The continuous presence of bacteria or their degraded antigens in the synovium may be involved pathogenesis rheumatoid arthritis (RA). aim this study was to determine bacterial nucleic acids and cell wall constituents joints patients with RA other forms arthritis.Joint samples were obtained from (n = 26), septic 2), inflammatory osteoarthritis 5), gout 6), joint trauma 1). Universal 16S-ribosomal RNA primers used detect DNA these samples, using stringent regimens for sample collection...

To determine protein and activity levels of matrix metalloproteinases 1 3 (MMP-1 MMP-3) in synovial fluid patients with knee joint injury, primary osteoarthritis, acute pyrophosphate arthritis (pseudogout).Measurements were done on obtained a cross sectional study cases injury (n = 283), osteoarthritis 105), pseudogout 65), healthy controls 35). Activity MMP-1 MMP-3 alpha(2) macroglobulin complexes was measured using specific low molecular weight fluorogenic substrates. ProMMP-1, proMMP-3,...

<b>Objective:</b> To analyse matrix metalloproteinases (MMPs) and tissue inhibitor-1 of MMPs (TIMP-1) levels in the systemic circulation synovial fluid (SF) patients with RA to compare these inflammatory collagen degradation markers. <b>Methods:</b> ProMMP-1, -2, -3, -8, -9, TIMP-1, MMP/α₂-macroglobulin complexes, products were measured by sandwich ELISA, activity assays, HPLC paired SF serum samples from 15 13 OA. <b>Results:</b> higher than OA or controls. MMP In serum,...

To analyse the relation between systemic levels of pro-MMP-3, -8, and -9 matrix metalloproteinase (MMP) activity in alpha(2) macroglobulin (alpha(2)M)/MMP complexes progression joint destruction patients with recent onset rheumatoid arthritis (RA).109 RA were entered into this longitudinal study. Patients followed up for two years; clinical data, blood samples, radiographs obtained at baseline 1 2 years. Serum MMPs measured by sandwich ELISA MMP assays.During years damage progressed from 0...

Objectives The aim of this study is to evaluate the effectiveness two tapering strategies after achieving controlled disease in patients with rheumatoid arthritis (RA), during 1 year follow-up. Methods In multicentre single-blinded (research nurses) randomised trial, RA were included who achieved disease, defined as a Disease Activity Score (DAS) ≤ 2.4 and Swollen Joint Count (SJC) 1, treated both conventional synthetic disease-modifying antirheumatic drugs (csDMARD) TNF inhibitor. Eligible...

The prevalence of psoriatic arthritis (PsA) is the same in men and women; however, latter experience a higher burden disease are affected more frequently by polyarthritis. Here, we performed an early PsA cohort analysis to assess sex-related differences demographics, characteristics, evolution over 1 year including applied treatment strategies.Our study embedded Dutch south-west Early Psoriatic Arthritis cohoRt. We described patient characteristics decisions. For comparison across sexes...

Objectives To investigate whether there is a window of opportunity for psoriatic arthritis (PsA) patients and to assess which patient characteristics are associated with longer diagnostic delay. Methods All newly diagnosed, disease-modifying antirheumatic drug-naïve PsA who participated in the Dutch southwest Early cohoRt had ≥3 years follow-up were studied. First, total delay was calculated as time period between symptom onset diagnosis made by rheumatologist then split into physician...

Objective. Psoriatic arthritis (PsA) is a multifaceted disease. Affecting joints, skin, entheses, and dactylitis, its effect on health-related quality of life (HRQOL) could be substantial. We aim to assess HRQOL in patients newly diagnosed with PsA analyze associations disease manifestations. Methods. Data collected at time diagnosis from included the Dutch south-west Early Arthritis cohort (DEPAR) study were used. was assessed using 8 domains Medical Outcomes Study Short Form-36 (SF-36)...

Objectives With early and intensive treatment many patients with RA attain remission. Aims were to investigate (1) the frequency time sustained remission subsequent tapering in initially treated conventional synthetic disease modifying anti-rheumatic drug ((cs)DMARD) strategies (2) flare regained csDMARDs biological (b)DMARDs during 2 years of follow-up. Methods Two-year follow-up data from Rotterdam Early Arthritis Cohort (tREACH) cohort used. Patients randomised initial triple DMARD...

. To compare the screening performance of Psoriasis Epidemiology Screening Tool (PEST), Psoriatic Arthritis and Evaluation (PASE) Early for Patients (EARP) questionnaires detecting PsA among psoriasis patients in a primary care setting.In cross-sectional study, 473 at risk completed PEST, PASE EARP were clinically evaluated by trained research nurse. A case was defined rheumatologist according to CASPAR criteria. Sensitivity specificity determined PEST cut-offs (⩾3) (⩾44 ⩾47).PsA diagnosed...

