A5042178795- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- HIV-related health complications and treatments
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- Hepatocellular Carcinoma Treatment and Prognosis
- SARS-CoV-2 and COVID-19 Research
- Liver Disease and Transplantation
- Respiratory viral infections research
- Biochemical and Molecular Research
- Hepatitis Viruses Studies and Epidemiology
- Inflammatory Biomarkers in Disease Prognosis
- Bacillus and Francisella bacterial research
- Cannabis and Cannabinoid Research
- Antibiotic Use and Resistance
- Poxvirus research and outbreaks
- Bayesian Methods and Mixture Models
- Thermal Regulation in Medicine
- Viral-associated cancers and disorders
- Central Venous Catheters and Hemodialysis
- Statistical Methods and Bayesian Inference
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2016-2025
Vita-Salute San Raffaele University
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
San Raffaele University of Rome
2023
IRCCS Ospedale San Raffaele
2013-2022
University of Campania "Luigi Vanvitelli"
2016
University of Naples Federico II
2016
Massachusetts Department of Mental Health
2016
Background Dermatophytosis is an infection of the skin or adnexa, which extremely widespread in environment. Sexually transmitted infections (STIs) are increasing global public health threat, especially among men who have sex with (MSM). This study aims to describe outbreak sexually dermatophytosis MSM our cohort between April 2022 and October 2023. Methods a retrospective monocentric including outpatients were diagnosed at least one episode March 2010 2023 Infectious Diseases Unit San...
Abstract The aim of this study was to evaluate the impact early treatment with corticosteroids on SARS-CoV-2 clearance in hospitalized COVID-19 patients. Retrospective analysis patients admitted San Raffaele Hospital (Milan, Italy) moderate/severe and availability at least two nasopharyngeal swabs. primary outcome time swab negativization. A multivariable Cox model fitted determine factors associated Of 280 included, 59 (21.1%) were treated steroids. Differences observed between steroid...
In this observational cohort study, the objective was to compare low-density lipoprotein (LDL) cholesterol dynamics in people with HIV (PWH) who switched a regimen containing doravirine (DOR), rilpivirine, dolutegravir, or bictegravir and were naïve studied drugs. Generalized additive mixed models used examine LDL dynamics. measured 2381 PWH: during first two years, DOR had greatest lowering effect showed most favorable lipid outcome.
Objective: Sexually transmitted infections (STIs) are associated with an increased risk of HIV transmission, raising concerns in case virus resistant (R) to the drugs currently approved for pre-exposure prophylaxis (PrEP). We explored incidence STIs men who have sex (MSMWH) and resistance tenofovir/emtricitabine (TXF/FTC) and/or cabotegravir (CAB). Design: Retrospective, cohort study on MSMWH antiretroviral treatment (ART) ≥1 genotyping test (GRT) including integrase. Methods: The following...
Ribavirin is an inosine monophosphate dehydrogenase inhibitor with demonstrated activity against coronaviruses, including SARS-CoV-2. Five hospitalized patients COVID-19 (confirmed by positive tests for SARS-CoV-2) received treatment ribavirin inhalation solution (ribavirin aerosol) as part of a compassionate use program. Patients included four men and one woman, age range 29-72 years. were managed according to international Italian guidelines COVID-19. In addition, therapy aerosol 100 mg/mL...
Background: Aims of this study are assessing prevalence anal human papillomavirus (HPV) genotypes in male who have sex with men (MSM) living HIV over a period 5 years and determining risk factors for infection from high-risk (HR) HPV or included vaccine Gardasil 9. Setting: Time–trend, monocentric on MSM underwent test at site 2015 to 2019. Methods: Anal swabs were processed by multiplex real-time polymerase chain reaction detect genotypes. The Cochran–Armitage was used assess linear trend...
Little is known about the frequency or geographic distributions of naturally occurring resistance-associated substitutions (RASs) in nonstructural protein 5A (NS5A) domain hepatitis-C virus (HCV) genotype-3 (GT-3) different subtypes. We investigated GT-3 RASs that confer resistance to NS5A inhibitors.From a publicly accessible database, we retrieved 58 complete genomes and an additional 731 worldwide sequences from patients infected with were naive direct-acting antiviral treatment.We...
