A5102749841- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- HIV, Drug Use, Sexual Risk
- SARS-CoV-2 detection and testing
- Poverty, Education, and Child Welfare
- Cardiovascular Health and Risk Factors
- SARS-CoV-2 and COVID-19 Research
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Impact and Responses
- Hepatitis B Virus Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Influenza Virus Research Studies
- Genital Health and Disease
- Viral gastroenteritis research and epidemiology
- Heart Rate Variability and Autonomic Control
- Viral Infections and Immunology Research
- Early Childhood Education and Development
- Cardiac Health and Mental Health
University of the Witwatersrand
2019-2024
Perinatal HIV Research Unit
2024
Utrecht University
2024
Right to Care
2013-2017
University of Limpopo
2011
University of Mpumalanga
2008
The COVID-19 pandemic has caused millions of infections and deaths resulted in unprecedented international public health social economic crises. As SARS-CoV-2 spread across the globe its impact became evident, development safe effective vaccines a priority. Outlining processes used to establish support conduct phase 3 randomized clinical trials that led rapid emergency use authorization approval several is major significance for current future response efforts.
Uptake of antiretroviral treatment (ART) is expanding rapidly in low- and middle-income countries (LMIC). Monitoring virological suppression recommended at 6 months annually thereafter. In case confirmed failure, a switch to second-line ART indicated. There paucity data on clinical management patients experiencing viremia practice LMIC. We report large-scale multicenter assessment over time under programmatic conditions.Linked medical record laboratory source from adult first-line 52 South...
Hypertension is one of the most important risk factors for cardiovascular disease and has a high prevalence in South Africa other low- middle-income countries. However, awareness hypertension been reported to be low. Health programmes can increase its causes, but hinge on knowledge perception targeted community. Therefore, this study investigated perceptions about community members rural area Limpopo, with aim local population. Using mixed methods approach, 451 participants Ndlovu Cohort...
In a large cohort in rural South Africa, 73% of subtype-C-infected patients initiating highly active antiretroviral therapy achieved viral suppression. with subsequent virological failure, an unexpected, rapid accumulation nonnucleoside reverse transcriptase inhibitor-associated mutations was observed, whereas no thymidine analogue-associated emerged. It appeared that several had drug-associated prior to starting antiretrovirals, suggesting transmission resistance may have contributed the...
The purpose of this study was to assess the one-year efficacy highly active antiretroviral therapy (HAART) administered by general practitioners in a primary care community clinic rural South Africa. We performed an observational cohort 675 treatment-naive human immunodeficiency virus (HIV)-infected patients (including 66 children) who began HAART at least 12 months prior data analyses. Throughout treatment, CD4+ T-cell count (percentage T-cells and plasma HIV-RNA level were determined...
Background. In sub-Saharan Africa, the number of persons living with human immunodeficiency virus (HIV) has increased immensely. parallel, rates noncommunicable diseases, especially cardiovascular disease, are rising rapidly in resource-limited settings. This study aims to evaluate relation between subclinical atherosclerosis and HIV-related traditional risk factors HIV-infected patients rural South Africa.
HIV majorly contributes to the disease burden in South Africa. Depressive symptoms are common people living with (PLHIV). Few studies compared depressive between PLHIV and those without HIV. The aim of study was examine association status symptoms. Moreover, aimed explore comparison HIV-negative participants different HIV-positive sub-groups regarding their A cross-sectional analysis conducted among rural Africa, using baseline data Ndlovu Cohort study. Data collected on demographics,...
Introduction: HIV/AIDS continues to be a significant health issue in Sub-Saharan Africa, with stigma likely affecting ART adherence, and subsequently viremia, inflammation, cardiovascular disease (CVD). We investigated the association between stigma, CVD risk among people living HIV (PLWH). Setting: A longitudinal study was conducted 325 PLWH from Ndlovu Cohort Study, South Africa. Methods: Stigma assessed using 12-item questionnaire (range: 0-44; higher scores indicate greater stigma)....
Objective. To define the long-term (2-4 years) clinical and virological outcome of an antiretroviral treatment (ART) programme in rural South Africa. Methods. We performed a retrospective observational cohort study, including 735 patients who initiated ART. Biannual monitoring, HIV-RNA testing, was performed. Primary endpoint patient retention; suppression (HIV-RNA < 50 copies/mL) failure > 1000 were secondary endpoints. Moreover, possible predictors analyzed. Results. 63% (466/735) have...
Abstract Human immunodeficiency (HIV), hepatitis B (HBV), and C (HCV) viruses are endemic in Sub‐Saharan Africa, but data regarding the prevalence of co‐infections HIV‐positive individuals residing there limited. The aim study was to determine HBV, HCV, occult HBV (presence HBV‐DNA absence HBsAg) a rural, South African cohort. results were compared various ethnic groups Dutch cohort people infected with HIV. Antiretroviral‐naïve HIV from both rural clinic (n = 258), University hospital 782),...
