A5047884679- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Phosphodiesterase function and regulation
- Ion channel regulation and function
- Sexual function and dysfunction studies
- Cholinesterase and Neurodegenerative Diseases
- Diet and metabolism studies
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
- Gut microbiota and health
- Adenosine and Purinergic Signaling
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Medicinal Plants and Neuroprotection
- Pharmacological Receptor Mechanisms and Effects
- Zebrafish Biomedical Research Applications
- Bipolar Disorder and Treatment
- Neuroendocrine regulation and behavior
- Cannabis and Cannabinoid Research
- Probiotics and Fermented Foods
- Ion Channels and Receptors
Maria Curie-Skłodowska University
2016-2025
University of Veterinary Medicine Hannover, Foundation
2014
Recently, compound KA-11 was identified as a promising candidate for new broad-spectrum anticonvulsant. This revealed wide protective activity across the most important animal models of seizures such maximal electroshock test (MES), subcutaneous pentylenetetrazole (scPTZ), and six-hertz (6 Hz, 32 mA). Importantly, devoid acute neurological activity, which assessed by applying chimney (TD50 value higher than 1500 mg/kg). The preliminary in vivo results confirmed favorable anticonvulsant...
Pterostilbene (PTE), a natural dimethylated analog of resveratrol, possesses numerous health-beneficial properties. The ability PTE to cross the blood-brain barrier raised possibility that this compound may modulate central nervous system functions, including seizure activity. aim our study was investigate activity in larval zebrafish pentylenetetrazole (PTZ) assay and three acute tests mice, i.e., maximal electroshock threshold (MEST), 6 Hz-induced psychomotor intravenous (iv) PTZ tests....
Pterostilbene is the 3,5-dimethoxy derivative of resveratrol with numerous beneficial effects including neuroprotective properties. Experimental studies revealed its anticonvulsant action in acute seizure tests.The purpose present study was to evaluate effect pterostilbene pentetrazol (PTZ)-induced kindling model epilepsy mice as well assess some possible mechanisms this model.Mice were repeatedly treated (50-200 mg/kg) and on development activity PTZ estimated. Influence locomotor anxiety-...
α-Spinasterol is a plant-derived compound which was reported to act as selective antagonist for the transient receptor potential vanilloid 1 (TRPV1) receptor. Several studies revealed that TRPV1 receptors might modulate seizure activity in animal models of seizures and epilepsy. The aim present study investigate effect α-spinasterol on threshold three acute seizures, i.e., intravenous (i.v.) pentylenetetrazole (PTZ) test, maximal electroshock (MEST) test model psychomotor induced by 6 Hz...
(R)-7 [(R)-AS-1] showed broad-spectrum antiseizure activity across in vivo mouse seizure models: maximal electroshock (MES), 6 Hz (32/44 mA), acute pentylenetetrazol (PTZ), and PTZ-kindling. A remarkable separation between CNS-related adverse effects was also observed. In vitro studies with primary glia cultures COS-7 cells expressing the glutamate transporter EAAT2 enhancement of uptake, revealing a stereoselective positive allosteric modulator (PAM) effect, further supported by molecular...
Studies have revealed that inhibition of glycine transporter type 1 (GlyT1) may provide a balanced regulation between excitation and in some brain structures and, thereby, modulate seizure activity. Data on the role GlyT1 epilepsy are, however, very limited. Here, we examined effect SSR504734, highly selective reversible inhibitor, three acute tests mice. We also evaluated its impact neurotransmitter levels relevant following seizures, possible adverse effects, changes inflammatory mediators...
Apigenin is a natural flavonoid with various pharmacological properties. Available data indicate that it affects the metabolic processes and protein profile of cells, including hepatocytes. However, there speculation use apigenin may have hepatotoxic effect. The aim experiment was to assess effect administered intraperitoneally mice on concentrations pro- anti-inflammatory cytokines in liver tissue analyse weight morphological changes parenchyma. A proteomic analysis also performed examine...
Ganoderma lucidum is a well-known medicinal mushroom with long history of use. This study was designed to assess the anticonvulsant potential an aqueous extract from cultured G. mycelium in 3 acute seizure models: timed intravenous pentylenetetrazole infusion, maximal electroshock threshold, and 6-Hz-induced psychomotor tests mice. Moreover, antidepressant-like anxiolytic-like effects were evaluated using forced swim test elevated plus maze mice, respectively. No changes thresholds threshold...
Epilepsy is one of the most common neurological disorders which diagnosed in around 65 million people worldwide. Clinically available antiepileptic drugs fail to control epileptic activity about 30% patients and they are merely symptomatic treatments cannot cure or prevent epilepsy. There remains a need for searching new therapeutic strategies disorders. The P2X7 receptor has been recently investigated as target epilepsy treatment. Preclinical studies revealed that antagonists have...
Tadalafil, a selective phosphodiesterase type 5 inhibitor, is long-acting oral agent for the treatment of erectile dysfunction multiple etiologies. Although generalized tonic-clonic seizures were reported in healthy man after taking tadalafil, influence tadalafil on seizure susceptibility has not been studied so far. Therefore, aim present study was to investigate effect threshold as well activity some first- and second-generation antiepileptic drugs three acute tests mice. The obtained...
In our recent studies, we identified compound N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) as a broad-spectrum hybrid anticonvulsant which showed potent protection across the most important animal acute seizure models such maximal electroshock (MES) test, subcutaneous pentylenetetrazole (s.c. PTZ) and 6-Hz (32 mA) test in mice. Therefore, AS-1 may be recognized candidate for new effective different types of human epilepsy with favorable safety margin profile determined rotarod aim...