A5043292112- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Mitochondrial Function and Pathology
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- ATP Synthase and ATPases Research
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Colorectal Cancer Treatments and Studies
- Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Biochemical and Molecular Research
- Ion channel regulation and function
- Gastric Cancer Management and Outcomes
- Medical Imaging Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Pituitary Gland Disorders and Treatments
- Myasthenia Gravis and Thymoma
- Connexins and lens biology
- S100 Proteins and Annexins
- Fungal Plant Pathogen Control
Osaka University
1988-2025
Nagoya City University
2017-2023
University of the Ryukyus University Hospital
2017
Iwate Medical University
2016
Chiba Cancer Center
2010-2014
Neurological Surgery
2012-2014
Sasaki Institute
1999
National Institute of Infectious Diseases
1996
Background Circulating tumor DNA (ctDNA) carries information on burden. However, the mutation spectrum is different among tumors. This study was designed to examine utility of ctDNA for monitoring burden based an individual profile. Methodology extracted from a total 176 samples, including pre- and post-operational plasma, primary tumors, peripheral blood mononuclear cells (PBMC), 44 individuals with colorectal who underwent curative resection as well nine healthy individuals. Using panel 50...
Lung cancer is a common type of that represents health problem worldwide; lung adenocarcinoma (LUAD) major subtype cancer. Although several treatments for LUAD have been developed, the mortality rate remains high because uncontrollable progression. Further biological and clinicopathological studies are therefore needed. Here, we investigated role family with sequence similarity 111 member B (FAM111B), which highly expressed in papillary-predominant LUAD; however, its unclear. An...
Although annexin A1 (ANXA1) is known to mediate inflammatory responses through N-formyl peptide receptor 2 (FPR2), the role of ANXA1-FPR2 signaling pathway in periodontal disease remains unclear. This study investigated contribution this pathophysiology disease. Using a ligature-induced mouse model, we performed histologic analyses examine ANXA1 and FPR2 expression. We observed upregulation within gingiva ligament. In vitro analysis human ligament cells revealed that interleukin 1β...
In a previous study, we purified PAF-acetylhydrolase, which converts PAF to an inactive metabolite, lysoPAF, from peritoneal fluid of guinea pigs subjected experimental endotoxin shock and found that this enzyme had similar biochemical properties the plasma [Karasawa, K., Yato, M., Setaka, Nojima, S. (1994) J. Biochem. 116,374–379]. isolated homogeneous preparation pig using procedure. The molecular mass enzyme, as determined by SDS-PAGE was 58–63 kDa, larger than (43 kDa) human enzyme. To...
Spatiotemporal changes in cytosolic Ca 2+ concentration ([Ca ] c ) trigger a number of physiological functions smooth muscle cells (SMCs). We previously imaged -induced release following membrane depolarization as local transients, hotspots, subplasmalemmal regions. In this study, the significance mitochondria on signaling was examined. Cytosolic and mitochondrial images or action potentials were recorded single SMCs from guinea pig urinary bladder using fast-scanning confocal fluorescent...
// Takuya Shintani 1, 2 , Kazuma Higashisaka 3 Makiko Maeda 1 Masaya Hamada Ryosuke Tsuji Koudai Kurihara Yuri Kashiwagi Atsuhiro Sato Masanori Obana Ayaha Yamamoto Keisuke Kawasaki 4 Ying Lin Takashi Kijima 5, 6 Yuhei Kinehara Yoshihiro Miwa Shinichiro Eiichi Morii Atsushi Kumanogoh 6, 7 Yasuo Tsutsumi 8 Izumi Nagatomo and Yasushi Fujio Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan Department Pharmacy, University Hospital, Legal Medicine, Pathology, 5 Division...
Some reports showed encouraging efficacy of immune checkpoint inhibitors among patients who experienced immune-related adverse events (irAEs). Thus, characterization T-cell repertoire and signatures in peripheral blood mononuclear cells (PBMCs) tumors before after treatment should contribute to better understanding irAE-provoked anticancer responses.We applied expression analysis genes receptor sequencing tumor PBMCs from five with renal cell carcinoma combined immunotherapy at the onset...
Mitochondria buffer cytosolic Ca 2+ increases following influx from extracellular spaces, and release intracellular store sites under physiological circumstances. Therefore, close contact of mitochondria with the sarcoplasmic reticulum (SR) is required for maintaining homeostasis. Mitofusin 2 (Mfn2) localizes in both mitochondrial SR membranes hypothesized to optimize distance transfer between these organelles. However, significance Mfn2 vascular smooth muscle cells (VSMCs) poorly...
We have been performing PDT using Excimer Dye Laser (EDL) or YAG-OPO laser, a type of low power both which considerably higher degree tissue penetration even when compared to Argon (ADL).PDT is relatively simple procedure without any bleeding and does not require anesthesia since it causes no pain. performed 48 h after intravenous injection 1.5-2.0 mg/kg PHE (Photofrin((R))). Precise spot irradiation possible colposcope with an optical laser path. also use cervical probe enables...
Adenocarcinoma is the most common histological type of lung cancer and has various histologic subtypes, including lepidic, papillary, acinar invasive mucinous adenocarcinoma. Histologic subtypes are associated with tumor invasiveness. For example, lepidic subtype less than papillary/acinar subtype. Trefoil factor 3 (TFF3) a small secreting protein that member trefoil family, which involved in mucosal stabilization repair through its mitogenic antiapoptotic activities. TFF3 overexpression...
症例は81歳の女性で，上部消化管出血による出血性ショックから多臓器不全を発症し集中治療を受けた．全身状態が改善した後に施行された上部消化管内視鏡検査で幽門部に隆起性病変の存在が確認され，生検でgroupVが検出された．各種画像検査で胃の軸捻転と胸腔内への逸脱が確認されたためにupside down stomachに併発した早期胃癌と診断され，腹腔鏡下に幽門側胃切除術を行った．術後に逆流性食道炎の発症が懸念されたため再建はRoux-en-Y法が選択された．最終病理組織診断はtype0-IIc+IIa pT1apN0M0，ly0，v0，Stage IAだった．Upside stomachを伴う早期胃癌に対しても腹腔鏡下手術は有用な選択肢の一つであると考えられた．
Two-pore domain K+ (K2P) channels are thought to be druggable targets. However, only a few agents specific for K2P have been identified, presumably due the lack of an efficient screening system. To develop new high-throughput (HTS) system targeting these channels, we established HEK293-based "test cell" expressing mutated Na+ channel (Nav1.5) with markedly slowed inactivation, as well (Kir2.1) that sets membrane potential quite negative, close equilibrium potential. We found in this Kir2.1...
Introduction Carcinoma of unknown primary site is a heterogeneous group cancer that defined by the presence metastatic disease with no identified tumor at initial presentation. patients unfavorable subsets particularly show poor prognosis median survival 6–9 months treatment empirical pactitaxel and carboplatin therapy (TC therapy). Recently, several studies have attempted to increase response rate on basis prediction immunohistochemical tests or molecular profiling assays. Case presentation...
Abstract The relationship between thymic epithelial tumour and demyelinating disease (DD) is unknown surgical resection has not been optimized. A 39‐year‐old woman was administrated methylprednisolone for newly diagnosed multiple sclerosis. found in the antero‐superior mediastinum via computed tomography of chest. Video‐assisted thoracoscopic thymectomy performed. Histologically, as Type AB thymoma. Immunohistochemical staining showed positive myelin basic protein (MBP) cytosol spindle cells...