Methotrexate (MTX) is widely used as first-line treatment in psoriatic arthritis (PsA). Despite the variable efficacy of MTX PsA compared to newer therapeutic agents, its affordability and availability make it crucial, especially resource-limited healthcare settings. Identification factors associated with non-response could facilitate early redirection more effective therapy. This study aimed identify baseline clinical, demographic, psychosocial variables 3 months after initiation a...

Objective Rheumatoid arthritis (RA) and psoriatic (PsA) are currently treated similarly. However, it is unclear which patient-reported outcome (PRO) domains need specific attention in the management of RA PsA. Therefore, we aimed to determine difference disease impact between matched PsA patients at diagnosis after 1 year two different regions. Methods from treatment Rotterdam Early Arthritis CoHort trial (tREACH), Dutch southwest cohoRt (DEPAR) Leiden Clinic (EAC) were included. The was...

Objective To evaluate the effect of achieving Minimal Disease Activity (MDA) within first year on radiologic damage at follow-up 3 years in patients with newly diagnosed Psoriatic Arthritis (PsA). Methods Data were used from Dutch southwest Early PsA cohort, a real-world cohort patients, focusing for this manuscript those oligoarthritis or polyarthritis. Patients stratified into three groups: [1] Sustained-MDA– MDA least both 9 and 12 months post-diagnosis; [2] Non-sustained-MDA– but not...

According to current management guidelines for psoriatic arthritis (PsA) tapering of disease-modifying antirheumatic drugs (DMARDs) can be considered. However, limited data are available on complete DMARD cessation, also known as drug-free remission (DFR). Therefore, our aim was investigate whether DFR is achievable and sustainable in PsA evaluate possible predictors sustained (SDFR). From the Dutch southwest Early Psoriatic Arthritis cohort, all newly diagnosed patients with...

We aimed to describe sonographic structural and inflammatory changes in entheses of patients with recently diagnosed psoriatic arthritis (PsA), established PsA, young healthy volunteers, investigate whether the MAdrid Sonographic Enthesitis Index (MASEI) enables us distinguish these groups an extreme comparison.New PsA volunteers (aged 20-30 years) were recruited. The triceps, quadriceps, patellar, Achilles elbow extensor tendon insertion, plantar fascia investigated sonographically for...

Abstract Objectives To compare responsiveness and longitudinal validity of Disease Activity Score 28 (DAS28), index for PSoriatic Arthritis (DAPSA), Composite Psoriatic Index (CPDAI), ArthritiS (PASDAS), GRAppa scorE (GRACE) Minimal (MDA) in usual care PsA patients, within 1 year after diagnosis. Methods Data collected the Dutch southwest early cohort (DEPAR) were used. Responsiveness was assessed using effect size (ES), standardized response mean (SRM), discrimination between different...

The impact of inflammatory arthritis (IA) on male fertility remains unexplored. Our objective was to evaluate the IA several outcomes; rate (number biological children per man), family planning, childlessness and problems.We performed a multicentre cross-sectional study (iFAME-Fertility). Men with 40 years or older who indicated that their size complete were invited participate. Participants completed questionnaire included demographic, medical fertility-related questions. To analyse rate,...

Objective Persistent articular inflammation in psoriatic arthritis (PsA) is associated with radiographic damage. Despite advances diagnosis and therapy, structural damage remains prevalent PsA. To elucidate this topic, we studied which baseline clinical characteristics determine progression. Methods For analysis, data were used from DEPAR (Dutch South West Psoriatic Arthritis) Study, a real-world cohort of patients newly diagnosed Radiographic changes assessed using the modified Total...

To estimate the prevalence of psoriatic arthritis (PsA) in primary care patients diagnosed as having psoriasis and to musculoskeletal symptoms care.We conducted a cross-sectional study adult with psoriasis. Responding reporting pain joints, entheses, or lower back were interviewed by telephone determine eligibility and, if eligible, invited for clinical evaluation. During evaluation, skin, nails, entheses assessed. Additionally, ultrasound enthesis was performed an independent trained...

Objective. Enthesitis is a manifestation of psoriatic arthritis (PsA), but its symptoms are difficult to interpret clinically. We investigated the associations ultrasonographic changes in entheses with clinical characteristics patients PsA, and compared enthesis aged 35 60 years healthy volunteers that age. Methods. Consecutive PsA participated this cross-sectional study, irrespective enthesitis complaints collected data about complaints, physical activity avoidance, medication, enthesitis....

Objective: This paper describes the baseline demographics, clinical characteristics, and patient-reported outcomes (PROs) according to phenotype of patients with early psoriatic arthritis (PsA) for purpose creating a decision support system daily practice.Method: Patients newly diagnosed PsA were included in Dutch south west Early Psoriatic ARthritis (DEPAR) study. No classification criteria applied, ensure collection real-world data on medication, PROs. An IT infrastructure facilitated...