A5029713349- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Retinopathy of Prematurity Studies
- Congenital Diaphragmatic Hernia Studies
- Neonatal Health and Biochemistry
- Birth, Development, and Health
- Infant Nutrition and Health
- Fatty Acid Research and Health
- Preterm Birth and Chorioamnionitis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Diabetes and associated disorders
- Infant Development and Preterm Care
University of Gothenburg
2018-2024
Institute of Clinical Research
2020
<h3>Importance</h3> Lack of arachidonic acid (AA) and docosahexaenoic (DHA) after extremely preterm birth may contribute to morbidity, including retinopathy prematurity (ROP). <h3>Objective</h3> To determine whether enteral supplementation with fatty acids from 40 weeks’ postmenstrual age reduces ROP in infants. <h3>Design, Setting, Participants</h3> The Mega Donna trial, a randomized clinical was multicenter study performed at 3 university hospitals Sweden December 15, 2016, 2019. screening...
Studies indicate that reduced foetal haemoglobin levels are related to increased neonatal morbidity rates. This study investigated the relationships between sampling-related blood loss and adult transfusions administered during postnatal days 1-14 development of severe morbidities in extremely preterm infants born before 28 weeks gestation.The medical files 149 at two university hospitals Sweden from 2013 2018 were investigated.Blood sampling resulted a 58% depletion endogenous volume...
BACKGROUNDHyperglycemia, insulin insensitivity, and low IGF1 levels in extremely preterm infants are associated with an increased risk of retinopathy prematurity (ROP), but the interactions incompletely understood.METHODSIn 117 infants, serum glucose parenteral intake were recoded daily first postnatal week. Serum measured weekly. Mice oxygen-induced alone versus plus streptozotocin-induced hyperglycemia/hypoinsulinemia assessed for glucose, insulin, IGF1, IGFBP1, IGFBP3 blood liver....
Blood loss and adult blood transfusions are common during the neonatal period in preterm infants. The objective of study was to clarify if degree fetal haemoglobin (HbF) associated with later retinopathy prematurity (ROP).Retrospective observational cohort study. In total, 452 infants born <30 gestational weeks at a tertiary level intensive care unit Sweden 2009-2015 were included, 385 whom had final ROP outcome. Mean fractions HbF (%) first postnatal week calculated from 11 861 arterial gas...
Objective Early decrease in fetal haemoglobin (HbF) is an indicator of loss endogenous blood components that might have predictive value for development bronchopulmonary dysplasia (BPD). The link between HbF and BPD has not been evaluated. Design Retrospective observational study. Setting Tertiary level neonatal intensive care unit, referral centre Southern Sweden. Patients 452 very preterm infants (<30 gestational weeks) born 2009–2015. Interventions Regular clinical practice. Main...
Fetal and early postnatal inflammation have been associated with increased morbidity in extremely preterm infants. This study aimed to demonstrate if postpartum levels of docosahexaenoic acid (DHA) arachidonic (AA) were inflammation. In a cohort 90 infants, DHA AA cord blood, on the first day 7 examined relation systemic inflammation, defined as elevated C-reactive protein (CRP) and/or interleukin-6 (IL-6) within 72 h from birth, or without positive blood culture. Median serum level was 0.5...
<h3>Importance</h3> Circulating levels of neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) are important in the course brain injury adults, but longitudinal postnatal circulating preterm infants have not been investigated. <h3>Objectives</h3> To examine serum NfL GFAP during first 15 weeks life to explore possible associations between these biomarkers, neonatal morbidities, neurodevelopmental outcomes at 2 years. <h3>Design, Setting, Participants</h3> This cohort study...
Abstract Background Growth factors important for normal brain development are low in preterm infants. This study investigated the link between growth and volumes at term. Material/methods Infants born <28 weeks gestational age (GA) were included. Endogenous levels of insulin-like factor (IGF)−1, brain-derived factor, vascular endothelial platelet-derived (expressed as area under curve [AUC] serum samples from postnatal days 1, 7, 14, 28) utilized a multivariable linear regression model....
Abstract Background Cytokines and growth factors (GF) have been implicated in the development of retinopathy prematurity (ROP) bronchopulmonary dysplasia (BPD). We hypothesize that even small coordinated changes inflammatory proteins or GFs may reveal underlying regulating mechanisms do not induce obvious concentration individual proteins. therefore applied correlation network analysis serum to determine early characteristics these conditions. Methods Concentrations 17 cytokines five were...
Objective To investigate the relationship between fraction of fetal haemoglobin (HbF(%)) and oxygen requirement as determined by inspired (FiO 2 ) alveolar–arterial gradient (A–a gradient). Increased alveolar exposure to may explain association decreased HbF(%) development bronchopulmonary dysplasia (BPD). Design Longitudinal, retrospective, observational study. Setting Tertiary-level neonatal intensive care unit, referral centre for southern Sweden. Patients Four hundred forty very preterm...
Following preterm birth, serum levels of insulin-like growth factor 1 (IGF-1) decrease compared to corresponding in utero levels. A recent clinical trial indicated that supplementation with recombinant human (rh) IGF-1/rhIGF-binding protein 3 (rhIGF-1/rhIGFBP-3) prevents severe intraventricular hemorrhage (IVH) extremely infants. In a rabbit pup model, we characterized endogenous and hepatic IGF-1, along brain distribution IGF-1 receptor (IGF1R). We then evaluated the effects...
Little is known about the individual response of glucose-regulating factors to administration exogenous insulin infusion in extremely preterm infants.To evaluate longitudinal serum concentrations insulin, C-peptide, and plasma glucose levels a high-frequency sampling regimen infants treated with because hyperglycemia.Prospective cohort study.Two university hospitals Sweden between December 2015 September 2016.Serum samples were obtained from nine infants, gestational age 22 (+3) 26 (+5)...
AimsTo investigate the amount of blood loss and transfusions in extremely preterm infant during first two weeks life, with current clinical sampling transfusion practices.Further on, to any association between early development morbidities infants.