A5043494558- Plant Molecular Biology Research
- Plant Reproductive Biology
- Plant nutrient uptake and metabolism
- Light effects on plants
- Plant Stress Responses and Tolerance
- Plant-Microbe Interactions and Immunity
- Phytoplasmas and Hemiptera pathogens
- Photoreceptor and optogenetics research
- Leaf Properties and Growth Measurement
- Plant tissue culture and regeneration
- Photosynthetic Processes and Mechanisms
- Polysaccharides and Plant Cell Walls
- Connexins and lens biology
- Phytochemical compounds biological activities
- Muscle and Compartmental Disorders
- Antimicrobial Peptides and Activities
- Liver Disease Diagnosis and Treatment
- Aluminum toxicity and tolerance in plants and animals
- Redox biology and oxidative stress
- Weed Control and Herbicide Applications
- Dialysis and Renal Disease Management
- Cardiovascular Disease and Adiposity
- Autophagy in Disease and Therapy
- Transgenic Plants and Applications
- Allelopathy and phytotoxic interactions
Consejo Superior de Investigaciones Científicas
2012-2025
Universidad Cardenal Herrera CEU
2024-2025
Instituto de Biología Molecular y Celular de Plantas
2012-2025
Universitat Politècnica de València
2012-2025
Instituto de Agroquímica y Tecnología de Alimentos
2022-2024
Instituto Valenciano de Investigaciones Agrarias
2024
University of Padua
2009-2014
Plant development is modulated by the convergence of multiple environmental and endogenous signals, mechanisms that allow integration different signaling pathways currently being unveiled. A paradigmatic case concurrence brassinosteroid (BR) gibberellin (GA) in control cell expansion during photomorphogenesis, which supported physiological observations several plants but for no molecular mechanism has been proposed. In this work, we show these two occurs through physical interaction between...
The ability of plants to provide a plastic response environmental cues relies on the connectivity between signaling pathways. DELLA proteins act as hubs that relay information multiple transcriptional circuits control growth and development through physical interaction with transcription factors from different families. We have analyzed presence one protein at Arabidopsis genome by chromatin immunoprecipitation coupled large-scale sequencing we find it binds promoters genes. Enrichment...
Significance DELLA proteins are plant-specific transcriptional regulators that act as signaling hubs at the interface between environment and networks control growth. The growth-promoting hormone gibberellin destabilizes DELLAs. Here we describe an alternative pathway to destabilize these proteins. We show DELLAs substrate of COP1, E3 ubiquitin ligase increases its activity promote growth in response shade or warmth. Our results not changes levels, mediates rapid destabilization environmental cues.
In response to canopy shade, plant vegetative structures elongate gain access light. However, the mechanism that allows a plastic transcriptional shade light is not fully elucidated. Here we propose activity of PIF4, key transcription factor in signalling network, modulated by interplay between BBX24 regulator and DELLA proteins, which are negative regulators gibberellin (GA) pathway. We show GA-related targets enriched among genes responsive under shade-response defect bbx24 mutants rescued...
Stomata govern the gaseous exchange between leaf and external atmosphere, their function is essential for photosynthesis global carbon oxygen cycles. Rhythmic stomata movements in daily dark/light cycles prevent water loss at night allow CO2 uptake during day. How actors involved are transcriptionally regulated how this might contribute to rhythmicity largely unknown. Here, we show that morning opening depends on previous period. The transcription factors PHYTOCHROME-INTERACTING FACTORS...
Potassium (K+) is a key monovalent cation necessary for multiple aspects of cell growth and survival. In plants, this also plays role in the control stomatal movement. KAT1 its homolog KAT2 are main inward rectifying channels present guard cells, mediating K+ influx into these resulting opening. To gain further insight regulation channels, we performed split-ubiquitin protein-protein interaction screen searching interactors Arabidopsis (Arabidopsis thaliana). We characterized one candidates,...
Fungal infections threaten human health worldwide and have a negative impact on food security, damaging crop production causing animal diseases. At present, only few classes of fungicides are available due to the complexity targeting fungi without affecting plant, animal, or hosts.
Aims/Purpose: Connexins (Cxs) are a family of structurally‐related transmembrane proteins that form gap junction channels. These channels essential for direct intercellular communication in many tissues. Cxs play crucial role retina homeostasis and visual information processing. connect photoreceptors, horizontal cells, bipolar amacrine cells ganglion the mammalian retina. They proposed as therapeutic targets several retinal diseases. Although aging is considered risk factor different...
