A5045705154- Cerebrospinal fluid and hydrocephalus
- Advanced biosensing and bioanalysis techniques
- Spinal Dysraphism and Malformations
- Traumatic Brain Injury and Neurovascular Disturbances
- Emergency and Acute Care Studies
- MicroRNA in disease regulation
- Head and Neck Surgical Oncology
- Extracellular vesicles in disease
- Electrospun Nanofibers in Biomedical Applications
- Medical Education and Admissions
- Interpreting and Communication in Healthcare
- Ultrasound in Clinical Applications
- Analytical Chemistry and Sensors
- Cancer Genomics and Diagnostics
- Neonatal and fetal brain pathology
- Innovations in Medical Education
- Respiratory Support and Mechanisms
- Electrochemical sensors and biosensors
- Pancreatic and Hepatic Oncology Research
- Diversity and Career in Medicine
- RNA Interference and Gene Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Tracheal and airway disorders
- Stoma care and complications
- Advanced Sensor and Energy Harvesting Materials
Children's Hospital of Los Angeles
2022-2024
University of Southern California
2023
University of California, San Francisco
2023
City of Hope
2019
University of California, Riverside
2017-2018
University of California System
2018
Riverside
2018
Abstract Extracellular vesicles (EVs) actively participate in intercellular communication and pathological processes. Studying the molecular signatures of EVs is key to reveal their biological functions clinical values, which, however, greatly hindered by sub‐100 nm dimensions, low quantities biomolecules each EV carries, large population heterogeneity. Now, single‐EV flow cytometry analysis introduced realize single counting phenotyping a conventional cytometer for first time, enabled...
BACKGROUND Family-centered rounds (FCR) is the standard of care in inpatient pediatrics. Results studies have revealed that Spanish-speaking families can experience communication challenges and decreased empowerment on rounds. In our study, we aim to identify variation FCR practices for compared English-speaking factors contributing these disparities. METHODS This a cross-sectional observational study performed by secondary analysis quality improvement initiative conducted at quaternary...
The objective of this study was to describe trends in the utilization infection prevention techniques (standard care, intrathecal [IT] antibiotics, antibiotic-impregnated catheters [AICs], and combination IT antibiotics AICs) among participating hospitals over time.
National guidelines recommend against continuous pulse oximetry use for hospitalized children with bronchiolitis who are not receiving supplemental oxygen, yet guideline-discordant remains high.To evaluate deimplementation outcomes of educational outreach and audit feedback strategies aiming to reduce in oxygen.A nonrandomized clinical single-group trial was conducted 14 non-intensive care units 5 freestanding children's hospitals 1 community hospital from December 1, 2019, through March 14,...
Encapsulation of ionic nanoparticles in a hydrogel microparticle, i.e. microgel, produces target-stimulated probe for molecular detection. Selective reactive oxygen species (ROS) release the enclosed cations from microgel which subsequently turn on fluorogenic dyes to emit intense fluorescence, permitting rapid detection ROS or ROS-producing molecules. The ROS-responsive provides advantages simple fabrication, bright and stable signals, easy handling, response, carrying great promise...
Abstract Background Cerebrospinal fluid (CSF) shunts allow children with hydrocephalus to survive and avoid brain injury (J Neurosurg 107:345-57, 2007; Childs Nerv Syst 12:192-9, 1996). The Hydrocephalus Clinical Research Network implemented non-randomized quality improvement protocols that were shown decrease infection rates compared pre-operative prophylactic intravenous antibiotics alone (standard care): initially intrathecal (IT) between 2007–2009 Pediatr 8:22-9, 2011), followed by...
Abstract Background Infection prevention techniques used during cerebrospinal fluid (CSF) shunt surgery include: (1) standard perioperative intravenous antibiotics, (2) intrathecal (IT) (3) antibiotic-impregnated catheter (AIC) tubing, or (4) Both IT and AIC. These have not been assessed against one another for their impact on the infecting organisms patterns of antimicrobial resistance. Methods We performed a retrospective longitudinal observational cohort study children with initial CSF...
Abstract Extracellular vesicles (EVs) actively participate in intercellular communication and pathological processes. Studying the molecular signatures of EVs is key to reveal their biological functions clinical values, which, however, greatly hindered by sub‐100 nm dimensions, low quantities biomolecules each EV carries, large population heterogeneity. Now, single‐EV flow cytometry analysis introduced realize single counting phenotyping a conventional cytometer for first time, enabled...
<h3>Introduction</h3> Surgical treatment is the only definitive to halt progression of neuromuscular scoliosis (NMS) but associated with complication rates 17–40%. Caregivers experience considerable uncertainty during decision-making. This study aims identify topics for which a concern caregivers and how interpret that uncertainty. <h3>Methods</h3> From two quaternary children's hospitals, we recruited English- Spanish-speaking adult children aged 8–21 years NMS who had previously decided...
We compare cytokine profiles at the time of initial CSF shunt placement between children who required no subsequent revision surgeries and requiring repeated for failure. also describe across surgical episodes undergo multiple surgeries.