A5034690702- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Evolution and Genetic Dynamics
- Viral Infections and Outbreaks Research
- Malaria Research and Control
- Genetic and phenotypic traits in livestock
- Parasite Biology and Host Interactions
- Parasitic Diseases Research and Treatment
- Parasites and Host Interactions
- vaccines and immunoinformatics approaches
- Computational Drug Discovery Methods
- Molecular Biology Techniques and Applications
- Protein Structure and Dynamics
- Mosquito-borne diseases and control
- HIV Research and Treatment
Hochschule Mittweida
2020-2025
Ministry of Public Health
2025
Chemnitz University of Technology
2025
African Institute for Mathematical Sciences
2021-2023
Background Different levels of control measures were introduced to contain the global COVID-19 pandemic, many which have been controversial, particularly comprehensive use diagnostic tests. Regular testing high-risk individuals (pre-existing conditions, older than 60 years age) has suggested by public health authorities. The WHO routine screening residents, employees, and visitors long-term care facilities (LTCF) protect resident risk group. Similar suggestions made for other closed...
Significant progress has been made in onchocerciasis control through mass distribution of ivermectin among affected human populations, fostering optimism for disease elimination. However, despite these considerable advances, the elimination remains a major challenge many African foci. This paper describes current situation Adamaoua Region Cameroon after 20 consecutive years treatment. The study was conducted between August and September 2020 Cameroon. Onchocerciasis endemicity assessed...
Background: The presence of multiple different pathogen variants within the same infection, referred to as multiplicity infection (MOI), confounds molecular disease surveillance in diseases such malaria. Specifically, if molecular/genetic assays yield unphased data, MOI causes ambiguity concerning haplotypes. Hence, statistical models are required infer haplotype frequencies and from ambiguous data. Such methods must apply a general genetic architecture, when aiming condition secondary...
Background Molecular/genetic methods are becoming increasingly important for surveillance of diseases like malaria. Such allow monitoring routes disease transmission or the origin and spread variants associated with drug resistance. A confounding factor in molecular is presence multiple distinct same infection (multiplicity – MOI), which leads to ambiguity when reconstructing pathogenic present an infection. Heuristic approaches often ignore ambiguous infections, biased results. Methods To...
The presence of multiple genetically different pathogenic variants within the same individual host is common in infectious diseases. Although this neglected some diseases, it well recognized others like malaria, where typically referred to as multiplicity infection (MOI) or complexity (COI). In with advent molecular surveillance, data increasingly being available enough resolution capture MOI and integrate into surveillance strategies. distribution on population level scales transmission...
Background COVID-19 vaccines are approved, vaccination campaigns launched, and worldwide return to normality seems within close reach. Nevertheless, concerns about the safety of arose, due their fast emergency approval. In fact, problem antibody-dependent enhancement was raised in context vaccines. Methods findings We introduce a complex extension model underlying pandemic preparedness tool CovidSim 1.1 ( http://covidsim.eu/ ) optimize strategies with regard onset campaigns, coverage,...
Background Governments across the globe responded with different strategies to COVID-19 pandemic. While some countries adopted measures, which have been perceived controversial, others pursued a strategy aiming for herd immunity. The latter is even more controversial and has called unethical by WHO Director-General. Inevitably, without proper control viral diversity increases multiple infectious exposures become common, when pandemic reaches its maximum. This harbors not only potential...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For instance, SNP barcodes in Plasmodium vivax and falciparum malaria allows the characterization haplotypes, their frequencies prevalence to reveal temporal spatial transmission patterns. A confounding factor is presence multiple genetically distinct pathogen variants within same infection, known as multiplicity infection (MOI). Disregarding ambiguous information, usually done ad-hoc approaches,...
After COVID-19 vaccines received approval, vaccination campaigns were launched worldwide. Initially, these characterized by a shortage of vaccine supply, and specific risk groups prioritized. Once supply was guaranteed coverage saturated, the focus shifted from to anti-vaxxers, under-aged population, regions low coverage. At same time, hopes reach herd immunity put into perspective emergence spread more contagious aggressive viral variants. Particularly, concerns raised that not all protect...
Abstract Background Different levels of control measures were introduced to contain the global COVID-19 pandemic, many which have been controversial, particularly comprehensive use diagnostic tests. Regular testing high-risk individuals (pre-existing conditions, older than 60 years age) has suggested by public health authorities. The WHO routine screening residents, employees, and visitors long-term care facilities (LTCF) protect resident risk group. Similar suggestions made for other closed...
Abstract Background COVID-19 vaccines are approved, vaccination campaigns launched, and worldwide return to normality seems within close reach. Nevertheless, concerns about the safety of arose, due their fast emergency approval. In fact, problem antibody-dependent enhancement was raised in context vaccines. Methods findings We introduce a complex extension model underlying pandemic preparedness tool CovidSim 1.1 ( http://covidsim.eu/ ) optimize strategies with regard onset campaigns,...
Abstract Background Governments across the globe responded with different strategies to COVID-19 pandemic. While some countries adapted draconic measures, which have been perceived controversial others pursued a strategy aiming for herd immunity. The latter is even more and has called unethical by WHO Director-General. Inevitably, without proper control measure, viral diversity increases multiple infectious exposures become common, when pandemic reaches its maximum. This harbors not only...
Abstract Molecular/genetic methods are becoming increasingly important for surveillance of diseases like malaria. Such allow to monitor routes disease transmission or the origin and spread variants associated with drug resistance. A confounding factor in molecular is presence multiple distinct same infection (multiplicity – MOI), which leads ambiguity when reconstructing pathogenic present an infection. Heuristic approaches often ignore ambiguous infections, biased results. To avoid such...
Abstract Background After COVID-19 vaccines received approval, vaccination campaigns were launched worldwide. Initially, these characterized by a shortage of vaccine supply, and specific risk groups prioritized. Once supply was guaranteed coverage saturated, the focus shifted from to anti-vaxxers, underaged population, regions low coverage. At same time, hopes reach herd immunity put into perspective emergence spread more contagious aggressive viral variants. Particularly, concerns raised...