 10 mg/ml (p < 0.05). biofilm formation ability also when...
The aims of the study were to evaluate whether epidemic strains streptococcosis infected tilapia can be isolated and identified from dead fish for epidemiological investigation. Firstly, tilapias inoculated with a lethal dose (1 × 108 CFU per fish) Streptococcus agalactiae brain tissues harvested bacteriological examination qPCR assay 3, 12, 24 48 h postdeath. was only dominant bacterium cultivated on heart infusion (BHI) plate bacterial load about 107 mg. Secondly, killed via ice water...
Abstract Most well sites have discontinued using the associated gas-fired furnaces in response to current situation oil fields. Coal-fired heating are environmentally polluting and prohibited due local environmental regulations. These two methods can cause high costs, poor efficiency, pollution, which cannot be achieved through remote digital monitoring. Research has been conducted on electromagnetic device for crude site, focusing introducing its main components functions, including body,...