A5025877682- Polymer Surface Interaction Studies
- Nanoplatforms for cancer theranostics
- Advanced Photocatalysis Techniques
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Proteins in Food Systems
- Luminescence and Fluorescent Materials
- Nanomaterials for catalytic reactions
- Surfactants and Colloidal Systems
- Advanced biosensing and bioanalysis techniques
- Hydrogels: synthesis, properties, applications
- Advanced Nanomaterials in Catalysis
- Salmonella and Campylobacter epidemiology
- Graphene and Nanomaterials Applications
- Advanced Polymer Synthesis and Characterization
- Carbon dioxide utilization in catalysis
- Molecular Sensors and Ion Detection
- Pickering emulsions and particle stabilization
- Environmental remediation with nanomaterials
- Semiconductor materials and devices
- Conducting polymers and applications
- Perovskite Materials and Applications
- Adsorption and biosorption for pollutant removal
- Protein Interaction Studies and Fluorescence Analysis
- Copper-based nanomaterials and applications
State Key Laboratory of Chemical Engineering
2016-2025
East China University of Science and Technology
2016-2025
Ministry of Education
2025
Nanjing Forestry University
2025
Institute of Chemical Engineering
2025
Chinese Research Academy of Environmental Sciences
2024
Waters (China)
2024
Xinjiang Production and Construction Corps
2018-2023
Shihezi University
2015-2023
Foshan University
2021-2023
A type III protein secretion system encoded by Salmonella pathogenicity island 2 (SPI2) has been found to be required for virulence and survival within macrophages. Here, SPI2 was shown allow typhimurium avoid NADPH oxidase–dependent killing The ability of SPI2-mutant bacteria survive in macrophages cause lethal infection mice restored abrogation the respiratory burst. Ultrastructural immunofluorescence microscopy demonstrated efficient localization oxidase proximity vacuoles containing but...
Development of "smart" noninvasive bioimaging probes for trapping specific enzyme activities is highly desirable cancer therapy in vivo. Given that β-galactosidase (β-gal) an important biomarker cell senescence and primary ovarian cancers, we design enzyme-activatable ratiometric near-infrared (NIR) probe (DCM-βgal) the real-time fluorescent quantification β-gal activity vivo situ. DCM-βgal manifests significantly turn-on NIR signals simultaneously response to concentration, which makes it...
The roles of the NADPH phagocyte oxidase (phox) and inducible nitric oxide synthase (iNOS) in host resistance to virulent Salmonella typhimurium were investigated gp91phox−/−, iNOS−/−, congenic wild-type mice. Although both gp91phox−/− iNOS−/− mice demonstrated increased susceptibility infection with S. compared mice, kinetics bacterial replication dramatically different mouse strains. Greater numbers present spleens livers C57BL/6 controls as early day 1 infection, all succumbed within 5 d....
Superoxide dismutase (SOD) catalyzes the conversion of superoxide radical to hydrogen peroxide. Periplasmic localization bacterial Cu,Zn-SOD has suggested a role this enzyme in defense against extracellular phagocyte-derived reactive oxygen species. Sequence analysis regions flanking Salmonella typhimurium sodC gene encoding demonstrates significant homology λ phage proteins, reflecting possible bacteriophage-mediated horizontal transfer determinant among pathogenic bacteria. deficient...
The interactions of proteins and polyelectrolytes lead to diverse applications in separations, delivery wound repair, are thus interest scientists e.g. (a) glycobiology, (b) tissue engineering, (c) biosensing, (d) pharmacology. This breadth is accompanied by an assortment contexts models which seen as protein cognates assisting complex cellular roles, surrogates for the extracellular matrix, mimicking its hydration, mechanical sequestering properties, benign hosts that gently entrap, deposit...
Underwater adhesion is crucial to many marine life forms living a sedentary lifestyle. Amongst them, mussel has been mostly studied, which inspires numerous investigations of 3,4-dihydroxyphenylalanine (DOPA)-based organic adhesives. In contrast, reef-building oysters represent another important "inorganic" strategy molluscs for by generating biomineralized organic–inorganic adhesives, still rarely studied and no synthetic analogues have ever reported so far. Here, novel type oyster-inspired...
Pesticides are widely used to increase agricultural productivity, however, weak adhesion and deposition lead low efficient utilization. Herein, we prepare a nanopesticide formulation (tebuconazole nanopesticides) which is leaf-adhesive, water-dispersed via rapid nanoparticle precipitation method, flash nanoprecipitation, using temperature-responsive copolymers poly-(2-(dimethylamino)ethylmethylacrylate)-b-poly(ε-caprolactone) as the carrier. Compared with commercial suspensions,...
Paradoxically, nitric oxide (NO) has been found to exhibit cytotoxic, antiproliferative, or cytoprotective activity under different conditions. We have utilized Salmonella mutants deficient in antioxidant defenses peptide transport gain insights into NO actions. Comparison of three donor compounds reveals distinct and independent cellular responses associated with specific redox forms NO. The peroxynitrite (OONO-) generator 3-morpholinosydnonimine hydrochloride mediates oxygen-dependent...
Periplasmic Cu, Zn-cofactored superoxide dismutase (SodC) protects Gram-negative bacteria from exogenous oxidative damage. The virulent Salmonella typhimurium strain ATCC 14028s has been found to contain two discrete periplasmic Zn-SOD enzymes that are only 57% identical at the amino acid level. SodCI is carried by a cryptic bacteriophage, and SodCII closely related Zn-superoxide of Escherichia coli . All serotypes appear carry sodCII locus, but phage-associated sodCI gene in certain strains...
