A5068786760- Advanced MRI Techniques and Applications
- Cardiac Arrest and Resuscitation
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neural dynamics and brain function
- Pain Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Lipid Membrane Structure and Behavior
- Epilepsy research and treatment
- Forensic Toxicology and Drug Analysis
- Radiation Dose and Imaging
- Ultrasound in Clinical Applications
- Poisoning and overdose treatments
- RNA and protein synthesis mechanisms
- Venomous Animal Envenomation and Studies
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Rabies epidemiology and control
- Respiratory Support and Mechanisms
- Emergency and Acute Care Studies
- Protein Structure and Dynamics
- Healthcare Policy and Management
- Pharmacological Effects and Toxicity Studies
- Radiology practices and education
University of North Dakota
2024-2025
University of Pennsylvania
2020-2025
Louisiana State University Health Sciences Center Shreveport
2011-2024
California University of Pennsylvania
2024
University of Pennsylvania Health System
2020
Florida State University
2019-2020
Penn Center for AIDS Research
2020
Boehringer Ingelheim (Germany)
2008-2017
Max Planck Institute for Developmental Biology
2006-2017
Louisiana State University Health Sciences Center New Orleans
2001-2016
Accumulation of tau pathology in Alzheimer disease (AD) correlates with cognitive decline. Anti-tau immunotherapies were proposed as potential interventions AD. While antibodies targeting N-terminal failed to demonstrate clinical efficacy prodromal-to-mild AD, their utility at other stages was not evaluated prior studies. Lauriet is a phase 2 study an anti-tau monoclonal antibody, semorinemab, patients mild-to-moderate
Background. Crotalidae Polyvalent Immune Fab (Ovine) has been the only antivenom commercially available in US since 2007 for treatment of Crotalinae envenomation. Late coagulopathy can occur or recur after clearance antivenom, often hospital discharge, lasting some cases more than 2 weeks. There have serious, even fatal, bleeding complications associated with recurrence phenomena. Frequent follow-up is required, and additional intervention hospitalization necessary. F(ab')2 immunoglobulin...
Extraction of membrane proteins from biological membranes is usually accomplished with the help detergents. This unit describes use detergents to solubilize and purify proteins. The chemical physical properties different classes typically used samples are discussed. A separate section addresses compatibility applications downstream protein purification process, such as optical spectroscopy, mass spectrometry, crystallography, or biomolecular NMR. Protocols in this include isolation...
Dermcidin encodes the anionic amphiphilic peptide DCD-1L, which displays a broad spectrum of antimicrobial activity under conditions resembling those in human sweat. Here, we have investigated its mode activity. We found that DCD-1L interacts preferentially with negatively charged bacterial phospholipids helix axis is aligned flat on lipid bilayer surface. Upon interaction bilayers forms oligomeric complexes are stabilized by Zn2+. able to form ion channels membrane, and propose Zn2+-induced...
Medical Education 2011: 45: 347–353 Context Teaching 12-lead electrocardiogram (ECG) interpretation to students and residents is a challenge for medical educators. To date, few studies have compared the effectiveness of different techniques used ECG teaching. Objectives This study aimed determine if common teaching techniques, such as those involving workshops, lectures self-directed learning (SDL), increase students' ability correctly interpret ECGs. It also compare these formats. Methods...
Abstract Planning surgery for patients with medically refractory epilepsy often requires recording seizures using intracranial EEG. Quantitative measures derived from interictal EEG yield potentially appealing biomarkers to guide these surgical procedures; however, their utility is limited by the sparsity of electrode implantation as well normal confounds spatiotemporally varying neural activity and connectivity. We propose that comparing recordings a normative atlas connectivity can...
Magnetic resonance imaging (MRI) is a fundamental tool in the diagnosis and management of neurological diseases such as multiple sclerosis (MS). New portable, low-field strength, MRI scanners could potentially lower financial technical barriers to neuroimaging reach underserved or disabled populations, but sensitivity these devices for MS lesions unknown. We sought determine if white matter can be detected on portable 64mT scanner, compare automated lesion segmentations total volume between...
