A5081834445- Magnesium Alloys: Properties and Applications
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Aluminum Alloys Composites Properties
- Bone Tissue Engineering Materials
- Hydrogen Storage and Materials
- Magnesium in Health and Disease
- HIV/AIDS drug development and treatment
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Orthopedic Surgery and Rehabilitation
- Renal Diseases and Glomerulopathies
- Adipose Tissue and Metabolism
- Parathyroid Disorders and Treatments
- Bone health and osteoporosis research
- Connective tissue disorders research
- Metabolism, Diabetes, and Cancer
- Cardiovascular Issues in Pregnancy
- Corrosion Behavior and Inhibition
- Thallium and Germanium Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Pregnancy and Medication Impact
- Hip disorders and treatments
- Multiple Sclerosis Research Studies
Medical University of Graz
2013-2025
University of Kansas Medical Center
2022-2025
University of Graz
2015
Medical University of Vienna
2014
Antiretroviral therapy (ART) has decreased HIV-1 associated morbidity. However, despite ART, immune cells remain latently infected leading to chronic inflammation and comorbidities. New strategies are needed target viral proteins inflammation. We found activation of Notch3 in renal the mouse model (HIV-Tg26) patients with HIV nephropathy. hypothesized that targeting constitutes an effective for HIV-related kidney diseases (HIV-CKD). generated HIV-Tg26 mice knocked out (Tg-N3KO). Compared at...
Over the last decade, demand has increased for developing new, alternative materials in pediatric trauma care to overcome disadvantages associated with conventional implant materials. Magnesium (Mg)-based alloys seem adequately fulfill vision of a homogeneously resorbable, biocompatible, load-bearing and functionally supportive implant. The aim present study is introduce high-strength, lean alloy Mg‒0.45Zn‒0.45Ca, wt% (ZX00), first time investigate clinical applicability screw osteosynthesis...
Implant removal is unnecessary for biodegradable magnesium (Mg)-based implants and, therefore, the related risk implant-induced fractures limited. Aging, on other hand, associated with low bone-turnover and decreased bone mass density, thus increased fracture risk. Osteoporosis accompanied by Mg deficiency, we hypothesized that Mg-based may support formation Mg2+ ion release in an ovariectomy-induced osteoporotic rat model. Hence, investigated osseointegration implant degradation of a...
Magnesium (Mg)-based implants are promising candidates for orthopedic interventions, because of their biocompatibility, good mechanical features, and ability to degrade completely in the body, eliminating need an additional removal surgery. In present study, we synthesized investigated two Mg-based materials, ultrahigh-purity ZX00 (Mg-Zn-Ca; <0.5 wt% Zn Ca, wt%; Fe-content <1 ppm) Mg (XHP-Mg, >99.999 Mg; ppm), vitro vivo juvenile healthy rats clarify effect alloying elements Ca on...
Obesity and particularly the metabolic syndrome, which is often associated with obesity, combine a major risk for type 2 diabetes cardiovascular disease. Emerging evidence indicate obesity-associated subclinical inflammation primarily originating from adipose tissue as common cause However, suitable well-characterized mouse model to simultaneously study disorders atherosclerosis not available yet. Here we established characterized murine combining diet-induced obesity deteriorations well...
Magnesium (Mg)-based implants are highly attractive for the orthopedic field and may replace titanium (Ti) as support fracture healing. To determine implant-bone interaction in different bony regions, we implanted Mg-based alloy ZX00 (Mg < 0.5 Zn Ca, wt%) Ti-screws into distal epiphysis metaphysis of sheep tibiae. The implant degradation osseointegration were assessed vivo ex after 4, 6 12 weeks, using a combination clinical computed tomography, medium-resolution micro tomography (µCT)...
Ankle is the most common site of hardware removal, mainly performed within 12 months primary surgery. The prominence metallic a frequent cause pain after fracture fixation. Over last decade, development bioresorbable materials based on magnesium (Mg) has increased. Bioresorbable metals aim to avoid second surgery for removal.Twenty patients with isolated, bimalleolar, or trimalleolar ankle fractures were treated screws made Mg, 0.45wt% calcium (Ca) and zinc (Zn) (ZX00). Patient-reported...
Abstract Background In the ongoing development of bioresorbable implants, there has been a particular focus on magnesium (Mg)-based alloys. Several Mg alloys have shown promising properties, including lean, magnesium-zinc-calcium (Mg-Zn-Ca) alloy designated as ZX00. To our knowledge, this is first clinically tested Mg-based free from rare-earth elements or other elements. Its use in medial malleolar fractures allowed for bone healing without requiring surgical removal. It thus interest to...
