A5045757605- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Structural Anomalies and Repair
- Peripheral Artery Disease Management
- Cardiac Ischemia and Reperfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Vascular Procedures and Complications
- Cardiovascular Issues in Pregnancy
- Angiogenesis and VEGF in Cancer
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Function and Risk Factors
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac electrophysiology and arrhythmias
- Advanced biosensing and bioanalysis techniques
- Aortic aneurysm repair treatments
- Atherosclerosis and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- RNA Interference and Gene Delivery
- Cardiac Arrest and Resuscitation
- Cardiac Arrhythmias and Treatments
- Signaling Pathways in Disease
Concord Repatriation General Hospital
2016-2025
Royal Prince Alfred Hospital
2006-2025
Western NSW Local Health District
2019-2025
The University of Sydney
2014-2024
Royal North Shore Hospital
2023
Concord Hospital
2003-2023
Florida Department of Health in Orange County
2023
Anzac Research Institute
2006-2015
Institute for Urban Indigenous Health
2015
GTx (United States)
2014
AimsWe investigated whether three-dimensional (3D) and two-dimensional quantitative coronary angiography (2D-QCA) measurements differed in their accuracy predicting reduced fractional flow reserve (FFR), how this varied with stenosis severity the FFR cut-off used.
Early growth response factor-1 (Egr-1) controls the expression of a growing number genes involved in pathogenesis atherosclerosis and postangioplasty restenosis. Egr-1 is activated by diverse proatherogenic stimuli. As such, this transcription factor represents key molecular target efforts to control vascular lesion formation humans. In study, we have generated DNAzymes targeting specific sequences human EGR-1 mRNA. These molecules cleave vitro transcribed mRNA efficiently at preselected...
Rapid access chest pain clinics (RACCs) are an innovative outpatient pathway that allows low-intermediate risk patients to avoid hospitalisation. However, the extent of RACCs in Australia is unknown. We aimed identify Australian and describe characteristics landscape this model care Australia. were identified through four pathways: 1) Systematic literature search; 2) Google Search; 3) Word mouth via RACC leaders including National Health Medical Research Council Translation Centres form...
Percutaneous transluminal coronary angioplasty is a frequently used interventional technique to reopen arteries that have narrowed because of atherosclerosis. Restenosis, or renarrowing the artery shortly after angioplasty, major limitation success procedure and due mainly smooth muscle cell accumulation in wall at site balloon injury. In present study, we demonstrate antiangiogenic sulfated oligosaccharide, PI-88, inhibits primary vascular proliferation reduces intimal thickening 14 days...
Animal models of cardiovascular pathology contribute towards understanding and treatment a broad range conditions. Specifically in the context acute myocardial infarction (AMI), rat have been commonly used studies pathogenesis, investigation novel therapies, although there has often difficulty translating experimental findings to clinical benefit. However, recent years seen two important changes our approaches AMI. First, is increasing recognition that pathophysiology human AMI process...
Coronary reperfusion has been the mainstay therapy for reduced infarct size after a heart attack. However, this intervention also results in myocardial injury by initiating marked inflammatory reaction, and new treatments are keenly sought.The basic-region leucine zipper protein, c-Jun is poorly expressed normal myocardium induced within 24 hours ischemia-reperfusion injury. Synthetic catalytic DNA molecules (DNAzymes) targeting (Dz13) reduce area-at-risk (AAR) regardless of whether it...
Background Remote ischemic preconditioning (RIPC) attenuates myocardial damage during elective and primary percutaneous coronary intervention. Recent studies suggest that microcirculatory function is an important determinant of clinical outcome. The aim this study was to assess the effect RIPC on markers function. Methods Results Patients referred for cardiac catheterization fractional flow reserve measurement were randomized or sham. Operators patients blinded treatment allocation....