Brain maps, or atlases, are essential tools for studying brain function and organization. The abundance of available atlases used across the neuroscience literature, however, creates an implicit challenge that may alter hypotheses predictions we make about neurological pathophysiology. Here, demonstrate how parcellation scale, shape, anatomical coverage, other atlas features impact our prediction brain's from its underlying structure. We show network topology, structure-function correlation...
Portable low-field-strength magnetic resonance imaging (MRI) systems represent a promising alternative to traditional high-field-strength with the potential make MR technology available at scale in low-resource settings. However, lower image quality and resolution may limit research clinical of these devices. We tested two super-resolution methods enhance low-field system compared their correspondence images acquired from high-field sample young people.
Abstract Extraction of membrane proteins from biological membranes is usually accomplished with the help detergents. This unit describes use detergents to solubilize and purify proteins. The chemical physical properties different classes typically used samples are discussed. A separate section addresses compatibility applications downstream protein purification process, such as optical spectroscopy, mass spectrometry, crystallography, biomolecular NMR, or electron microscopy. brief summary...
Chronic opioid therapy for non-malignant pain conditions has significantly increased over the last 15 years. Recently, correlation between analgesics and alternations in brain structure, such as leukoencephalopathy, axon demyelination, white matter lesions, been demonstrated patients with a history of long-term use prescription opioids. The exact mechanisms underlying neurotoxic effect opioids on central nervous system are still not fully understood. We investigated chronic using an animal...
Omp85 proteins are essential located in the bacterial outer membrane. They involved membrane biogenesis and assist protein insertion folding by an unknown mechanism. Homologous exist eukaryotes, where they mediate assembly organelles of endosymbiotic origin, mitochondria chloroplasts. We set out to explore homologous relationship between cyanobacteria chloroplasts, studying from thermophilic cyanobacterium Thermosynechococcus elongatus. Using state-of-the art sequence analysis clustering...
Abstract The olfactory system is uniquely heterogeneous, performing multifaceted functions (beyond basic sensory processing) across diverse, widely distributed neural substrates. While knowledge of human olfaction continues to grow, it remains unclear how the network organized serve this unique set functions. Leveraging a large and high-quality resting-state functional magnetic resonance imaging (rs-fMRI) dataset nearly 900 participants from Human Connectome Project (HCP), we identified...
Abstract Brain network models derived from graph theory have the potential to guide functional neurosurgery, and improve rates of post-operative seizure freedom for patients with epilepsy. A barrier applying these clinically is that intracranial EEG electrode implantation strategies vary by centre, region country, cortical grid & strip electrodes (Electrocorticography), purely stereotactic depth (Stereo EEG), a mixture both. To determine whether one type study are broadly applicable...
Introduction Snakebite envenoming (SBE) results in over 500 000 deaths or disabling injuries annually. Varespladib methyl, an oral inhibitor of secretory phospholipase A2, is a nearly ubiquitous component snake venoms. We conducted phase II clinical trial to assess efficacy and safety varespladib methyl patients bitten by venomous snakes. Methods This double-blind, randomised, placebo-controlled enrolled emergency departments India the USA. Patients with SBE were randomly assigned (1:1)...
Background: This study investigates the correlation between maternal mortality rates and socioeconomic factors, particularly education level race in a rural state. Lower educational attainment often correlates with reduced status healthcare access, potentially contributing to escalating rates, especially among Native American communities. North Dakota’s demographic composition, significant Caucasian populations, offers insights into persistent disparities healthcare. Systemic challenges,...
Background: In 2021 there were 1205 maternal deaths in the United States, translating to a mortality rate of 32.9 per 100,000 live births. The National Vital Statistics System reports this was nearly double 17.4 death 2018. With 754 2019 and 861 2020, it not until 2022 that unexplainably dropped 817. Healthy Woman 2000 Goal projected steep decline deaths, yet two decades later at an all-time high. These rates do capture 50,000+ women who face life-endangering pregnancy complications or “near...
LowGAN, a generative model trained on paired high-resolution 3-T and lower-resolution portable 64-mT MRI data, improved low-field-strength image quality brain morphometry white matter lesion conspicuity in multiple sclerosis.