A5013381424- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Global Cancer Incidence and Screening
- Lipid metabolism and disorders
- Colorectal Cancer Screening and Detection
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 and Mental Health
- Ethics in Clinical Research
- Drug-Induced Hepatotoxicity and Protection
- Cancer Genomics and Diagnostics
- Digital Radiography and Breast Imaging
- Single-cell and spatial transcriptomics
- Protease and Inhibitor Mechanisms
- Renal cell carcinoma treatment
- Insect Resistance and Genetics
- Hepatitis Viruses Studies and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Diet and metabolism studies
- Viral-associated cancers and disorders
- Diverticular Disease and Complications
- AI in cancer detection
Imperial College London
2020-2024
The Francis Crick Institute
2024
University of Oxford
2024
West Middlesex University Hospital
2020-2022
University of Cambridge
2018-2021
Cambridge School
2019-2021
Faculty (United Kingdom)
2021
West Suffolk NHS Foundation Trust
2021
The COVID-19 pandemic has brought unprecedented challenges to the medical workforce. This put them at increased risk of burnout a time when levels are already worryingly high in profession, with recent studies consistently showing that around half doctors meet validated criteria for burnout. Objectives To understand wider factors influencing and impacting upon hospital doctors’ well-being during England. Design Cross-sectional survey mixed quantitative–qualitative analysis. Setting Acute...
Alpha-1 antitrypsin deficiency (A1ATD) is a life-threatening condition caused by the inheritance of serpin family A member 1 "Z" genetic variant driving alpha-1 (AAT) protein misfolding in hepatocytes. There are no approved medicines for this disease.
ABSTRACT Background & Aims A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated with hepatic fat and advanced histology in non-alcoholic fatty liver disease (NAFLD), however, these findings have not consistently replicated the literature. We aimed to establish whether rs641738C>T is a risk factor across spectrum of NAFLD characterize its role regulation related metabolic phenotypes through meta-analysis. Methods performed meta-analysis studies data on...
Summary Animal models of human disease are a key component translational research and yet there is often no consensus on which model optimal for particular disease. Here, we generated database 3,920 rodent non-alcoholic fatty liver (NAFLD). Study designs were highly heterogeneous therefore few had been cited more than once. Analysis genetic provided evidence the role adipose dysfunction perturbation innate immune system in progression NAFLD. We identified that high-fat, high-fructose diets...
Im, Yu Ri BSc; Dong, Jiawen BA; Paterson, Anna Louise MB BChir, PhD FRCPath; Harper, Simon MD, FRCS (RCS Eng); Peters, James MRCP, MPhil, Author Information
Abstract The classical drug development pipeline necessitates studies using animal models of human disease to gauge future efficacy in humans, however, there is a comparatively low conversion rate from success animals humans. Non-alcoholic fatty liver (NAFLD) complex chronic without any licensed therapies and hence major field research. We performed meta-analysis 414 interventional rodent (6,575 animals) NAFLD assess the mean difference hepatic triglyceride content. 20 21 studied classes had...
Abstract Aim Intimate examinations are potentially uncomfortable and embarrassing. In addition to offering chaperones routinely, it is also important clearly document the circumstances, with implications on patient dignity safeguarding both patients staff. We aimed analyse quality of chaperone documentation in breast clinic before after intervention. Method Audit standards (GMC Chelsea & Westminster Trust guidelines): [1] Consent [2] Chaperone use/refusal, [3] role identity should be...