Chronic kidney disease (CKD) patients show high rates of cardiovascular (CVD) and mortality. In the general population, obesity, hypertension, diabetes are known as classical CVD risk factors. However, CKD have other predisposing factors more associated with bone mineral metabolism disorders (BMD). BMD originates from reduced 1,25-dihydroxy vitamin D hypocalcemia, which lead to secondary hyperparathyroidism, increased parathyroid hormone (PTH) levels hyperphosphatemia progression renal...
In plants, inward rectifying potassium channels regulate entry into guard cells and are a key factor controlling stomatal opening. KAT1 is major channel present in Arabidopsis thaliana cell membranes. The identification of regulators like promising approach for the development strategies to improve plant drought tolerance. Using high-throughput Split-ubiquitin screening yeast, we identified RPT2 (ROOT PHOTOTROPISM 2) as interactor. Here, results characterization this interaction yeast...
The polyploid weed Schoenoplectus mucronatus (L.) Palla has evolved target-site resistance to ALS-inhibiting herbicides in Italian rice crops. Molecular and genetic characterisation of the mechanism is relevant evolution management herbicide resistance. authors aimed (a) study organisation loci two field-selected S. populations with different cross-resistance patterns, (b) identify mutations endowing ALS inhibitors determine role these by using transgenesis (c) analyse implications for...
Summary Fungal antifungal proteins (AFPs) have attracted attention as novel biofungicides. Their exploitation requires safe and cost‐effective producing biofactories. Previously, Penicillium chrysogenum digitatum produced recombinant AFPs with the use of a P. ‐based expression system that consisted paf gene promoter, signal peptide (SP)‐pro sequence terminator. Here, regulatory elements afpA encoding highly PeAfpA from expansum were developed an for AFP production through FungalBraid...
Antifungal proteins (AFPs) from filamentous fungi offer the potential to control fungal infections that threaten human health and food safety. AFPs exhibit broad antifungal spectra against harmful fungi, but limited knowledge of their killing mechanism hinders applicability. PeAfpA Penicillium expansum shows strong potency plant pathogens stands above other for being active yeast Saccharomyces cerevisiae. We took advantage this used a model laboratory strain S. cerevisiae gain insight into...
In Arabidopsis thaliana, the ability to flower is mainly related a floral repressor, FLOWERING LOCUS C (FLC), which regulated through vernalization pathway. The genes controlling pathway seem be only partially conserved in dicots other than Brassicaceae. Cichorium intybus (chicory) biennial species belonging Asteraceae family, and it shows an obligate requirement for flowering. MADS (MCM1, Agamous, Deficiens, SRF) FLC-like (CiMFL) sequences were isolated C. by RT-PCR their expression...
Due to anthropogenic global warming, droughts are expected increase and water availability decrease in the coming decades. For this reason, research is increasingly focused on developing plant varieties crop cultivars with reduced consumption. Transpiration occurs through stomatal pores, resulting loss. Potassium plays a significant role regulation. KAT1 an inward-rectifying potassium channel that contributes opening. Using yeast high-throughput screening of Arabidopsis cDNA library, MEE31...
Abstract Citrus Huanglongbing (HLB) disease, also known as “citrus greening”, is currently considered the most devastating citrus disease due to its rapid spread, and high severity. Presently, research efforts are focused on searching for either curative treatments or resistant cultivars combat HLB-associated bacterium ‘ Candidatus Liberibacter asiaticus’ ( C Las). Metabolomics can help unravel mechanisms supporting potential tolerance/resistance of relatives. Herein, we carried out a...
Abstract Stomata govern the gaseous exchange between leaf and external atmosphere, their function is essential for photosynthesis global carbon oxygen cycles. Rhythmic stomata movements in daily dark/light cycles prevent water loss at night allow CO 2 uptake during day. How actors involved are transcriptionally regulated how this might contribute to rhythmicity largely unknown. Here, we show that morning opening depends on previous period. The transcription factors PHYTOCHROMEINTERACTING...
Abstract Citrus Huanglongbing (HLB) disease, also known as “citrus greening”, is currently considered the most devastating citrus disease due to its rapid spread, and high severity. Presently, research efforts are focused on searching for either curative treatments or resistant cultivars combat HLB-associated bacterium ‘ Candidatus Liberibacter asiaticus’ ( C Las). Metabolomics can help unravel mechanisms supporting potential tolerance/resistance of relatives. Herein, we carried out a...
Abstract Background and Aims Patients with CKD show high cardiovascular complication rates. There are classical risk factors, such as obesity, dyslipidemia, diabetes; however, other disease factors associated mineral metabolism disorders (phosphorus, hyperparathyroidism, etc.) typically appear in CKD. Due to their pleiotropic effects, vitamin D analogs, cholecalciferol, calcitriol, or paricalcitol, have proven effective controlling bone secondary pathologies. On the hand, visceral adiposity...