A5021857989- Parasitic Diseases Research and Treatment
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Insects and Parasite Interactions
- Insect symbiosis and bacterial influences
- Helminth infection and control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Epilepsy research and treatment
- Zoonotic diseases and public health
- Tuberculosis Research and Epidemiology
- Immune responses and vaccinations
- Bacterial Infections and Vaccines
- Asthma and respiratory diseases
- Biosensors and Analytical Detection
- Malaria Research and Control
- Global Public Health Policies and Epidemiology
- Trauma and Emergency Care Studies
- Cardiovascular Health and Risk Factors
- Child Nutrition and Feeding Issues
- Research on Leishmaniasis Studies
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Emergency and Acute Care Studies
Université de Yaoundé I
2016-2025
Ministry of Scientific Research and Innovation
2023-2025
Ministry of Public Health
2021
Institut de Recherche pour le Développement
2021
Inserm
2021
Université de Montpellier
2021
Hospital for Tropical Diseases
2017
Central Hospital of Yaoundé
2015
Centre Pasteur du Cameroun
1995-2008
Institut de Recherche pour le Développement
2003-2005
After more than a decade of community-directed treatment with ivermectin (CDTI) in Centre and Littoral Regions Cameroon, onchocerciasis endemicity was still high some communities according to the 2011 epidemiological evaluations. Some corrective measures were undertaken improve CDTI process therefore reduce burden disease. The objective present study assess progress made towards elimination 1 2 projects where worst performances found 2011. To this end, cross-sectional survey conducted April...
Although T helper 2 (Th2) cytokines are known to be critical in the generation of protective immunity against intestinal helminths mouse models, it is unclear whether they important natural gut helminthiases humans. Therefore, we investigated cytokine production ex vivo whole-blood cultures response Ascaris lumbricoides antigen and mitogen a cross-section community where parasite hyperendemic. The intensity A. infection was significantly reduced after age 11 years. Levels associated with Th2...
The global burden of onchocerciasis is the heaviest in sub-Saharan Africa. Studies have shown importance role Community-Directed Distributors (CDDs) and nurses control, but little known about their experience implementing control programmes. Our aim was to document barriers that CDDs local health administrators face activities.We conducted a qualitative survey consisting 16 in-depth interviews 8 focus group discussions (FGDs) across three districts Cameroon. We interviewed total 9 officials...
Recent studies in Cameroon after 20 years of implementation the Community Directed Treatment with ivermectin (CDTI) strategy, revealed mixed results as regards community ownership. This brings into question feasibility Interventions (CDI) country. We carried out qualitative surveys 3 health districts Cameroon, consisting 11 individual interviews and 10 Focus Group Discussions (FGDs) specific members. The main topic discussed during FGDs was about participation health. found an gap CDTI...
Some humans are persistently more susceptible to gastrointestinal nematodes than others.Here, for the first time, susceptibility reinfection has been linked host cytokine responses.Ascaris lumbricoides and Trichuris trichiura abundance was assessed immediately before 8-9 months after deworming in a Cameroonian population (starting ).Profiles of whole-blood responses parasite antigens (for interleukin n p 191 [IL]-5, IL-13, IL-10, IL-12p40, tumor necrosis factor-a, interferon-g), assayed...
Increasing immunological dysfunction (atopy and autoimmunity) in western society may be linked to changes undetermined environmental agents. We hypothesize that increased exposure multiple gut worm species promotes stronger regulation. report here African children constitutively secrete more immunoregulatory cytokines (interleukin [IL]-10 transforming growth factor [TGF]- β1) under conditions of hyperendemic the intestinal nematodes Ascaris lumbricoides Trichuris trichiura compared with...
Background Accurate diagnosis of Loa loa infection is essential to the success mass drug administration efforts eliminate onchocerciasis and lymphatic filariasis, due risk fatal encephalopathic reactions ivermectin occurring among highly microfilaremic Loa-infected individuals living in areas co-endemic for multiple filarial species. Methodology/Principal Findings From a pool over 1,800 L. microfilaria (mf) expressed sequence tags, 18 candidate mf-specific PCR targets were identified....
The cytokine and antibody response to Trichuris trichiura infection was determined for 96 persons living in an area where the parasite is highly endemic exhibits a convex age intensity profile. In stimulation with T. antigen, small proportion of study group produced interleukin (IL)-4 (7%), IL-9 (5%), IL-13 (17%). A larger IL-10 (97%), tumor necrosis factor (TNF)-α (93%), interferon (IFN)-γ (32%). levels TNF-α (P = .016) IFN-γ .012) significantly increased age, suggesting switch more chronic...
We followed up the 1996 baseline parasitological and entomological studies on onchocerciasis transmission in eleven health districts West Region, Cameroon. Annual mass ivermectin treatment had been provided for 15 years. Follow-up assessments which took place 2005, 2006, 2011 consisted of skin snips microfilariae (mf) palpation examinations nodules. Simulium vector dissections larval infection rates were done from to 2012. mf prevalence adults dropped 68.7% 11.4%, nodule 65.9% 12.1%. The...
