A5010186264- Growth Hormone and Insulin-like Growth Factors
- Neonatal Respiratory Health Research
- Retinopathy of Prematurity Studies
- Fatty Acid Research and Health
- Osteoarthritis Treatment and Mechanisms
- Photosynthetic Processes and Mechanisms
- Infant Nutrition and Health
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Photoreceptor and optogenetics research
- Lipid metabolism and biosynthesis
- Neonatal Health and Biochemistry
- Orthopedic Surgery and Rehabilitation
- Thyroid Disorders and Treatments
- Bone fractures and treatments
- Algal biology and biofuel production
- Mitochondrial Function and Pathology
- Plant Molecular Biology Research
- Mesenchymal stem cell research
- TGF-β signaling in diseases
- Knee injuries and reconstruction techniques
- Digestive system and related health
- Plant Stress Responses and Tolerance
- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
University of Gothenburg
2016-2025
Sahlgrenska University Hospital
1998-2024
Neuroscience Institute
2022-2024
Baxter (Sweden)
2022-2023
Karolinska Institutet
2019
Stockholm University
2019
University of Belgrade
2019
New England Baptist Hospital
2000
Brigham and Women's Hospital
2000
Lund University
1997-1999
Autologous cultured chondrocyte transplantation was introduced in Sweden 1987 for the treatment of large (1.5-12.0 cm2) full thickness chondral defects knee. The clinical, arthroscopic, and histologic results from first 101 patients treated using this technique are reported study. Patients were assessed retrospectively three types endpoints: patient physician derived clinical rating scales (five validated two new); arthroscopic assessment cartilage fill, integration, surface hardness;...
Adult New Zealand rabbits were used to transplant autologously harvested and in vitro cultured chondrocytes into patellar chondral lesions that had been made previously 3 mm diameter, extending down the calcified zone. Healing of defects was assessed by gross examination, light microscope, histological-histochemical scoring at 8, 12, 52 weeks. Chondrocyte transplantation significantly increased amount newly formed repair tissue compared found control knees which lesion solely covered a...
The jasmonate family of phytohormones plays central roles in plant development and stress acclimation. However, the architecture their signaling circuits remains largely unknown. Here we describe a binding protein, cyclophilin 20-3 (CYP20-3), which regulates stress-responsive cellular redox homeostasis. (+)-12-oxo-phytodienoic acid (OPDA) promotes CYP20-3 to form complex with serine acetyltransferase 1, triggers formation hetero-oligomeric cysteine synthase O -acetylserine(thiol)lyase B...
<h3>Importance</h3> Lack of arachidonic acid (AA) and docosahexaenoic (DHA) after extremely preterm birth may contribute to morbidity, including retinopathy prematurity (ROP). <h3>Objective</h3> To determine whether enteral supplementation with fatty acids from 40 weeks’ postmenstrual age reduces ROP in infants. <h3>Design, Setting, Participants</h3> The Mega Donna trial, a randomized clinical was multicenter study performed at 3 university hospitals Sweden December 15, 2016, 2019. screening...
Whether growth hormone stimulates longitudinal bone by a direct effect at the site of plate or indirectly increasing concentration circulating somatomedins (insulin-like factors) has been subject controversy. Immunohistochemical methods were used to explore localization and distribution insulin-like factor I (IGF-I) immunoreactivity in epiphyseal proximal tibia male rats. Cells proliferative zone normal rats exhibited bright immunofluorescence, whereas cells germinal hypertrophic zones...
The mechanism of action for the stimulatory effect GH on longitudinal bone growth is not yet clarified. Several recent reports indicate that has a direct at site epiphyseal plate, as opposed to somatomedin hypothesis which holds mediated by circulating insulin-like factors (IGFs). Using RNA probe in solution hybridization assay we investigated presence IGF-I mRNA rat rib plate. Hypophysectomy resulted decrease number copies compared normal rats. Replacement treatment with restored...
A glycerol-nonutilizing mutant of the salt-tolerant yeast Debaryomyces hansenii was isolated. When subjected to salt stress produced glycerol, and internal level glycerol increased linearly in proportion increases external salinity as wild-type strain. However, at showed a more pronounced decrease growth rate yield lost surrounding medium than did wild type. Uptake experiments be accumulated against strong concentration gradient, both strains displayed similar kinetic parameters for uptake...
ABSTRACT Levels of mRNA for the insulin-like growth factor-I (IGF-I) in rat heart and skeletal muscle its dependence on GH were investigated using a solution hybridization assay. IGF-I decreased following hypophysectomy, replacement therapy with human (hGH) normalized levels. The stimulatory effect hGH was dose-dependent, lowest effective dose being 100 μg. A significant increase observed 60 min after s.c. administration μg maximum apparent 6–12 h injection. Administration 200 or 11 insulin...
Abstract In natural habitats, plants frequently experience rapid changes in the intensity of sunlight. To cope with these and maximize growth, adjust photosynthetic light utilization electron transport photoprotective mechanisms. This involves a proton motive force (PMF) across thylakoid membrane, postulated to be affected by unknown anion (Cl − ) channels. Here we report that bestrophin-like protein from Arabidopsis thaliana functions as voltage-dependent Cl channel electrophysiological...
