A5088330785- Motor Control and Adaptation
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Behavioral and Psychological Studies
- Sport Psychology and Performance
- Muscle activation and electromyography studies
- Children's Physical and Motor Development
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- EEG and Brain-Computer Interfaces
- Sports Performance and Training
- Action Observation and Synchronization
- Stroke Rehabilitation and Recovery
- Botulinum Toxin and Related Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Takotsubo Cardiomyopathy and Associated Phenomena
- Neurogenesis and neuroplasticity mechanisms
- Visual and Cognitive Learning Processes
- Pharmacological Effects and Toxicity Studies
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Therapeutic Uses of Natural Elements
- Poisoning and overdose treatments
Juntendo University
2014-2025
Weatherford College
2024
Juntendo University Hospital
2021
National Institute of Advanced Industrial Science and Technology
2021
Tokai University
2021
Taiho Pharmaceutical (Japan)
2015-2018
Nagoya University
1978-2017
Kagoshima University
2014
Douglas Mental Health University Institute
2012
McGill University
2012
Early clinical trials conducted primarily in Japan have shown that TAS-102, an oral agent combines trifluridine and tipiracil hydrochloride, was effective the treatment of refractory colorectal cancer. We a phase 3 trial to further assess efficacy safety TAS-102 global population such patients.In this double-blind study, we randomly assigned 800 patients, 2:1 ratio, receive or placebo. The primary end point overall survival.The median survival improved from 5.3 months with placebo 7.1 hazard...
This is the first clinical trial of this type in Japan, designed to analyze two important aspects Alzheimer's disease (AD) management using medium-chain triglycerides. Axona was administered for 3 months (40 g powder containing 20 caprylic triglycerides). We used an indurating, four-step dose-titration method (from 10 40 per day) 7 days before trial, and examined tolerance adverse effects intervention. also investigated its effect on cognitive function mild-to-moderate AD patients.This a...
Multiple system atrophy (MSA) is classified into two main types: parkinsonian and cerebellar ataxia with oligodendrogliopathy. We examined microstructural alterations in the white matter substantia nigra pars compacta (SNc) of patients MSA type (MSA-P) using multishell diffusion magnetic resonance imaging (dMRI) myelin sensitive techniques. Age- sex-matched MSA-P (n = 21, n 10 first second cohorts, respectively), Parkinson's disease 19, 17), healthy controls 20, 24) were enrolled....
Abstract Background Psychosis is known as one of the non-motor symptoms Parkinson’ s disease (PD). typically associated with an increased burden regarding living activities in PD and thus constitutes a serious public health problem. Aims & Objectives We hypothesized that visual hallucinations would be predicted by neurodegeneration specific regions. consecutively enrolled 228 patients between October 2016 March 2021 at Juntendo University Hospital Japan. Method All were assessed for...
Abstract Background Approximately 10 - 20 % pregnant women have been diagnosed with depression, and 3 6% receive SSRI treatment. In Japan, it reported that approximately 1% of (105 out 10,000 births) were prescribed SSRIs during the perinatal period. Importantly, crossed placenta may affect outcomes in infants exposed to these drugs pregnancy human. Several large cohort studies conducted, some finding significant differences risk ASD others not. present study, we created an animal model a...
Electroconvulsive therapy (ECT) is known as a successful treatment for severe depression. Despite great efforts, the biological mechanisms underlying beneficial effects of ECT remain largely unclear. In this study, animals received single, 10, or 20 applications electroconvulsive seizure (ECS), and then cell proliferation apoptosis were investigated in subgranular zone (SGZ) dentate gyrus. We analyzed whether series ECSs could induce changes gyrus dose-response fashion. A single-ECS...
Monoamine oxidase type B inhibitors, including selegiline, are established as anti-Parkinsonian Drugs. Inhibition of monoamine enzymes might suppress the inflammation because inhibition to generate reactive oxygen species. However, its effect on brain microstructure remains unclear. The aim this study is elucidate white matter and substantia nigra (SN) microstructural differences between Patients with Parkinson's disease without selegiline treatment by two independently recruited cohorts.
