A5055105900- Metabolomics and Mass Spectrometry Studies
- Plant Taxonomy and Phylogenetics
- Advanced Fluorescence Microscopy Techniques
- Digital Holography and Microscopy
- Mass Spectrometry Techniques and Applications
- Optical Coherence Tomography Applications
- Near-Field Optical Microscopy
- Bamboo properties and applications
- Analytical Chemistry and Chromatography
- Metabolism and Genetic Disorders
- Orbital Angular Momentum in Optics
- Nerve injury and regeneration
- Image Processing Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Nanoplatforms for cancer theranostics
- Plant Gene Expression Analysis
- Advanced Battery Materials and Technologies
- Plant responses to water stress
- Spinal Cord Injury Research
- Per- and polyfluoroalkyl substances research
- Microfluidic and Bio-sensing Technologies
- Advancements in Battery Materials
- Pluripotent Stem Cells Research
- Plant biochemistry and biosynthesis
- Mitochondrial Function and Pathology
Xi'an Institute of Optics and Precision Mechanics
2020-2025
Chinese Academy of Sciences
2016-2025
University of Chinese Academy of Sciences
2016-2025
Chinese Academy of Forestry
2025
Guangdong Academy of Forestry
2025
Ocean University of China
2025
Beijing National Laboratory for Molecular Sciences
2019-2024
Kunming University of Science and Technology
2024
First People's Hospital of Yunnan Province
2024
Shaoyang University
2024
Ferroptosis, an iron-dependent regulated cell death process driven by excessive lipid peroxides, can enhance cancer vulnerability to chemotherapy, targeted therapy and immunotherapy. As essential upstream for ferroptosis activation, peroxidation of biological membranes is expected be primarily induced intrabilayer reactive oxygen species (ROS), indicating a promising strategy initiate improving the local content diffusion-limited ROS in bilayer. Herein, liposomes embedded with PEG-coated 3...
Research has demonstrated that many myelin-associated inhibitory molecules jointly contribute to the failure of adult spinal cord regeneration. Therapies comprehensively targeting multiple nature injured are being concerned. Here, two collagen-binding proteins, CBD-EphA4LBD and CBD-PlexinB1LBD, were constructed, respectively, neutralize axon guidance ephrinB3 sema4D inhibit regeneration nerve fibers. The neutralizing proteins have proven their ability specifically bind collagen continuously...
Enabled by multiple optical traps, holographic tweezers can manipulate particles in parallel flexibly. Spatial light modulators are widely used tweezers, which Gaussian point (GP) trap arrays or special mode including vortex (OV) arrays, perfect (PV) and Airy beam etc., be generated addressing various phase holograms. However, the traps these almost all of same type. Here, we propose a new method for generating hybrid array (HOTA), where such as GPs, OVs, PVs, beams focal plane combined...
Abstract Malignant proliferation and metastasis are the hallmarks of cancer cells. Aminated [70]fullerene exhibits notable antineoplastic effects, promoting it a candidate for multi‐targeted drugs. It is an urgent need to reveal structure–activity relationship aminated fullerenes. Herein, three amphiphilic derivatives [60]fullerene with clarified molecular structures synthesized: TAPC‐4, TAPC‐3, TCPC‐4. TAPC‐4 inhibits diverse tumor cells via G0/G1 cell cycle arrest, reverses...
Cisplatin, the alkylating agent of platinum(II) (Pt(II)), is most common antitumor drug in clinic; however, it has many side effects, therefore higly desired to develop low toxicity platinum(IV) (Pt(IV)) drugs. Multi-omics analysis, as a powerful tool, been frequently employed for mechanism study certain therapy at molecular level, which might be helpful elucidating platinum drugs and facilitating their clinical application.
ABSTRACT Light‐sheet fluorescence microscopy (LSFM) provides an ideal tool for long‐term observation of live specimens due to its low photodamage and fast volumetric imaging speed. The wavefront distortions in the illumination path LSFM will reduce intensity broaden light‐sheet thickness, thereby degrading image quality. We propose use shaping technique scattering effect shrink thickness. Scanning refocused laser beam generate LS improves both axial resolution. resolution can be further...
Sasarubrovaginata is transferred to Yushania based on morphological and molecular evidence. The lectotype for S.rubrovaginata designated. Besides, a revised description of this species key the four distributed in Cenwanlaoshan Mountain are also provided.
