A5064336852- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Phosphodiesterase function and regulation
- RNA modifications and cancer
- Cancer-related gene regulation
- RNA Research and Splicing
- Connective tissue disorders research
- Wnt/β-catenin signaling in development and cancer
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Nuclear Structure and Function
Scripps Research Institute
2023-2025
Children’s Institute
2020-2021
University of California, San Diego
2020-2021
cAMP response element-binding protein (CREB)-regulated transcription coactivator 1 (CRTC1) plays an important role in synaptic plasticity, learning, and long-term memory formation through the regulation of neuronal activity-dependent gene expression, CRTC1 dysregulation is implicated Alzheimer’s disease (AD). Here, we show that increased S-nitrosylation (forming SNO-CRTC1), as seen cell-based, animal-based, human-induced pluripotent stem cell (hiPSC)-derived cerebrocortical neuron-based AD...
Abstract DNA methyltransferases (DNMTs) catalyze methylation at the C5 position of cytosine with S -adenosyl- l -methionine. Methylation regulates gene expression, serving a variety physiological and pathophysiological roles. The chemical mechanisms regulating DNMT enzymatic activity, however, are not fully elucidated. Here, we show that protein S-nitrosylation cysteine residue in DNMT3B attenuates activity consequent aberrant upregulation expression. These genes include Cyclin D2 ( Ccnd2 ),...
Structural birth defects occur in approximately 3% of live births; most such lack defined genetic or environmental causes. Despite advances surgical approaches, pharmacologic prevention remains largely out reach.
SUMMARY CREB-regulated transcription coactivator 1 (CRTC1) plays an important role in synaptic plasticity, learning and long-term memory formation through regulation of neuronal activity-dependent gene expression, CRTC1 dysregulation is implicated Alzheimer’s disease (AD). Here, we show that increased S-nitrosylation (forming SNO-CRTC1), as seen cell-based, animal-based, human induced pluripotent stem cell (hiPSC)-derived cerebrocortical neuron-based AD models, disrupts its binding with CREB...