A5004619147- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Nanoparticle-Based Drug Delivery
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Ear and Head Tumors
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Lung Cancer Diagnosis and Treatment
- Inhalation and Respiratory Drug Delivery
- Peptidase Inhibition and Analysis
- Infrared Thermography in Medicine
- Effects of Radiation Exposure
- Cancer-related molecular mechanisms research
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Research Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Vascular Anomalies and Treatments
- Cancer Mechanisms and Therapy
- Angiogenesis and VEGF in Cancer
- Galectins and Cancer Biology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Radiotherapy Techniques
- Breast Cancer Treatment Studies
- RNA Interference and Gene Delivery
TCM-Intigrated Cancer Center of Southern Medical University
2018-2025
Southern Medical University
2022
Central South University
2014-2017
Third Xiangya Hospital
2014-2017
Hunan University of Traditional Chinese Medicine
2016
Sun Yat-sen University
2012-2014
The First Affiliated Hospital, Sun Yat-sen University
2012-2014
Zero to Three
2012
Guangzhou Medical University
2006
Inhalation of chemotherapeutic drugs directly into the lungs augments drug exposure to lung cancers. The inhalation free however results in over and causes severe adverse effect normal cells. In present study, epidermal growth factor (EGF)-modified gelatin nanoparticles (EGNP) was developed administer doxorubicin (DOX) EGNP released DOX a sustained manner effectively internalized EGFR overexpressing A549 H226 cancer cells via receptor-mediated endocytosis. vitro cytotoxicity assay showed...
This study was undertaken to analyze the correlation between primary gross tumor volume (GTVp) and prognosis in patients with nasopharyngeal carcinoma (NPC) undergoing intensity-modulated radiation therapy (IMRT).Between February 2001 December 2006, 305 NPC treated IMRT were analyzed retrospectively. GTVp calculated from treatment planning CT scans.Univariate multivariate analyses indicated that had a statistically significant local control, distant metastasis, overall survival NPC, whereas...
This study aims to investigate the feasibility of contouring target volume according residual tumor and decreasing dose regression field after induction chemotherapy (IC) in locoregionally advanced nasopharyngeal carcinoma (NPC).From August 2009 2013, patients with stage III-IVB NPC were treated IC concurrent chemoradiotherapy. Gross nasopharynx (GTVnx)-residual gross cervical lymph node (GTVnd)-residual contoured post-IC primary any N+ disease, respectively. The was included CTVnx1/CTVnd1...
Purpose The purpose of this study was to determine the efficacy and safety low-dose radiotherapy (LDR) for postoperative local chest wall recurrence breast cancer. Methods records 52 patients with recurrent cancer treated at our center from January 2019 December 2022. t-test used compare means LDR group non group. Categorical data were compared using chi-square test. Kaplan-Meier method factors associated survival. Results Compared who did not undergo LDR, in showed a higher incidence grade...
Abstract Background The purpose of this study was to investigate the incidence retropharyngeal lymph node (RPLN) metastasis and explore associated risk factors using CT MRI, direct clinical radiotherapy in hypopharyngeal carcinoma (HPC). Methods MRI images 218 patients with pathologically confirmed HPC were analyzed retrospectively. chi‐square test logistic regression used for statistical analysis. Results RPLN 17.0%, highest rate 36.4% found pharyngeal wall carcinoma. None N0 classification...
The correlation between primary tumor volume and nasopharyngeal carcinoma (NPC) UICC 2002 T classification, N classification distant metastasis after radiation therapy was discussed to provide further evidence for the inclusion of into TNM staging system.Between February 2001 December 2008, 666 patients with NPC treated intensity-modulated (IMRT) were analyzed retrospectively. Primary gross calculated from treatment planning computed tomography scans. Kruskal-Wallis Mann-Whitney tests used...