Abstract The effectiveness of the “Slash and Clear” method in reducing blackfly populations low transmission areas is established, but its impact high settings with large rivers dense vectors yet to be proven. A community-based intervention study was conducted Mbam Valley, Centre Cameroon, involving two sites: Bayomen (control) Biatsota (intervention). In each arm, baseline densities were collected over one year using human landing method. consisted destroying trailing vegetation where...
Ivermectin (IVM) is exceptionally safe in humans, and used for mass treatment of onchocerciasis lymphatic filariasis. However, cases encephalopathy, sometimes fatal, have been reported a small number individuals who harbored large numbers Loa loa microfilariae (mf). A loss-of-function mutation the mdr-1 gene some dog breeds mice leads to accumulation drug brain, causing coma death. This hypothesis was tested four from Cameroon experienced post-IVM serious adverse event (SAE) nine non-SAE...
Rapid and accurate tests are currently needed to identify individuals with high levels of Loa loa microfilaria (mf), so that these may be excluded from mass ivermectin administration campaigns against onchocerciasis lymphatic filariasis being conducted in areas where Onchocerca volvulus, Wuchereria bancrofti, L. coendemic. To address this need, colorimetric loop-mediated isothermal amplification (LAMP) assays targeting the loa-specific gene sequences LLMF72 LLMF342 were developed for...
AbstractIvermectin treatment may induce marked adverse effects in those harbouring > 8000 Loa microfilariae (mff)/ml of blood, individuals with 30 000 mff/ml being at risk developing serious neurological reactions. It is thus necessary to delineate the geographical areas where such responses occur. To determine if simple measure prevalence microfilaraemia would be appropriate identify communities risk, relationships between and intensity were investigated 67 villages Cameroon. The recorded...
After more than 15 years of community-directed treatment with ivermectin (CDTI) in the Centre 1, Littoral 2 and West CDTI projects Cameroon, epidemiological evaluation conducted 2011 revealed that onchocerciasis endemicity was still high some communities. To investigate potential reasons explaining this endemicity, a cluster coverage survey April-May 2015 three health districts (HD), to assess implementation CDTI, 2014 therapeutic five-year adherence treatment. A two-stage design considered...
Background Loiasis is a parasitic infection endemic in the African rain forest caused by filarial nematode Loa loa. can be co-endemic with onchocerciasis and/or lymphatic filariasis. Ivermectin, drug used control of these diseases, induce serious adverse reactions patients high L loa microfilaraemia (LLM). A needed which lower LLM below level that represents risk so ivermectin mass treatment to support and filariasis elimination implemented safely. Methodology Sixty men women from loiasis...
Severe adverse reactions have been observed in individuals with Loa loa infection treated either diethylcarbamazine (DEC), the drug of choice for loiasis, or ivermectin (IVM), which is used mass administration programs control onchocerciasis and lymphatic filariasis Africa. In this study, posttreatment clinical immunologic were compared following single-dose therapy DEC IVM to assess whether these same underlying pathophysiology. Twelve patients loiasis microfilarial counts <2000 mf/mL...
Diagnostic tools for lymphatic filariasis (LF) elimination programs are useful in mapping the distribution of disease, delineating areas where mass drug administrations (MDA) required, and determining when to stop MDA. The prevalence burden LF have been drastically reduced following treatments, evaluation performance circulating filarial antigen (CFA)-based assays was acknowledged be high interest with low residual endemicity rates after multiple rounds objective this study therefore...
Soil-transmitted helminthiases (STHs) are among the most prevalent afflictions of developing world, with approximately 2 billion people infected worldwide. Heavily individuals suffer from severe morbidity that can result in death. These parasitic diseases also impair physical and mental growth childhood, thwart educational advancement, hinder economic development. Periodic deworming Albendazole or Mebendazole high-risk groups (school-age children, preschool pregnant women) significantly...
In Cameroon, since the first epidemiological week held in 2015, snakebites have been registered among Potential Epidemic Diseases (PED). Centre Region, most densely populated of country, weekly reports are generated at health districts level for monthly data updates. To contribute to better management snakebite cases, an observational study was conducted assess reporting rate Region Cameroon. The results this retro-prospective survey were confronted those surveillance system, recorded PED...
Schistosomiasis control currently relies on school-based preventive chemotherapy (PC) with praziquantel, which has been proven, unfortunately, insufficient to interrupt disease transmission in areas persistent transmission. In the Ndikinimeki Health District (Centre Region, Cameroon), complementary strategies (community-based chemotherapy, water sanitation, hygiene, and health education) have also implemented accelerate interruption of schistosomiasis this focus. The assessment impact...
Significant progress has been made in onchocerciasis control through mass distribution of ivermectin among affected human populations, fostering optimism for disease elimination. However, despite these considerable advances, the elimination remains a major challenge many African foci. This paper describes current situation Adamaoua Region Cameroon after 20 consecutive years treatment. The study was conducted between August and September 2020 Cameroon. Onchocerciasis endemicity assessed...
Accurate diagnostics are essential for disease control and elimination efforts. However, access to neglected tropical diseases (NTDs) is hindered by limited healthcare infrastructure in many NTD-endemic regions, as well reliance on time- labor-intensive diagnostic methods, such smear microscopy. New tools that portable, rapid, low-cost, meet World Health Organization (WHO) sensitivity specificity targets urgently needed accelerate NTD programs. Here, we introduce the NTDscope, a portable...