A5100398648- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Retinal Development and Disorders
- MicroRNA in disease regulation
- Ocular Oncology and Treatments
- Inflammasome and immune disorders
- Ocular Diseases and Behçet’s Syndrome
- Advanced Glycation End Products research
- Cancer-related Molecular Pathways
- Vascular Tumors and Angiosarcomas
- Ophthalmology and Visual Impairment Studies
- Retinoids in leukemia and cellular processes
- Retinal and Macular Surgery
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Urban Heat Island Mitigation
- Heme Oxygenase-1 and Carbon Monoxide
- Intraocular Surgery and Lenses
- Cerebral Venous Sinus Thrombosis
- Diabetes Management and Education
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
Yunnan University
2025
Fudan University
2021-2022
Eye & ENT Hospital of Fudan University
2015-2022
Air Force Medical University
2022
National Health and Family Planning Commission
2022
Southern Medical University
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Hainan Medical University
2019-2020
Union Hospital
2019
Jilin University
2019
Purpose: To examine the thickness of macular choroid and its associations in school children aged 6 to 18 years. Methods: The school-based cross-sectional Shandong Children Eye Study included 6026 (94.7%) 6364 eligible fulfilling inclusion criterion an age from 4 Spectral-domain optical coherence tomography (SD-OCT) was performed for a subgroup 972 6+ All participants underwent ocular examinations, including measurement visual acuity, cycloplegic refractometry, biometry, SD-OCT (enhanced...
Introduction Diabetes mellitus (DM) and diabetic retinopathy (DR) increase the global burden. Since their pathogenesis is complex, it necessary to use biopsychosocial model discover most effective strategies. The study aimed investigate psycho-behavioral factors of DR confirm discrepancies from previous studies. Research design methods comprised seven cycles cross-sectional data National Health Nutrition Examination Survey (NHANES) 2005–2006 2017–2018. Samples DM were selected this complex...
Abstract Purpose To explore the subfoveal thickness of sclera ( SST ), choroid SCT ) and retina SRT as well their relationship in healthy Chinese children with varying levels refractive error. Methods A total 810 schoolchildren adolescents underwent a series comprehensive ocular examinations, swept‐source optical coherence tomography (OCT) after induced cycloplegia. The thicknesses sclera, below central fovea were measured manually, each measurement was compared across different statuses....
Significance Oxidative stress-induced damage to retinal pigmented epithelial (RPE) cells is critically implicated in the pathogenesis of age-related macular degeneration (AMD), a leading cause blindness elderly. Here we report that oxidative heterochromatin formation essential promote RPE survival. Mechanistically, damage-induced occurs at 53 target promoters apoptosis genes and regulated by p53 sumoylation. Our study demonstrates mechanistic links among chromatin conformation, sumoylation,...
As climate challenges intensify, architectural design must reconcile energy efficiency with environmental adaptation. This study investigates how two skywell geometries in Kunming’s traditional One-Seal dwellings (Yikeyin) optimize seasonal thermal and ventilation performance. Combining field analysis simulations, a comparative of depth-to-width ratios reveals that larger proportions enhance summer airflow but exacerbate winter heat loss, while smaller stabilize conditions. Vertical...
The major ophthalmic complication in patients with diabetes is diabetic retinopathy (DR), which one of the eye diseases that causes blindness. It well established occurrence and duration DR positively correlated diabetes. Advanced glycation end product (AGE) accumulation factor leads to development DR. However, underlying mechanisms remain unclear. In present study, role phosphoinositide 3‑kinase/protein kinase B (Akt) signaling AGE‑induced was investigated. An vitro experimental system used...
To describe the multimodal imaging and treatment of a 37-year-old male presenting with bilateral ischemic retinopathy induced by methamphetamine abuse.A presented progressively deteriorating vision was found to have branch retinal artery occlusion central vein in both eyes along secondary vitreous hemorrhage left eye following seven years intermittent intranasal abuse. Fundus fluorescein angiography optical coherence tomography revealed large areas non-perfusion peripheral retina...
To investigate protective effects of a novel recombinant decoy receptor drug RC28-E on retinal damage in early diabetic rats.The streptozotocin (STZ)-induced rats were randomly divided into 6 groups: diabetes mellitus (DM) group (saline, 3 µL/eye); at low (0.33 µg/µL, µL), medium (1 and high (3 µL) dose groups; vascular endothelial growth factor (VEGF) Trap µL); fibroblast (FGF) µL). Normal control was included. At week 1 4 following induction, the intravitreally injected with corresponding...