Levodopa-induced dyskinesia is a complication of levodopa therapy and negatively impacts the quality life patients. We aimed to elucidate white matter alterations in Parkinson's disease with levodopa-induced using advanced diffusion magnetic resonance imaging techniques.The enrolled subjects included 26 clinically confirmed patients without dyskinesia, 25 23 healthy controls. Subjects were imaged 3-T scanner. Diffusion tensor imaging, kurtosis neurite orientation dispersion density findings...
Objective: It has been reported that neonatal bone abnormalities occur as a result of long-term intravenous magnesium administration (MgSO4) to pregnant women. The purpose this retrospective study was evaluate the frequency such and clinical background both mothers neonates. PatientsandMethods: We reviewed maternal (114 cases) (139 charts from all women who received MgSO4 for preterm labor preeclampsia between June 1 1992, May 31,1994. All chest X-ray films were obtained within 48 h after...
Impulse control behaviors (ICBs) in Parkinson's disease (PD) are thought to be caused by an overdose of dopaminergic therapy the relatively spared ventral striatum, or hypersensitivity this region dopamine. Alterations brain networks now also contribute development ICBs.To comprehensively assess white matter microstructures PD patients with ICBs using advanced diffusion MRI and magnetization transfer saturation (MT-sat) imaging.This study included 19 (PD-ICBs), 18 without (PD-nICBs), 20...
Controllability of motor imagery is one the critical factors for effectiveness mental practice. It generally defined as ability to control or manipulate menta1ly. In this study, a new test measure controllability (CMI test) was developed and its validity reliability were examined. The CMI constructed from 15 different tasks with following five controls per task. University students required image basic movement pose then successively according instruction. After successive control, subjects...
<i>Objective:</i> As animal models have suggested enhancement of xenobiotic-induced hepatotoxicity due to restraint stress, a case-control study was undertaken investigate the effects physical on development drug-induced liver injury (DILI) in psychiatric intensive care unit. <i>Method:</i> Demographic and clinical characteristics were compared between restrained patients (n = 106) nonrestrained 528) admitted unit during 4-year period from January 2003 December 2006....
Patients with bipolar disorder often report self-perceived treatment resistance. However, it is not known to what extent due actual The Juntendo University provides “Bipolar Disorder Treatment Rebuilding Program,” in which patients self-reported resistant are hospitalized for 2 weeks and undergo detailed examinations. In this study, we our experience the initial 43 during one half years after launch of program. Among who underwent full assessment, only was regarded as having genuine...
Pyruvate dehydrogenase complex (PDHC) deficiency, a major cause of congenital lactic acidemia in children, usually is complicated by seizures, and, some patients, West syndrome has occurred. We diagnosed 60 patients with PDHC including equal numbers affected males and females. studied the clinical features 10 caused examined relation to mutation E1α subunit, representing great majority deficiencies. Among 30 boys girls 1 boy 9 had syndrome, even though overall shows slight male...
The long-term efficacy of deep brain stimulation (DBS) for motor fluctuations in advanced Parkinson's disease (PD) has been well established; however, may recur over time despite multiple adjustments DBS settings and medications.We conducted a retrospective chart review three patients whom levodopa-carbidopa intestinal gel (LCIG) was additionally administered as rescue therapy secondary failure due to the recurrence fluctuations.The had PD with duration 14-19 years, undergone refractory...
Aim Change in catecholamine seems to be associated with not only effects of electroconvulsive therapy ( ECT ), but also adverse events . Our aim this study was investigate whether or influences the concentration over long term. Patients a major depressive episode schizophrenia, diagnosed according DSM‐IV criteria, who were newly admitted J untendo U niversity H ospital receive , recruited. Methods Urine collected during 24 h before first treatment, after final treatment and 1 week treatment....