Platygyra daedalea Ellis & Solander, 1786, is a dominant species within the world's warmest reefs, making it critical model for investigating coral stress resistance and adaptive evolutionary mechanisms. This study presents first sequenced annotated mitogenome of reef-building P. daedalea. The 16,363 bp in length, containing 13 protein-coding genes, two ribosomal RNA transfer genes. base composition 24.8% adenine (A), 13% cytosine (C), 20.4% guanine (G), 41.8% thymine (T), with G-C content...
The matrix plays a prominent role in expanding the ability of assisted laser desorption/ionization mass spectrometry (MALDI MS). However, on account unclarity necessary properties MALDI MS, development new is still exploratory stage and lacks systematic theoretical guidance. Meanwhile, most existing matrices are unable to simultaneously detect various high-molecular-weight (high-MW) lipids including (poly-)phosphoinositides, cardiolipins, gangliosides. In this study, we have successfully...
An automatic approach to identification of natural products (NPid) in complex extracts by exploring pure shift HSQC (psHSQC) and H2BC spectra the mixture is developed, which integrated information on chemical shifts (CS), adjacent relationships (AR) peak intensities (PI) 1H–13C groups for candidate product a customized NMR database. A weighted comprehensive score calculated each from values CS, AR PI rate likelihood its existence mixture. Using crude extract crabapple (Malus fusca) as an...
We demonstrated a compact optical module that is capable of efficiently generating vector vortex beams (VVB). With this device, linearly polarized input beam can be converted into with arbitrary spatial polarization and phase distributions, accompanied by an energy utilization up to 61%. Equally important, the area light modulator, key component in as high 65.5%. designed vector-vortex-beam-generation module, several types VVBs different topological charges distributions were created...
Abstract Background: Gastric cancer (GC) is one of the malignant tumors, with complex molecular mechanisms. Ferroptosis plays an important regulatory role in development GC. But no studies have investigated specific mechanism ferroptosis natural killer (NK) cells This study aims to elucidate GC regulating NK cells. Methods: qRT-qPCR was used test expression circular RNA decaprenyl diphosphate synthase subunit 1 (circPDSS1) and microRNA-1278 (miR-1278). The protein expressions glutathione...
Abstract Octa(aminophenyl) polyhedral oligomeric silsesquioxane (OAP‐POSS) and boron‐containing phenol‐formaldehyde resin (BPFR) were synthesized, respectively. The BPFR nanocomposites with different OAP‐POSS content (wt%) prepared, their properties characterized. results show that the thermal degradation process of this can be divided into three stages, they are all following first order mechanism. residual ratio activation energy E a 9 wt% OAP‐POSS/BPFR both better than others increase...
Light-sheet fluorescence microscopy (LSFM) facilitates high temporal-spatial resolution, low photobleaching and phototoxicity for long-term volumetric imaging. However, when a axial resolution or optical sectioning capability is required, the field of view (FOV) limited. Here, we propose to generate large FOV light-sheet by scanning multiple focus-shifted Gaussian beam arrays (MGBA) while keeping resolution. The positions waists are shifted in both lateral directions an optimized arranged...
Molecular farming utilizes plants as a platform for producing recombinant biopharmaceuticals. Duckweed, the smallest and fastest growing aquatic plant, is promising candidate molecular farming. However, efficiency of current transformation methods generally not high in duckweed. Here, we developed fast efficient procedure Lemna minor ZH0403, requiring 7–8 weeks from screening calluses to transgenic with stable 88% at DNA level 86% protein level. We then used this system produce chicken...
NAD(P)H:quinone oxidoreductase 1 (NQO1) is overexpressed in a broad range of human tumors but remains difficult to study. Herein, we report novel two-photon fluorescent probe with NIR emission for NQO1 detection. The demonstrated superior analytical performance large Stokes shift and deep tissue penetration.
Multiple myeloma is a type of malignancy, which affects the plasma cells bone marrow. Recent studies have found that malignant may express urokinase plasminogen activator (uPA) and uPA receptor (uPAR), initiation proteolytic events by this system contributes to process invasion destruction Studies also suggested level soluble form uPAR (suPAR) act as marker for prognosis in patients with multiple myeloma, there an association between uPAR/suPAR expression, clinical characteristics, efficacy...
Embryonic stem cells (ESCs), which are characterized by the capacity for self-renewal and pluripotency, hold great promise regenerative medicine. Increasing evidence points to essential role of mitophagy in pluripotency regulation. Our recent work showed that PINK1/OPTN take part guarding ESC mitochondrial homeostasis pluripotency. Evaluating ESCs is important exploring relationships between smaller size than adult somatic mitophagosomes difficult observe. Many methods have been employed-for...