Background The largest proportion of people living with HIV resides in sub-Saharan Africa (SSA). Evidence from developed countries suggests that infection increases the relative risk cardiovascular disease (CVD) by up to 50%. Differences lifestyle, gender distribution, routes transmission and subtype preclude generalisation data Western SSA situation. Ndlovu Cohort Study aims provide insight into burden factors disease, mechanisms driving CVD contribution its treatment development a rural...
Background HIV is associated with an increased risk of cardiovascular disease (CVD) in high-income countries. Little known about the CVD burden sub-Saharan Africa, where 70% world's HIV-positive population lives. This study aims to provide insight into a rural setting Africa considering infection and antiretroviral therapy (ART). Methods Results A cross-sectional analysis was conducted baseline Ndlovu Cohort including HIV-negative participants South between 2014 2017. Information collected...
The rapid emergence and spread of numerous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants across the globe underscores crucial need for continuous SARS-CoV-2 surveillance to ensure that potentially more pathogenic are detected early contained. Whole genome sequencing (WGS) is currently gold standard COVID-19 surveillance; however, it remains cost-prohibitive requires specialized technical skills. To increase capacity, especially in resource-scarce settings,...
ABSTRACT Background Viral rebound during antiretroviral treatment (ART) is most often driven by suboptimal adherence in the absence of drug resistance. We assessed diagnostic performance point-of-care (POC) tenofovir (TFV) detection urine for prediction viral and resistance ART. Methods performed a nested case-control study within ADVANCE randomized clinical trial (NCT03122262) Johannesburg, South Africa. Adults with human immunodeficiency virus (HIV) newly initiating ART were to receive...
<strong>Background:</strong> The ideal cardiovascular health index (CVHI) is a measure to summarize (CV) health, and includes smoking, body-mass index, physical activity, blood pressure, glucose, total cholesterol, diet. <strong>Objective:</strong> This study aimed assess CV using the CVHI determinants on in rural African population, correlate carotid intima-media thickness (CIMT), surrogate marker for atherosclerosis, with CVHI. <strong>Methods:</strong> A cross-sectional analysis was...
Background . There are limited data on high-risk human papillomavirus (hr-HPV) genotypes among HIV-positive women in Africa, and little is known about their relationship with cervical cytology these populations. Methods We conducted a cross-sectional study 194 (143 from Tanzania, 51 South Africa) to evaluate HPV normal abnormal cytology. Cervical samples were genotyped for types, slides evaluated atypical squamous cell changes according the Bethesda classification system. Results Prevalence...
Objectives HIV infection has been associated with an impaired lung function in high-income countries, but the association between and pulmonary Sub-Saharan Africa remains unclear. This study aims to investigate relation a rural African population. Methods A cross-sectional was conducted among HIV-positive HIV-negative adults area South Africa, as part of Ndlovu Cohort Study. respiratory questionnaire post-bronchodilator spirometry were performed. Multivariable regression analysis used...
Context As life expectancy improves among Human Immunodeficiency Virus (HIV) patients, renal and cardiovascular diseases are increasingly prevalent in this population. Renal disease mutual risk factors characterized by albuminuria. Understanding the interactions between HIV, is first step tackling new therapeutic frontier HIV. Methods In a rural primary health care centre, 903 HIV-infected adult patients were randomly selected data on HIV-infection collected. Glomerular filtration rate...
Abstract Introduction When protease inhibitor (PI)‐based second‐line ART fails, guidelines recommend drug resistance testing and individualized third‐line treatment. However, PI‐resistant viral strains are rare is costly. We investigated whether less costly PI‐exposure can be used to select those patients who would benefit most from testing. Methods performed a retrospective analysis of South African adults living with HIV experiencing failure ritonavir‐boosted‐lopinavir (LPV/r)‐based for...
To document the prevalence of impaired glucose tolerance (IGT) and undiagnosed diabetes mellitus (DM) to identify factors associated with DM in people living HIV (PLWH).Cross-sectional study performed at Ndlovu Medical Center, Limpopo, South Africa including PLWH aged ≥18 years. Between August November 2017, 356 HIV-positive participants were included. Information was collected on socio-demographics, symptoms risk for DM. IGT diagnosed using random plasma and/or HbA1c. Factors assessed by...
<strong>Background:</strong> Antiretroviral therapy (ART) transformed human immunodeficiency virus (HIV) infection into a chronic disease. Possible HIV-associated complications have emerged including cardiovascular diseases (CVD). <strong>Objectives:</strong> This study aims to determine the heart rate variability (HRV) distribution and association between HRV HIV treated with ART in rural African population. <strong>Methods:</strong> cross-sectional included 325 participants of Ndlovu...
In order to limit the expansion of HIV and AIDS epidemic in South Africa, it is important develop targeted prevention strategies. The voluntary counselling testing (VCT) programme appears be effective for preventing spread HI virus. This study adapted guidelines integrated model behaviour prediction (IMBP) into a questionnaire examined extent which predicts behaviour. A sample 92 sports team members from Limpopo ranging 14 30 years age completed questionnaire. Results suggested that beliefs...