Magnesium (Mg)-based implants have become an attractive alternative to conventional permanent in the orthopedic field. While biocompatibility, degradation kinetics, and osseointegration of Mg-based been mostly investigated, impact products on bone remodeling potential systemic effects remains unclear. The aim this study was evaluate early mid-term local tissue responses degrading ultrahigh-purity ZX00 (Mg-Zn-Ca alloy) Mg (XHP-Mg) pins a juvenile healthy rat model. differences between implant...
Physical exercise is a well-known modality for maintaining healthy locomotor mechanism. A detailed preclinical research on physical effect bone healing kinetics could help to improve the rehabilitation process after fracture treatment and remodeling. Our aim was evaluate of early post-operative microstructural changes in rat model. Twenty Sprague Dawley male rats underwent bi-cortical 1.6 mm hole drilling both femur diaphysis, which (n = 10) continuous treadmill training (TR) over two weeks,...
Abstract Widespread application of magnesium (Mg) has been prevented by its low strength and poor corrosion resistance. Core this limitation is Mg’s electrochemical potential solubility for most elements, favoring secondary phase precipitation acting as effective micro-galvanic elements. Mg-based metal–metal composites, while benefiting strength, are similarly active galvanic couples. We show that related detrimental susceptibility overcome nanoscale composite architecture design. Nanoscale...
In this study, we introduce a new separation of phases-based activity reporter kinase (SPARK) for AMP-activated (AMPK), named AMPK-SPARK, which reports the AMPK activation by forming bright fluorescent clusters. Furthermore, dual system, GCaMP-AMPK-SPARK, incorporating single-fluorescent protein (FP)-based Ca
Physical exercise has been shown to induce positive reactions in bone healing but next nothing is known about how it affects the nanostructure, particular around implants. In this study, we established link by using small-angle X-ray scattering tensor tomography (SASTT) investigate nanostructural parameters 3D such as mineral particle orientation and thickness. As a model system, rat femoral with bio-resorbable implant (ultra-high purity magnesium) was used. One-half of rats underwent...
The biodegradation behavior of a ternary alloy Mg-4Li-1Ca (LX41) was investigated. Preliminary studies the alloys showed that its property profile may qualify it as material choice for bioresorbable bone implants. However, no data on in vivo were available to date. Here we report results response juvenile growing rats implantation over period 24 weeks based micro-computed tomography and histology examination. A comparison with an established Mg-Zn-Ca revealed higher rate LX41. LX41 implants...
Hintergrund: Hohes Plasma-Fetuin-A ist ein Risikomarker für Typ 2 Diabetes. Wir konnten bereits zeigen, dass Fetuin-A auch bei Frauen mit einer GDM-Anamnese erhöht ist. Hier untersuchen wir die Frage, inwieweit in unserer Studienkohorte Zusammenhang zwischen dem Fetuin-A-Spiegel und körperlicher Fitness besteht.
Die Einteilung der sehr selten vorkommenden Pseudomyxome, auch als Gallertkarzinome bezeichnet, ist abhängig von Zellarchitektur sowie dem Wachstums- und Infiltrationsverhalten. Nach Bradlley et al. (WHO) werden Low-grade-Pseudomyxome (G1) High-grade-Pseudomyxomen (G2-G4) unterschieden. Ronnett teilt sie in disseminierte peritoneale Adenomuzinosen (DPAM) peritoneal muzinöse Karzinomatosen (PMCA) ein. Mit einer Inzidenz 1 – 2 Neuerkrankungen pro 1.000.000 Einwohner Jahr ohne...
Introduction Physical exercise is a well-known modality for maintaining healthy locomotor mechanism. A detailed preclinical research on physical effect bone healing kinetics could help to improve the rehabilitation process after fracture treatment and remodeling. Therefore, we evaluated of early post-operative microstructural changes in rat model.
Antiretroviral therapy (ART) has decreased HIV-1 associated morbidity. However, despite ART, immune cells remain latently infected and slowly release viral proteins, leading to chronic inflammation comorbidities. New strategies are needed target proteins inflammation. We found activation of Notch3 in several renal the mouse model (HIV-Tg26) patients with HIV Nephropathy. hypothesized that targeting constitutes an effective for HIV-related kidney diseases (HIV-CKD). generated HIV-Tg26 mice...