A5072025316- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Renal and related cancers
- Circular RNAs in diseases
- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- COVID-19 Clinical Research Studies
- RNA Research and Splicing
- Genomics, phytochemicals, and oxidative stress
- Urinary and Genital Oncology Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Immunotherapy and Biomarkers
- HVDC Systems and Fault Protection
- Sirtuins and Resveratrol in Medicine
- Phagocytosis and Immune Regulation
- Nuts composition and effects
- Liver Disease and Transplantation
Nantong University
2013-2025
Affiliated Hospital of Nantong University
2013-2025
Nanjing Medical University
2017-2021
Jiangsu Province Hospital
2017-2021
ORCID
2021
Northeast Agricultural University
2010
Acute kidney injury (AKI) induced by ischemia‐reperfusion is a critical conundrum in many clinical settings. Here, this study aimed to determine whether and how RTA‐408, novel oleanane triterpenoid, could confer protection against renal (IRI) male mice. Mice treated with RTA‐408 undergoing unilateral ischemia followed contralateral nephrectomy had improved function histological outcome, as well decreased apoptosis, ROS production, oxidative marker compared vehicle‐treated Also, we found that...
Abstract Background The role of glycolysis in tumorigenesis has received increasing attention and multiple glycolysis-related genes (GRGs) have been proven to be associated with tumor metastasis. Hence, we aimed construct a prognostic signature based on GRGs for clear cell renal carcinoma (ccRCC) explore its relationships immune infiltration. Methods Clinical information RNA-sequencing data ccRCC were obtained from Cancer Genome Atlas (TCGA) ArrayExpress datasets. Key finally selected...
Di-n-butyl phthalate (DBP) is a kind of ubiquitous chemical linked to hormonal disruptions that affects male reproductive system. However, the mechanism DBP-induced germ cells toxicity remains unclear. Here, we demonstrate DBP induces reduction proliferation, increase apoptosis and DNA damage dependent on PTEN/AKT pathway. Mechanistically, decreases PTEN promoter methylation increases its transcriptional activity, leading increased expression. Notably, DNMT3b confirmed as target miR-29b...
Abstract Background METTL14, as one of N6-methyladenosine (m6A) related genes, has been found to be associated with promoting tumorigenesis in different types cancers. This study was aimed investigate the prognostic value METTL14 clear cell renal carcinoma (ccRCC). Methods We collected ccRCC patients’ clinicopathological parameters information and 13 m6A genes expression from The Cancer Genome Atlas (TCGA) database. Univariate multivariate Cox regression analyses were conducted whether could...
Abstract Background Currently, patients with diabetic erectile dysfunction (DMED) were not satisfied the effects of first‐line phosphodiesterase type 5 inhibitors (PDE5Is). Hence, this paper was designed to mine hub biomarkers in DMED and explore its potential mechanisms. Methods Gene expression matrix downloaded from gene omnibus (GEO; GSE2457) dataset. The top 20 genes selected based on connectivity degrees protein–protein interaction (PPI) network. Functional enrichment analysis utilized...
The advent of high-throughput sequencing methods has facilitated identification novel long non-coding RNAs (lncRNAs), which have been demonstrated to play an important role in multiple tumors. Moreover, with the assistance bioinformatics analysis, LINC01605 found be up-regulated bladder cancer (BC) tissues compared normal tissues. Hence, present study was explore its specific biological and related mechanism BC. relative expression level measured a cohort BC matched as well human cell lines...
Accumulated evidence indicates that miR-455-5p functions as tumor suppressor in the progression of various cancers. However, mechanism through which influences tumorigenesis human prostate cancer (PCa) remains undetermined. In this study, reanalysis data obtained from Memorial Sloan Kettering Cancer Center showed can be used biomarker for PCa diagnosis and predictor poor prognosis. Functional assays indicated overexpression could suppress cellular proliferation, inhibit growth, trigger...
ADAMTS14 played a crucial role in the formation and development of various cancers. Currently, no associations had been revealed between clear cell renal carcinoma (ccRCC). Hence, this study was designed to assess prognostic values immunological roles ccRCC reveal its potential mechanisms. ADAMTS14-related expression profiles related clinical data were downloaded from The Cancer Genome Atlas (TCGA) dataset, validated by ICGC qRT-PCR, immunohistochemistry. We utilized gene set enrichment...