Background & aimsThe purpose of the study was to compare effects parenteral emulsion SMOFlipid®, with 15% fish oil, Clinoleic® on retinopathy prematurity (ROP) and other morbidities growth, their impact longitudinal serum levels fatty acids. Retinopathy prematurity, morbidity growth were correlated each lipid supplement.MethodsNinety infants born at gestational age <28 weeks randomized treatment SMOFlipid® or Clinoleic®. Two thirds (66%) received nutrition for up 14 days birth (median 8,...
Summary Plants are highly capable of recognizing and defending themselves against invading microbes. Adapted plant pathogens secrete effector molecules to suppress the host's immune system. These may be recognized by host‐encoded resistance proteins, which then trigger defense in form hypersensitive response ( HR ) leading programmed cell death host tissue at infection site. The three proteins PEN 1, 2 3 have been found act as central components wall‐based non‐adapted powdery mildew Blumeria...
To study the effect of locally infused growth hormone (GH) or insulin-like factor I(IGF-I) on slowly cycling cells in germinal cell layer tibial plate, osmotic minipumps delivering 14.3 microCi [3H]thymidine per day were implanted s.c. into hypophysectomized rats, and GH (1 microgram) IGF-I (10 micrograms) was injected daily through a cannula proximal tibia. The opposite leg served as control. After 12 days treatment, removed, three rats each group given (20 micrograms/day, s.c.) for an...
The effect of local administration growth hormone (GH) and insulinlike factor 1 (IGF-1) on longitudinal bone was studied in the proximal tibia hypophysectomized rats, by using tetracycline method. Human GH (hGH) stimulated when administered into epiphysial plate, epiphysis through an implanted cannula, or knee joint intraarticularly. In contrast, hGH metaphysis did not cause such a stimulation. dose dependent, lowest daily that caused stimulation 50 ng. produced cloned bacteria as effective...
Mice with oxygen-induced retinopathy fed matched diets except for ω-3 long-chain polyunsaturated fatty acids (LC-PUFAs) vs ω-6 LC-PUFAs demonstrate relative antiangiogenic and neuroprotective associations of LC-PUFAs. However, supplementing preterm infants has been inconsistent in reducing major morbidities. few studies measured serum lipid levels after supplementation.To examine the associated risk prematurity (ROP) from circulating LC-PUFAs.This longitudinal clinical study was a further...
<h3>Importance</h3> Supplementing preterm infants with long-chain polyunsaturated fatty acids (LC-PUFA) has been inconsistent in reducing the severity and incidence of retinopathy prematurity (ROP). Furthermore, few studies have measured long-term serum lipid levels after supplementation. <h3>Objective</h3> To assess whether ROP is associated LC-PUFA, especially docosahexaenoic acid (DHA) arachidonic (AA), during first 28 postnatal days. <h3>Design, Setting, Participants</h3> This cohort...
Abstract Two photosystems, I and II, absorb convert light energy in photosynthesis chloroplasts of green plants. The genes psbA psaAB the cytoplasmic chloroplast genome encode core components photosystem II I, respectively. Here we show that absolute amounts respond, a complementary manner, to changes quality preferentially excite each mustard seedlings. We also initial response altered distribution is change rates transcription psaAB. Changes chlorophyll fluorescence emission vivo suggest...
The most abundant chlorophyll-binding complex in plants is the intrinsic membrane protein light-harvesting II (LHC II). LHC acts as a antenna and has an important role distribution of absorbed energy between two photosystems photosynthesis. We used spectroscopic techniques to study synthetic peptide with identical sequence IIb N terminus found pea, without phosphorylated Thr at 5th amino acid residue, both forms native full-length protein. Our results show that changes structure upon...
ABSTRACT Expression of insulin-like growth factor I (IGF-I) mRNA and its dependence on GH was studied in rat epiphyseal plate by in-situ hybridization. Methodological aspects the technique were first evaluated fixed sagittal cryosections from 28-day-old plates to ascertain specific In-situ hybridization compared sections 10- rats GH-dependence 35-day-old hypophysectomized rats. IGF-I apparent chondrocytes proliferative, hypertrophic early degenerative zones The 10-day-old showed a weak...
The effect of human GH (hGH) on colony formation rat epiphyseal plate chondrocytes was studied in suspension culture. Chondrocytes were isolated enzymatically from plates the proximal tibia 28-day-old normal male rats, and cultured a stabilized with 0.5% agarose. After approximately 7 days culture presence 10% newborn calf serum (NCS), chondrocyte colonies developed consisting varying numbers cells matrix. No absence NCS, number formed proportional to concentration NCS (5–20%) medium. hGH...
ABSTRACT The effect of human GH (hGH) and insulin-like growth factor-I (IGF-I) on colony formation rabbit epiphyseal tibial chondrocytes at different stages maturation was studied in suspension culture. plate from the proximal tibia 8-week-old male rabbits dissected divided into three (proximal, intermediate distal) zones, each zone representing an enrichment germinative, proliferative hypertrophic cell layers respectively. Chondrocytes these zones were isolated by collagenase digestion...