A5056762171- Ubiquitin and proteasome pathways
- 14-3-3 protein interactions
- Microbial Natural Products and Biosynthesis
- Microtubule and mitosis dynamics
- Competitive and Knowledge Intelligence
- Renal and related cancers
- Genetic diversity and population structure
- Genetic Mapping and Diversity in Plants and Animals
- Landslides and related hazards
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Chromosomal and Genetic Variations
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
University of Leicester
2020-2024
Institute for Research in Biomedicine
2023
University of Otago
2021
University of Kent
2016
Mouse Double Minute 2 (MDM2) is a key negative regulator of the tumour suppressor protein p53. MDM2 overexpression occurs in many types cancer and results suppression wild type The 14-3-3 family adaptor proteins are known to bind 14-3-3σ isoform controls cellular localisation stability inhibit its activity. Therefore, small molecule stabilisation 14-3-3σ/MDM2 protein-protein interaction (PPI) potential therapeutic strategy for treatment cancer. Here, we provide detailed biophysical...
14-3-3 proteins are an important family of hub that play roles in many cellular processes via a large network interactions with partner proteins. Many these protein-protein (PPI) implicated human diseases such as cancer and neurodegeneration. The stabilisation selected PPIs using drug-like 'molecular glues' is novel therapeutic strategy high potential. However, the examples reported to date have number drawbacks terms selectivity potency. Here, we report WR-1065, active species approved drug...
Abstract Mouse Double Minute 2 (MDM2) is a key negative regulator of the tumour suppressor protein p53. MDM2 overexpression occurs in many types cancer and results suppression wild type The 14-3-3 family adaptor proteins are known to bind 14-3-3σ isoform controls cellular localisation stability inhibit its activity. Therefore, small molecule stabilisation 14-3-3σ/MDM2 protein-protein interaction (PPI) potential therapeutic strategy for treatment cancer. In this work we provide detailed...
Colorectal cancer is primarily a disease of the developed world. The incidence rate has continued to increase over time, reflecting both demographic and lifestyle changes, which have resulted in genomic epigenomic modifications. Many epigenetic modifications occur genes known be closely associated with embryonic development cellular growth. In particular, paired box (PAX) transcription factors are crucial for correct tissue during embryogenesis due their role regulating involved...