Abstract Objective To describe the trajectories of homeostatic model assessment for insulin resistance (HOMA‐IR) index in a cohort HIV‐1 infected patients during their first‐line antiretroviral (ART) regimen. Methods Retrospective analysis naïve who started ART from 2007 at Infectious Diseases Unit San Raffaele Hospital, Milan. We included treated with two nucleoside reverse transcriptase inhibitors (NRTIs, tenofovir, abacavir, lamivudine or emtricitabine), and one anchor drug...
Hepatocellular carcinoma (HCC) is increasingly prevalent in people living with HIV. Systemic inflammation a prognostic factor requiring validation HIV-associated HCC.Using multi-centre database of consecutive HCC cases, we investigated the role panel inflammatory markers, including neutrophil to lymphocyte ratio (NLR), using univariate and multivariate survival analyses.Fifty-nine patients secondary hepatitis C (69%) or B virus infection (32%) were identified. The median was 22 months. A...
HIV-monoinfected patients are susceptible to liver injury by different factors and may develop fibrosis, which requires adequate clinical management in terms of therapy disease monitoring. We aimed evaluate the presence fibrosis identified transient elastography (TE), its relationships with indirect biochemical markers [the aspartate aminotransferase/platelet ratio index (APRI), Forns FIB-4] predictive receiving antiretroviral (ART).Seventy-two underwent TE were evaluated using APRI, FIB-4....
The extent of mixed hepatitis C virus (HCV) genotype in different compartments (plasma and peripheral blood mononuclear cell, PBMC) possible association with treatment efficacy HIV/HCV coinfected patients remains to be unknown. objective this study was elucidate the frequency infection (MG), its profile during anti-HCV treatment, influence genotypes on response rate. compartmentalization HCV population investigated by next-generation sequencing 19 under peginterferon/ribavirin (P–R). Ten...
This is the first study to analyze impact of rs35761398 variant CNR2 gene leading substitution GLN (Q) codon 63 cannabinoid receptor 2 (CB2) with ARG (R) on clinical presentation chronic hepatitis in HIV/HCV coinfected patients.Enrolled this were 166 consecutive patients, naïve for HCV treatment. A pathologist unaware patients' condition graded liver fibrosis, necroinflammation (Ishak) and steatosis. All patients screened CB2 polymorphism.Of 72.9% males, 42.5% infected HCV-genotype-3 60.2%...
Human immunodeficiency virus-1 (HIV-1) is characterised by a vast genetic diversity classified into distinct phylogenetic strains and recombinant forms. We describe the HIV-1 molecular epidemiology evolution of 129 consecutive positive migrants living in Milan (northern Italy). Polymerase gene sequences 116 subtype-B patients were aligned with reference (https://www.ncbi.nlm.nih.gov/) using MAFFT alignment edited Bioedit software. A maximum likelihood (ML) tree was performed MEGA7 visualised...
AIMTo evaluate the impact of Glu167Lys (E167K) transmembrane 6 superfamily member 2 (TM6SF2) variant on biochemical and morphologic expression liver lesions in human immunodeficiency virus (HIV)/ hepatitis C (HCV) co-infected patients. METHODSThe study comprised 167 consecutive patients with HIV/ HCV coinfection biopsy-proven chronic hepatitis.A pathologist graded fibrosis necroinflammation
Menopause is a high-risk period for osteoporosis, which may be exacerbated by HIV and/or antiretroviral therapy (ART). Our goal was to study the impact of switching from tenofovir disoproxil fumarate (TDF) alafenamide (TAF) on bone mineral density (BMD) in peri- and early postmenopausal women living with HIV. This randomized international multicenter an versus delayed (48-week) switch. BMD measured dual energy X-ray absorptiometry scan. Thirty-four were enrolled: 19 immediate 15 switch arm...
To evaluate the plasma trough concentrations ( C ) of dolutegravir and rilpivirine used in combination with simeprevir sofosbuvir HIV/hepatitis virus (HCV)-coinfected patients liver cirrhosis. Virological efficacy safety both ART anti-HCV therapy were assessed.A prospective observational study HIV/HCV-coinfected cirrhosis on plus treated (±ribavirin) was conducted. Dolutegravir, rilpivirine, GS-331007 (sofosbuvir metabolite) evaluated a validated HPLC method at treatment baseline weeks 2 4....