A5100415476- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Biosensors and Analytical Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Photocatalysis Techniques
- Plasmonic and Surface Plasmon Research
- DNA and Nucleic Acid Chemistry
- Advanced Computational Techniques and Applications
- DNA and Biological Computing
- Advanced Biosensing Techniques and Applications
- Adsorption and biosorption for pollutant removal
- Gas Sensing Nanomaterials and Sensors
- Image and Signal Denoising Methods
- Bacteriophages and microbial interactions
- Polymer-Based Agricultural Enhancements
- Modular Robots and Swarm Intelligence
- Graphene and Nanomaterials Applications
- Environmental remediation with nanomaterials
- Molecular Junctions and Nanostructures
- Water Quality Monitoring and Analysis
- Nanomaterials for catalytic reactions
- Advanced Nanomaterials in Catalysis
- Electrochemical sensors and biosensors
- Thin-Film Transistor Technologies
- Arsenic contamination and mitigation
Donghua University
2022-2025
Nanjing University
2024
Nanjing Agricultural University
2024
The Wallace H. Coulter Department of Biomedical Engineering
2020-2024
Georgia Institute of Technology
2020-2024
Suzhou University of Science and Technology
2023-2024
University of Science and Technology of China
2016-2024
BOE Technology Group (China)
2019-2024
Fujian Normal University
2023
Shanghai Jiao Tong University
2014-2022
Uniform silver-containing metal nanostructures with strong and stable surface-enhanced Raman scattering (SERS) signals hold great promise for developing ultrasensitive probes biodetection. Nevertheless, the direct synthesis of such ready-to-use nanoprobes remains extremely challenging. Herein we report a DNA-mediated gold–silver nanomushroom interior nanogaps directly synthesized used multiplex simultaneous SERS detection various DNA RNA targets. The involved in can act as not only gap...
We have developed a surface-enhanced Raman scattering (SERS)-active substrate based on gold nanoparticle-decorated chemical vapor deposition (CVD)-growth graphene and used it for multiplexing detection of DNA. Due to the combination nanoparticles graphene, signals dye were dramatically enhanced by this novel substrate. With nanoparticles, DNA capture probes could be easily assembled surface films which drawback directly immobilize This platform exhibits extraordinarily high sensitivity...
Molecular computing holds great promise for diagnosis and treatment of diseases at the molecular level; nevertheless, designing logic gates to operate programmably autonomously diagnostics still remains challenging. We designed on DNA Origami microRNA analysis. As a demonstration, two indicators heart failure, microRNA-21 microRNA-195, were selected as inputs. The contain main modules: computation module output module, performing in single nanostructure. recognizes disease indicators, while...
Microarrays of biomolecules have greatly promoted the development fields genomics, proteomics, and clinical assays because their remarkably parallel high-throughput assay capability. Immobilization strategies for on a solid support surface play crucial role in fabrication high-performance biological microarrays. In this study, rationally designed DNA tetrahedra carrying three amino groups one single-stranded extension were synthesized by self-assembly four oligonucleotides, followed liquid...
Surface-enhanced Raman scattering (SERS) has recently been used to design novel nanoprobes called "SERS tags" which hold great promise for the fields of biosensing and nanomedicine. More recent advances have shed new light on synthesis uniform nanostructures with interior nanogaps stable SERS enhancement. However, producing nanogap-based nanotags directly controllably strong multiplex signals as well developing a analytical platform recognize different types bioactive molecules still remain...
Sensing nucleic acids typically involves the recognition of a specific sequence and reporting by, for example, fluorogenic reaction yielding one activated dye molecule per detected acid. Here, we show that after binding to DNA origami track bound target (a "DNA walker") can release fluorescence many molecules by acting as catalyst an enzymatic nicking reaction. As walking kinetics sensitively depends on walker sequence, resulting brightness distribution origamis is fingerprint with...
DNA nanostructures with programmable nanoscale patterns has been achieved in the past decades, and molecular information coding (MIC) on those designed gained increasing attention for security. However, achieving steganography cryptography synchronously remains a challenge. Herein, we demonstrated MIC reconfigurable origami domino array (DODA), which can reconfigure intrinsic but keep DODA outline same steganography. When set of keys (DNA strands) are added, cryptographic data be translated...
Although "hot spots" have been proved to contribute surface enhanced Raman scattering (SERS), less attention was paid increase the number of spot" directly enhance signals in bioanalytical systems. Here we report a new strategy based on nano rolling-circle amplification (nanoRCA) and hyperbranched (nanoHRCA) groups for protein microarrays. First, ssDNA are coassembled gold nanoparticles, making assembled probe both binding ability hybridization ability. Second, ssDNAs act as primers initiate...
Molecular patterns with nanoscale precision have been used to mimic complex molecular networks. One key challenge in is perform active pattern operations controllable systems fully imitate their dynamic behaviors. Here, we present a reconfigurable DNA origami domino array-based operation (DODA DPO) system proximity-induced control for operations. The activatable platform of DODA endows spontaneous cascade stacking conformational transformation from the "before" "after" conformation by set...
Dynamic DNA origami has been employed for generating a rich repository of molecular nanomachines that are capable sensing various cues and changing their conformations accordingly. The common design principle the existing is each dynamic programmed to transform in specific manner, nanomachine needs be redesigned achieve different form transformation. However, it remains challenging enable multitude controlled transformations single nanomachine. Here we report modular method programmatically...
We herein report a power-free microfluidic chip for fluorescent DNA detection with high single-nucleotide polymorphism discrimination, using intercalator and graphene oxide.
There are still challenges for the development of multifunctional carbon nanotubes (CNTs). Here, a multiwalled nanotube (MWCNT)-based rolling circle amplification system (CRCAS) is reported which allows in situ replication DNA primer on surface MWCNTs to create long single-strand (ssDNA) where large number nanoparticles or proteins could be loaded, forming nano-biohybridized 3D structure with powerful signal ability. In this strategy, binding ability proteins, hybridization, DNA, and...
Iron deficiency is a worldwide problem in modern agriculture, which causes leaf chlorosis and severe declines crop yield. Therefore, improving the utilization efficiency (UE) of ferrous fertilizer an urgent need. This study developed pH-controlled-release foliar (PCRFFF) composed sulfate (FeSO4·7H2O), microcrystalline cellulose (MC), attapulgite (ATP). Therein, MC was oxidized to form carboxyl (CC) that possessed plenty groups (-COOH) on surface could effectively chelate Fe2+ [Fe(II)]...