There is limited understanding of tracheal carcinoma (TC) because its rarity. We examined the efficacy radiotherapy (RT) for patients with primary TC.We analyzed records 32 TC who received RT at our center between November 1996 and December 2016.Thirteen adjuvant 18 definitive RT. Eight achieved complete remission (CR) after Among all patients, 5-year overall survival (OS) rate was 46.9% locoregional progression free (LRPFS) 68.1%. Univariate analysis indicated OS better in those adenoid...
Objective: To explore the clinical efficacy of HiPorfin photodynamic therapy for advanced esophageal cancer and evaluate its impact on survival. Methods: Retrospective analysis 32 patients with obstructive at our institution from September 2013 to December 2016. was infused as photosensitizer a dose 5 mg/kg, after 48 hours, 630-nm laser irradiation subsequently performed through an optical fiber that passed biopsy channel flexible endoscope. Results: The effectiveness rate 78.1% (25/32),...
This study aimed to investigate the clinical significance of cullin 3 expression in nasopharyngeal carcinoma (NPC), as well explore regulatory mechanism underlying growth and metastasis NPC cells. Our findings showed that levels were significantly increased both tissues cell lines. A strong positive correlation was found between Ki-67-based proliferation index tissues. Moreover, overexpression correlated with local relapse distant patients. In vitro experiments knockdown caused a significant...
Our study suggested that the major risk factors for postoperative bleeding after nasal endoscopic surgery (NES) included hypertension, long-term non-steroidal anti-inflammatory drugs (NSAIDs), and previous surgery. The use of preoperative corticosteroids is a valuable measure reducing NES.To explore NES find effective measures to reduce or prevent condition.A total 641 patients who underwent were analyzed retrospectively. Univariate analysis logistic regression performed potential...
Inhalation of chemotherapeutic drugs directly into the lungs augments drug exposure to lung cancers. The inhalation free however results in over and causes severe adverse effect normal cells. In present study, epidermal growth factor (EGF)-modified gelatin nanoparticles (EGNP) was developed administer doxorubicin (DOX) EGNP released DOX a sustained manner effectively internalized EGFR overexpressing A549 H226 cancer cells via receptor-mediated endocytosis. vitro cytotoxicity assay showed...
To identify the locoregional extension of hypopharyngeal carcinoma (HPC), particularly invasion nasopharynx and skull base, metastasis level VI retropharyngeal lymph node (RPLN) by investigating computed tomography (CT) magnetic resonance (MR) images; together with radiotherapy target HPC.CT MR images 186 patients pathologically confirmed HPC between Aug 2000 Dec 2010 were analyzed retrospectively. We used χ(2) test logistic regression to analyze local regional spread determine their...
Background: Lymphopenia at diagnosis is considered a negative prognostic factor for patients with extra-nodal natural killer (NK)/T-cell lymphoma (ENKTL), especially that of the absolute cluster differentiation 4+ T cell count (ACD4C), which has previously been identified as an independent in other hematologic malignancies. However, there limited data available regarding value peripheral blood lymphocyte subsets ENKTL patients. The purpose this study was to investigate subsets, ACD4C...
Dihydromyricetin (Figure 1) is the main flavonoid compound in ampelopsis großedentata and exists many natural plants. To date, only rare methods pharmacokinetic studies of dihydromyricetin have been reported [1]. study pharmacokinetics dihydromyricetin, beagle dogs were treated by orally at different doses RP-HPLC-UV method used to determine plasma. The parameters are calculated Pharmacokinetic Module DAS2.1 software. confirmed that temperature key factor affects stability plasma built a...
Abstract Background: More than 40% of nasopharyngeal carcinoma (NPC) come from China, and the incidence rate in South China is extremely high. Poorly differential squamous (PDNSC) most common pathological type, while detailed molecular mechanisms remain unclear. Objectives: This study aimed to explore role MYL9 carcinogenesis, progression chemoresistance PDNSC, as well specific biological pathogenesis paclitaxel resistance, provide a new theoretical basis targeted drugs for PDNSC. Methods:...