A5100382614- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Plant-based Medicinal Research
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Berberine and alkaloids research
- Medicinal Plant Pharmacodynamics Research
- Gut microbiota and health
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Analytical Chemistry and Chromatography
- Traditional Chinese Medicine Studies
- Liver Disease Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Toxic Organic Pollutants Impact
- Plant chemical constituents analysis
- Animal Virus Infections Studies
- Food Quality and Safety Studies
- Computational Drug Discovery Methods
- Viral gastroenteritis research and epidemiology
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and biological activity of medicinal plants
- Virus-based gene therapy research
- Nephrotoxicity and Medicinal Plants
Tianjin University of Traditional Chinese Medicine
2018-2025
Michigan State University
2025
Guangxi University
2025
Southwest Petroleum University
2024
Tianjin haihe hospital
2023-2024
Xiaomi (China)
2023
Chongqing Medical University
2020
University of California, Davis
2018-2019
Peking University First Hospital
2014
Peking University
2014
Rapid access chest pain clinics (RACCs) are an innovative outpatient pathway that allows low-intermediate risk patients to avoid hospitalisation. However, the extent of RACCs in Australia is unknown. We aimed identify Australian and describe characteristics landscape this model care Australia. were identified through four pathways: 1) Systematic literature search; 2) Google Search; 3) Word mouth via RACC leaders including National Health Medical Research Council Translation Centres form...
ABSTRACT Coreopsis tinctoria Nutt. (CT) has the effects of clearing heat and detoxifying, which can be used to treat red‐eye swelling. At present, there are studies on CT treatment diabetic retinopathy (DR). Diabetes affect function eyes, is closely related liver. The connection between liver eyes valued as liver–eye axis. There no reports mechanism action in DR. This study analyzed differences DR rats before after administration using network pharmacology, LC‐MS‐based non‐targeted...
ABSTRACT Diabetes retinopathy (DR) is one of the serious complications diabetes. Clinical practice has proved that Tang Wang Ming Mu Granule (TWMM) can improve symptoms DR patients. The mechanism TWMM in treating mice was studied, combining gut microbiota with metabolomics. A high‐fat and high‐sugar diet combined streptozotocin (STZ) injection used to create a mouse model DR. C57BL6/J wild‐type were divided into five groups, including normal control, model, (2.7 10.8 g/kg) treatment,...
Epimedium herb is one of the most vital traditional Chinese medicines (TCMs), which used for “nourishing kidney and reinforcing Yang”. In guidance TCM theory, usually processed with lamb oil to increase its efficacy. The contents active ingredients in different are significantly varied, may derive from their species, regions processing methods. this research, 13 batches raw collected 6 provinces were identified. After optimization method Epimedium, a liquid chromatography⁻mass spectrometry...
A rapid and reliable HPLC-MS/MS method has been developed validated for the simultaneous quantification of twelve bioactive compounds (baohuoside II, baohuoside I, sagittatoside A, B, magnoflorine, epimedin C, chlorogenic acid, neochlorogenic cryptochlorogenic acid icariin) in rat plasma. The collected plasma samples were prepared by protein precipitate with acetonitrile. separated on a CORTECS®C18 column (4.6 mm × 150 mm, 2.7 μm) gradient mobile phase system 0.1% (v/v) formic acetonitrile...
To report the decline of renal function after radical nephroureterectomy (RNU) in upper tract urothelial carcinoma (UTUC) patients and to develop a nomogram predict ineligibility for cisplatin-based adjuvant chemotherapy (AC).We retrospectively analyzed 606 consecutive Chinese UTUC treated by RNU from 2000 2010. We chose an eGFR 60 45 ml/min/1.73 m(2) as cut-offs full-dose reduced-dose AC eligibility.Median all before surgery was 64 49 (P < 0.001). The proportion ineligible receive changed...
