A5061844192- Viral Infections and Vectors
- Vector-borne infectious diseases
- Bacterial Infections and Vaccines
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Pneumonia and Respiratory Infections
- Yersinia bacterium, plague, ectoparasites research
- Complement system in diseases
- Zoonotic diseases and public health
- Fire effects on ecosystems
- Transboundary Water Resource Management
- Insect symbiosis and bacterial influences
- Viral Infections and Outbreaks Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Pediatric health and respiratory diseases
- Water resources management and optimization
- Blood groups and transfusion
- Malaria Research and Control
- Remote Sensing in Agriculture
- Influenza Virus Research Studies
- Genetic Associations and Epidemiology
- Microbial infections and disease research
- Water-Energy-Food Nexus Studies
- Radiopharmaceutical Chemistry and Applications
- Infective Endocarditis Diagnosis and Management
Central Research Institute of Epidemiology
2015-2024
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2015-2021
FKUZ Stavropol Rospotrebnadzor Anti Institute
2020
Skolkovo Institute of Science and Technology
2019
Interstate Commission for Water Coordination of Central Asia
2003-2017
International Water Management Institute
2008-2017
Yale University
2014
New York Medical College
2014
University of California, Irvine
2014
Nantucket Cottage Hospital
2014
Borrelia miyamotoi is distantly related to B. burgdorferi and transmitted by the same hard-body tick species. We report 46 cases of infection in humans compare frequency clinical manifestations this with those caused garinii infection. All patients lived Russia had influenza-like illness fever as high 39.5°C; relapsing febrile occurred 5 (11%) erythema migrans 4 (9%). In Russia, rate Ixodes persulcatus ticks was 1%-16%, similar rates I. ricinus western Europe scapularis United States. may...
From July 25 to October 1, 1999, 826 patients were admitted Volgograd Region, Russia, hospitals with acute aseptic meningoencephalitis, meningitis, or fever consistent arboviral infection. Of 84 cases of 40 fatal. Fourteen brain specimens positive in reverse transcriptase-polymerase chain reaction assays, confirming the presence West Nile/Kunjin virus.
During the last decade Crimean-Congo hemorrhagic fever (CCHF) emerged and/or re-emerged in several Balkan countries, Turkey, southwestern regions of Russian Federation, and Ukraine, with considerable high fatality rates. Reasons for re-emergence CCHF include climate anthropogenic factors such as changes land use, agricultural practices or hunting activities, movement livestock that may influence host-tick-virus dynamics. In order to be able design prevention control measures targeted at...
Abstract Borrelia miyamotoi sensu lato, a relapsing fever sp., is transmitted by the same ticks that transmit B. burgdorferi (the Lyme disease pathogen) and occurs in all disease–endemic areas of United States. To determine seroprevalence IgG against lato northeastern States assess whether serum from lato–infected persons reactive to antigens, we tested archived samples area residents during 1991–2012. Of 639 healthy persons, 25 were positive for 60 burgdorferi. Samples ≈10%...
The genetic variability at six polymorphic loci was examined within a global collection of 502 isolates subgroup III, serogroup A Neisseria meningitidis. Nine "genoclouds" were identified, consisting genotypes that isolated repeatedly plus 48 descendent rarely. These genoclouds have caused three pandemic waves disease since the mid-1960s, most recent which imported from East Asia to Europe and Africa in mid-1990s. Many are escape variants, resulting positive selection we attribute herd...
Abstract Borrelia miyamotoi is a relapsing fever spirochete in Ixodes ticks that has been recently identified as human pathogen causing hard tick-borne (HTBRF) across the Northern Hemisphere. No validated serologic test exists, and current assays have low sensitivity early HTBRF. To examine humoral immune response against B. miyamotoi, we infected C3H/HeN mice with strain LB-2001 expressing variable small protein 1 (Vsp1) demonstrated spirochetemia was cleared after 3 d, coinciding anti-Vsp1...
Phagocytosis of bacteria constitutes an important defense mechanism against invasive bacterial diseases. Efficacy phagocytosis by polymorphonuclear neutrophils is known to vary between allotypes FcγRIIa (a class Fc receptors for immunoglobulins that constitutively expressed on neutrophils). We compared the distribution FcγRIIa-R131 and FcγRIIa-H131 in 98 Slavic complement-sufficient patients with meningococcal disease 107 healthy controls. A strong association was found IIa-R/R131 allotype...
Substantial exposure to Borrelia miyamotoi occurs through bites from Ixodes ricinus ticks in the Netherlands, which also transmit burgdorferi sensu lato and Anaplasma phagocytophilum. Direct evidence for B. infection European populations is scarce. A flu-like illness with high fever, resembling human granulocytic anaplasmosis, has been attributed infections relatively small groups. associated chronic meningoencephalitis have described case reports. Assuming that an IgG antibody response...
From July to September 1999, a widespread outbreak of meningoencephalitis associated with West Nile virus (Flavivirus, Flaviviridae) occurred in southern Russia, hundreds cases and dozens deaths. Two strains isolated from patient serum brain-tissue samples reacted hemagglutination-inhibition neutralization tests patients' convalescent-phase sera immune ascites fluid other virus.
The purpose of this study was to examine the occurrence late complement component deficiency (LCCD) states in USSR. Thirty deficient individuals were detected: 27 with C8 beta and 3 C7 deficiency. Among a first episode meningococcal infection, about 1% had LCCD, whereas among patients recurrent bacterial meningitis prevalence LCCD rose approximately 50%. This corresponds for 12 per 100,000 general population. identified experienced 77 episodes disease acute meningitis. Mathematical analysis...
Potential West Nile virus (family Flaviviridae, genus Flavivirus, WNV) vectors were assessed during 2003 at indoor and outdoor collection sites in urban Volgograd, Russia, three nearby towns surrounding rural areas. In total, 9,182 female mosquitoes comprising 13 species six genera collected. Relative abundance bloodmeal host utilization differed temporarily spatially. During June July Aedes vexans (Meigen) (85.4%) Culex p. pipiens L. (7.6%) the two most abundant collected indoors, whereas...
Background: Intravenous ribavirin has been reported to be an effective treatment for haemorrhagic fever with renal syndrome (HFRS) caused by Hantaan virus in Asia. However, its therapeutic benefits HFRS Puumala (PUUV) Europe are still unknown.Methods: A randomized, open-label study of efficacy and safety intravenous the was conducted European part Russia. Seventy-three patients suspected within 4 d onset disease were randomized receive either (33 mg/kg, followed 16 mg/kg given every 6 h 8 3...