Abstract Background Cell division cycle-associated 7 (CDCA7), as a member of the cell cycle associated family, was reported to be aberrantly expressed in both solid tumors and hematological tumors, suggesting its essential role promoting tumorigenesis. Hence, we aimed explore comprehensive roles overall survival (OS) clear renal carcinoma (ccRCC) emphasize associations with immunity. Methods The RNA sequencing data corresponding clinical information were downloaded from Cancer Genome Atlas...
Background: This study was designed to establish a sensitive prognostic model based on apoptosis-related genes predict overall survival (OS) in patients with clear cell renal carcinoma (ccRCC). Methods: Obtaining the expression of and associated clinical parameters from online datasets (The Cancer Genome Atlas, TCGA), their biological function analyses were performed through differently expressed genes. By means LASSO, unadjusted adjusted Cox regression analyses, this predictive signature...
This article aimed to explore the prognostic and immunological roles of AXL gene in clear cell renal carcinoma (ccRCC) for overall survival (OS) identify LncRNA/RBP/AXL mRNA networks.AXL-related expression matrix clinical data were obtained from The Cancer Genome Atlas (TCGA) dataset AXL-related pathways identified by set enrichment analysis (GSEA). We performed univariate/multivariate Cox regression evaluate independent factors relationships between immunity also investigated.The outcomes...
The aim of this study was to investigate the immunological and prognostic roles protein phosphatase 1 regulatory subunit 18 (PPP1R18) for overall survival (OS) in kidney renal clear cell carcinoma (KIRC) patients, as well prediction its potential mechanisms.Based on PPP1R18 single gene expression matrices clinical information from Cancer Genome Atlas (TCGA), International Consortium (ICGC) GSE6344 datasets, relationships between prognosis/immunity were fully explored. Univariate multivariate...
PTTG1 has been reported to be linked with the prognosis and progression of various cancers, including kidney renal clear cell carcinoma (KIRC). In this article, we mainly investigated associations between prognosis, immunity, in KIRC patients.We downloaded transcriptome data from TCGA-KIRC database. PCR immunohistochemistry were used, respectively, validate expression at line protein levels. Survival analyses as well univariate or multivariate Cox hazard regression used prove whether alone...
The aim of this article was to construct an accurate prognostic model by using RNA-binding proteins (RBPs) predict overall survival (OS) for patients with clear cell renal carcinoma (ccRCC) as well reveal its associations immune infiltration. Expression profiles based on and clinical follow-up parameters were obtained from the Cancer Genome Atlas (TCGA) ArrayExpress databases. Through univariate COX LASSO regression analyses, RBPs signature developed. A total six (CLK2, IGF2BP2, RNASE2,...
Background: Kidney Renal Clear cell carcinoma (KIRC) is a major concern in the urinary system. A lot of researches were focused on Chromatin Regulators (CRs) tumors. In this study, CRs-related lncRNAs ( CRlncRNAs ) investigated for their potential impact prognosis KIRC and immune microenvironment. Methods: The TCGA database was used to obtain transcriptome related clinical information. CRs obtained from previous studies, whereas by differential correlation analysis. We screened signature...
BackgroundApoptosis-related genes (ARGs) were used to develop a novel signature for forecasting overall survival (OS) and examining their relationships with immune infiltrates in bladder cancer (BC).MethodsGene expression matrices as well related clinical data acquired BC samples from online datasets. According differentially expressed ARGs normal tissues samples, functional enrichment analyses conducted. With the assistance of LASSO Cox regression analysis, model was successfully...
Long non-coding RNAs (lncRNAs) play crucial roles in the initiation and progression of renal cell carcinoma (RCC) by competing binding to miRNAs, related competitive endogenous RNA (ceRNA) networks have been constructed several cancers. However, coexpression network has poorly explored RCC.We collected RCC expression profile data relevant clinical features from The Cancer Genome Atlas (TCGA). A cluster analysis was show different lncRNA patterns. Gene ontology (GO), Kyoto Encyclopedia Genes...