A5076204522- Viral Infections and Vectors
- Yersinia bacterium, plague, ectoparasites research
- Respiratory viral infections research
- Vector-borne infectious diseases
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Pediatric health and respiratory diseases
- Viral Infections and Outbreaks Research
- Liver Disease Diagnosis and Treatment
- Zoonotic diseases and public health
- Human Health and Disease
- Healthcare Systems and Public Health
- Clinical Nutrition and Gastroenterology
- COVID-19 Clinical Research Studies
- Vitamin C and Antioxidants Research
- Diet, Metabolism, and Disease
- Bacillus and Francisella bacterial research
- Hepatitis C virus research
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Vibrio bacteria research studies
- Viral Infections and Immunology Research
- Bacterial Infections and Vaccines
- Alcoholism and Thiamine Deficiency
- Poisoning and overdose treatments
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2015-2024
Central Research Institute of Epidemiology
2015-2024
Stavropol State Medical University
2016
Children's City Clinical Hospital №11
2011
Yale University
2011
Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences
1995
Ministry of Health of the Russian Federation
1994
Borrelia miyamotoi is distantly related to B. burgdorferi and transmitted by the same hard-body tick species. We report 46 cases of infection in humans compare frequency clinical manifestations this with those caused garinii infection. All patients lived Russia had influenza-like illness fever as high 39.5°C; relapsing febrile occurred 5 (11%) erythema migrans 4 (9%). In Russia, rate Ixodes persulcatus ticks was 1%-16%, similar rates I. ricinus western Europe scapularis United States. may...
Whereas the XX century marked history of acute respiratory disease investigation as a period for generating in-depth system combating influenza viruses (Articulavirales: Orthomyxoviridae, Alpha-/Betainfluenzavirus) (based on environmental and virological monitoring A virus in its natural reservoir — aquatic semi-aquatic birds to supervising epidemic influenza), similar is necessary build up XXI with regard especially dangerous betacoronaviruses (Nidovirales: Coronaviridae, Betacoronavirus):...
During a 2-year period in 2005-2007, we conducted surveillance of group A rotaviruses and other enteric agents among patients hospitalized with acute gastroenteritis 8 different cities the Russian Federation. Fecal specimens were gathered from 3208 children (including 2848 aged <5 years) 1354 adults who admitted to hospitals Moscow, St. Petersburg, Chelyabinsk, Nizhnii Novgorod, Tyumen, Khabarovsk, Makhachkala, Yakutsk. Polymerase chain reaction was performed detect groups C, noroviruses...
In spite of vaccination was recommended by the World Health Organization, main strategy influenza is antiviral drugs treatment, one which umifenovir. Aim. The aim study to obtain additional data on safety and therapeutic efficacy drug Arbidol (umifenovir) in patients with a diagnosis common cold. Materials methods. Double-blind, randomized, placebo-controlled clinical investigating Treatment Prophylaxis Influenza Common Cold (ARBITR) IV phase started November 2011 completed April 2016 basis...
Antiviral drugs are critical adjuncts to influenza vaccination. This study determined the in vitro susceptibilities of A and B viruses isolated 2010-2011 season Russia neuraminidase inhibitor oseltamivir hemagglutinin fusion umifenovir clinical efficacy this antiviral season.The potency these against A(H1N1)pdm09 virus mice was assessed. Importantly, effectiveness evaluated a retrospective conducted 26 regions Russia.All tested (n=36) were susceptible vitro. Oseltamivir (10mg/kg/day) (60...
To evaluate the efficacy and safety of Arbidol (umifenovir) in adult patients with influenza.The analysis preliminary results multicenter double-blind randomized placebo-controlled post-marketing study ARBITR was performed. A total 293 adults aged 18 to 65 years influenza or acute respiratory tract infection no more than 36 hours' duration were enrolled study. Individuals into 2 treatment groups: oral umifenovir 200 mg four times daily for 5 days placebo days. The endpoints time resolution...
In 2016, in the territory of Yamalo-Nenets Autonomous District an outbreak anthrax took place, 2650 reindeers were infected. As a consequence contacts with affected and fallen animals, 36 cases human infection occurred, which one was fatal. Performed full-extent complex anti-epidemic, anti-epizootic, preventive measures, prompt organization operations at regional level allowed for localization large-scale focus within minimum possible time. Based on lessons learned, identified ways to...