Environmental toxicants that interfere with thyroid hormone (TH) signaling can impact growth and development in animals humans. Zebrafish represent a model to study chemically induced TH disruption, prompting the need for sensitive detection of THs. Simultaneous quantification 3,3',5-triiodo-l-thyronine (T3), thyroxine (T4), 3,3',5'-triiodo-l-thyronine (rT3), 3,5-diiodo-l-thyronine (3,5-T2) 3,3'-diiodo-l-thyronine (3,3'-T2) zebrafish larvae was achieved by ultra-performance liquid...
A sensitive and reliable HPLC-MS/MS method has been developed validated for simultaneous determination of eleven bioactive compounds (rhein, emodin, stilbene glycoside, liquiritin, ononin, verbascoside, gallic acid, schisandrin, liquiritigenin, glycyrrhizic isoliquiritigenin) in rat plasma after oral administration Tongmai Yangxin Pill. The collected samples were prepared by liquid-liquid extraction with ethyl acetate acidification. Eleven separated on a CORTECS™ C18 column mobile phases...
Network pharmacology was used to illuminate the targets and pathways of polybrominated diphenyl ethers (PBDEs) causing thyroid dysfunction. A protein-protein interaction (PPI) network constructed. Molecular docking applied analyze PBDEs key according results. total 247 were found be related 16 PBDEs. Ten with direct action identified, including top five PIK3R1, MAPK1, SRC, RXRA, TP53. Gene Ontology (GO) functional enrichment analysis identified 75 biological items. Kyoto Encyclopedia Genes...
Xuanfei Baidu granule (XFBD) is a recommended patented drug for the prevention and treatment of Corona Virus Disease 2019 (COVID-19), which approved by National Medical Products Administration. XFBD suppresses over-activated immune response caused inflammatory factor storms in COVID-19 infection. The intestine plays crucial role system. mass spectrometry based fecal metabolomics with 16S rDNA sequencing were combined to evaluate effects on host metabolism gut microbiome. Short-chain fatty...
Hydraulic fracturing is a key technology for the development of tight reservoirs. Affected by factors such as volcanic activity and tectonic movements, rock reservoirs have characteristics diverse lithofacies, complex mineral compositions, well-developed natural fractures. The effectiveness reservoir stimulation largely depends on its ability to connect with fractures form fracture network. In this study, in order clarify propagation behavior reservoirs, experiment was performed specimens...
Uric acid (UA) is the final product of purine metabolism in humans. Elevated serum UA levels lead to development hyperuricemia, gout, kidney diseases, and metabolic syndrome. Accurate determination plays a critical role clinical diagnosis laboratory investigation. An ultra-performance liquid chromatography (UPLC) with ultraviolet detection method has been developed validated for analysis. Separation was achieved by Waters ethylene bridged hybrid (BEH) Amide column (50 mm × 2.1 i.d., 1.7 μm)...
Angelicae pubescentis radix (APR) is widely applied in treating rheumatoid arthritis China. Coumarins are the major active compounds of APR extract including columbianetin, columbianetin acetate, osthole, and columbianadin. The vivo behavior four coumarins has not been systematically reported. A feasible reliable ultra-performance liquid chromatography (UPLC) method was established validated for quantification above rat various tissues (including heart, liver, spleen, lung, kidney, uterus,...
A high-throughput HPLC-MS/MS method was developed and validated for the determination of four antihypertensive drugs including metoprolol tartrate, hydrochlorothiazide, nifedipine, valsartan in rat plasma. The Sprague-Dawley rats were randomly divided into three groups: Group: gastric-administration or valsartan; B a single intravenous injection SXT, then dosing as group; C daily SXT through tail vein 8 consecutive days group on eighth day. For tartrate valsartan, blood samples collected...
Abstract The identification and quantization of traditional Chinese medicine (TCM) are a challenge for researchers industry. Using untargeted analytical methods, the in vivo detection TCM compounds difficult because significant interference endogenous substances. Fortunately, ongoing development new technologies, especially Q‐Orbitrap–MS, offers some solutions. Our team developed holistic MS method, combining data‐dependent 2 (dd‐MS ) modes to extensively identify prototypes vivo. method was...