As the global trend of diabetes intensifies, burden vision-threatening retinopathy, particularly diabetic retinopathy (DR), is increasing. There an urgent need to seek strategies for early prevention and control DR. This study attempted comprehensively evaluate relationship between dietary nutrient intake risk DR provide assistance doctors in guiding diet patients. Data from eligible participants with US National Health Nutrition Examination Survey (NHANES) 2003-2018 were analyzed....
Purpose. To compare the functional and anatomical outcomes of one dose three loading doses followed by pro re nata (PRN) regimen in Chinese neovascular age-related macular degeneration (nvAMD) (including polypoidal choroidal vasculopathy (PCV)) patients. Methods. In this multicenter, prospective, open-label, controlled, 12-month study (ClinicalTrials.gov: NCT02810808), patients were randomized (1 : 1) to 1 + PRN (PRN group) or 3 (LD using intravitreal ranibizumab treatment. Best-corrected...
To evaluate the effects of intensive control blood glucose and pressure on microvascular complications in patients with type II diabetes by comparing therapeutic standard treatment diabetes.A total 107 were randomly assigned into groups. Patients group received preterax (perindopril/ indapamide) to pressure, gliclazide (diamicron) MR glucose. routine medications or placebo. Urinary microalbumin (UMA), urinary creatinine (UCR), UMA/UCR ratio, visual acuity monitored according study design...
Purpose To seek novel diagnostic approaches, we improved the workflow of cell-free DNA (cfDNA) sequencing and evaluated its feasibility in vitreoretinal lymphoma (VRL) specimens; profile mutations was preliminarily analyzed for potential value. Methods The study a trial. 23 eyes patients with VRL 25 inflammatory eye diseases were enrolled. Approximate 500μl undiluted vitreous humor 10ml diluted fluid obtained through vitrectomy sent cytopathological examinations. spared cfDNA sequencing. For...
The present study aimed to investigate the level of translocator protein (TSPO) and its correlation with different inflammatory cytokines in diabetic retinopathy (DR) patients. Peripheral blood samples were obtained from 54 DR patients 22 age-related cataract (ARC) mRNA expression TSPO, voltage-dependent anion channel (VDAC), apoptosis-associated speck like a caspase recruitment domain (ASC), NOD-like receptors pyrin domain-containing 3 (NLRP3) caspase-1 examined by reverse...
Objectives To evaluate the foveal avascular zone (FAZ) area in healthy volunteers using optical coherence tomography angiography (OCTA) and identify factors that influence FAZ. Methods This single-center cross-sectional study included 526 eyes of 263 who underwent macular scanning by Zeiss OCTA. A linear mixed model was used to investigate effects systemic (age, sex, blood pressure, height, weight) ocular (intraocular biometric parameters, central thickness) on Results In total, 520 262 were...
Abnormal expression of microRNAs (miRNAs/miRs) has been previously reported in various types human cancer, such as retinoblastoma (RB). Dysregulated miRNAs have demonstrated to be important epigenetic regulators numerous biological events associated with RB. Therefore, improved understanding the precise roles RB is required develop novel therapeutic strategies for treatment patients this disease. In present study, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was...
To find the significant altered proteins in age-related macular degeneration (AMD) patients as potential biomarkers of AMD.A comparative analysis protein pattern AMD versus healthy controls was performed by means proteomic using two-dimensional gel electrophoresis followed identification with MALDI TOF/TOF mass spectrometry.We identified 28 that were significantly clinical relevance patients. These involved a wide range biological functions including immune responses, growth cytokines, cell...
Purpose: To investigate the characteristics of retinal periarterial capillary-free zone (paCFZ) with wide-field swept-source optical coherence tomography angiography (SS-OCTA) in eyes branch vein occlusion (BRVO). Methods: Seventy treatment-naïve BRVO and 35 healthy were included. The paCFZ areas, artery calibers, areas major arteries unaffected quadrants measured 12 × 12-mm SS-OCTA images compared those contralateral eyes. Other multimodal imaging data collected. Results: There no...
This retrospective study investigated the clinical characteristics of multiple subretinal fluid blebs (MSFBs) after successful surgery for rhegmatogenous retinal detachment (RRD) and explored association between MSFB with best-corrected visual acuity (BCVA) metamorphopsia.The comprised 206 patients RRD, 58 148 eyes undergoing, respectively, scleral buckling (SB), pars plana vitrectomy (PPV). The MSFBs were analyzed by optical coherence tomography (OCT). choroidal vessels in some cases...
Objective To observe the change of treatment and to analyze its clinical characteristics a multiple evanescent white dot syndrome.Methods A case suspected syndrome was followed up in outpatient,best corrected visual acuity,fundus examination by preset lens,fundus photography,optical coherence tomography (OCT),fluorescein fundus angiography (FFA)/ indocyanine green (ICGA),visual field ERG were performed on first visit 25th day,respectively.Prednisone 40mg administrated.Results The acuity...