Antiviral drugs can play a significant role in the control of influenza. Umifenovir (Arbidol) is licensed and widely used Russia for prophylaxis and/or treatment We evaluated susceptibility to umifenovir reference influenza A B viruses isolated from patients ARBITR clinical trial 2012‐2014 seasons. Using an MDCK cell‐based enzyme‐linked immunosorbent assay (ELISA), we showed that replication antigenically dominant human was efficiently inhibited by umifenovir. The wild‐type А/Perth/265/2009...
Введение. Для COVID-19 характерна мультиморбидность с поражением не только органов дыхания, но и сердечно-сосудистой, мочевыделительной нервной систем желудочно-кишечного тракта. Клинические симптомы заболевания объединены в гастроинтестинальный синдром, регистрируемый 30-79% случаев. При этом начало болезни может сопровождаться диареей у 50% пациентов как сочетаться катаральными явлениями со стороны носоглотки, так предшествовать им. Цель работы. Оценить особенности микробиоты кишечника...
To clarify the clinical, laboratory, and epidemiological characteristics of relapsing Ixodes tick-borne borreliosis (ITB) caused by Borrelia miyamotoi.Retrospective clinical observation was made in 79 inpatients Republican Infectious Diseases Hospital (Udmurt Republic), who had been diagnosed with B. miyamotoi-caused disease verified real-time polymerase chain reaction. The latter enzyme immunoassay ruled out possible vector-borne coinfections (ITB burgdorferi sensu lato; encephalitis;...
To identify risk factors (RFs) for the development of bacterial complications and prolonged course influenza other acute respiratory viral infections (ARVIs) among inpatients treated in Russian healthcare facilities post-pandemic period; to determine clinical presentation disease (flu-like syndrome) risk-group people evaluate efficacy antiviral therapy with arbidol (umifenovir).The investigators retrospectively analyzed randomly selected medical records ARVI 88 hospitals from 50 regions...
Ixodes tick-borne borreliosis caused by Borrelia miyamotoi (ITBB-BM) is a previously unknown infectious disease discovered in Russia. Aim. The present study continues the investigation of clinical features ITBB-BM context an immune system-pathogen interaction. Subjects and methods. enrolled 117 patients with comparison group 71 Lyme (LD) that ITBB erythema migrans. All were treated at New Hospital, Yekateringburg. More than 100 clinical, epidemiological laboratory parameters obtained from...
The inhibitory effects of carrageenans (CRGs) on lipopolysaccharide (LPS) induced inflammation in a mouse model endotoxemia and complex therapy patients with enteric infections Salmonella etiology were studied. atomic force microscopy (AFM) examination LPS its mixture CRGs showed that the morphology is significantly changed under action κ- κ/β-CRGs. able to increase synthesis anti-inflammatory interleukin 10 (IL-10) vitro, and, at low concentrations, their activity was higher. protective...
At present, a major challenge in research that addresses risks of hospital-acquired infections (HAIs) is the lack methodological and theoretical studies generalizing available knowledge sphere whereas applied works are plentiful. In recent years, methods influence on epidemic process HAIs have been reassessed some experts believe transition to risk-based approach be quite promising this respect. This makes it possible take timely measures aimed at reducing such advance. Since within...
Presented are summarized data on anthrax epidemiological and epizootiological situation in the Russian Federation. The causes of unstable analyzed. Characterized modern clinical features infection, as well key areas for improvement surveillance control current conditions based a systematic approach effective interdepartmental cooperation.
Filoviruses are important etiological agents of emergent diseases with high mortality rates. Traditionally, filovirus fever have primarily been a burden African countries; however, global interconnectedness has increased the probability worldwide spread filoviruses. Therefore, national healthcare organizations need tools for managing risk, including diagnostic kits based on real-time reverse transcription PCR (RT-qPCR), as this is most suitable method diagnosing diseases. Here we describe...
Ixodes tick-borne borrelioses (ITBB) are caused by two different spirochetes: Borrelia from the group of burgdorferi sensu lato, agents classic Lyme borreliosis (LB), and miyamotoi that belongs to causing relapsing fevers. ITBB B. (BM-ITBB) is a previously unknown infectious disease discovered in Russia. It known LB sequelae may reduce long-term life guality convalescents.To study follow-up those who have recovered new BM-ITBB infection comparison with persons had LB.The investigation...