The effect of polyelectrolyte binding affinity on selective coacervation proteins with the cationic polyelectrolyte, poly(diallyldimethylammonium chloride) (PDADMAC), was investigated for bovine serum albumin/β-lactoglobulin (BSA/BLG) and isoforms BLG-A/BLG-B. High-sensitivity turbidimetric titrations were used to define conditions complex formation (pHc pHϕ, respectively) as a function ionic strength. resultant phase boundaries, essential choice chosen protein pairs, are nonmonotonic...
Nitric oxide (NO) is associated with broad-spectrum antimicrobial activity of particular importance in infections caused by intracellular pathogens. An insertion mutation the metL gene Salmonella typhimurium conferred specific hypersusceptibility to S -nitrosothiol NO-donor compounds and attenuated virulence organism mice. The product catalyzes two proximal metabolic steps required for homocysteine biosynthesis. -Nitrosothiol resistance was restored exogenous or introduction on a plasmid....
Abstract Inorganic nanoparticles (NPs) are promising drug delivery carriers owing to their high loading efficiency, scalable preparation, facile functionalization, and chemical/thermal stability. However, the clinical translation of inorganic nanocarriers is often hindered by poor biodegradability lack controlled pH response. Herein, a fully degradable pH‐responsive DOX@ACC/PAA NP (pH 7.4–5.6) developed encapsulating doxorubicin (DOX) in poly(acrylic acid) (PAA) stabilized amorphous calcium...
The binding of bovine serum albumin (BSA) and β-lactoglobulin (BLG) to TTMA (a cationic gold nanoparticle coupled 3,6,9,12-tetraoxatricosan-1-aminium, 23-mercapto-N,N,N-trimethyl) was studied by high-resolution turbidimetry (to observe a critical pH for binding), dynamic light scattering monitor particle growth), isothermal titration calorimetry measure energetics), all as function ionic strength. Distinctively higher affinities observed BLG versus BSA, despite the lower pI latter, were...
In this work, Pt-SnO2 heteroaggregate nanocatalysts were synthesized by in situ transformation of Pt@Sn core–shell nanoparticles and their catalytic performance for hydrogenation various substituted nitroaromatics was investigated. The prepared a one-step method, the alumina-supported further transformed into nanostructures calcination. structures nanomaterials characterized, FT-IR with CO probes, HRTEM, XRD, XPS characterizations revealed that as-synthesized core@shell-like Sn-rich shells...
A series of polymer–carbon nanotube composite materials (CNT-P-SO3H) were prepared by covalent grafting multiwalled carbon nanotubes (CNTs) with sulfonic acid-functionalized polymers (P-SO3H) including poly(3-vinyl-1-sulfonic acid imidazolium chloride)-grafted CNTs (CNT-PVSAIC), poly(4-vinyl-1-sulfonic pyridinium (CNT-PVSAPC), and poly(4-styrenesulfonic acid)-grafted (CNT-PSSA). Such a functionalization method provides facile route to obtain various polyelectrolyte brushes on the surfaces in...
As an emerging semiconductor-based catalyst, g-C 3 N 4 has attracted significant attention for visible light-driven photocatalytic energy conversion, synthesis of chemicals, and environmental remediation.
Renewable and low-cost biochar's intrinsic porous structure limitations make its mediation highly significant for performance enhancement. We employ graphene oxide (GO) as an additive at a low dosage the deed-leaf-derived microporous to promote wastewater treatment ability toward typical antibiotic pollutant - tetracycline hydrochloride (TCH). While KOH-based activation enables biochars with improved graphitization, GO transforms part of micropores such activated biochar into mesopores (i.e....
Abstract Currently, the development of polymeric hole‐transporting materials (HTMs) lags behind that small‐molecule HTMs in inverted perovskite solar cells (PSCs). A critical challenge is conventional are incapable forming ultra‐thin and conformal coatings like self‐assembly monolayers (SAMs), especially for substrates with rough surface morphology. Herein, we address this by designing anchorable (CP1 to CP5). Specifically, coordinative pyridyl groups introduced as side‐chains on...
Summary Bacteria must contend with conditions of nutrient limitation in all natural environments. Complex programmes gene expression, controlled part by the alternative sigma factors σ S ( 38 , RpoS) and H 32 RpoH), allow a number bacterial species to survive partial or complete starvation. We show here that factor E 24 RpoE) also facilitates survival Salmonella typhimurium under deprivation. Expression regulon is strongly induced upon entry into stationary phase. A mutant lacking has...
Pathogenic microorganisms possess antioxidant defense mechanisms for protection from reactive oxygen metabolites such as hydrogen peroxide (H2O2), which are generated during the respiratory burst of phagocytic cells. These include enzymes catalase, detoxify species, and DNA repair systems damage resulting oxidative stress. To determine relative importance these two potentially protective against stress encountered by Salmonella infection host, a typhimurium double mutant unable to produce...
Abstract A light‐driven pseudo[4]rotaxane 1 , based on α‐cyclodextrin (α‐CyD) and cucurbit[7]uril (CB[7]), is prepared in an easy convenient manner. The reference pseudo[2]rotaxane 2 pseudo[3]rotaxane ′ are obtained via the insertion of α‐CyD CB[7] onto dumbbell 3 thus including azobenzene unit two viologen moieties, respectively. CyD macrocycle can be photochemically stimulated to shuttle accompanied with obvious induced circular dichroism (ICD) signals. ICD performances these...
High performance Dopa-modified poly(acrylic acid) adhesives formed under the assistance of zinc ions can transform to a self-recovery polymer hydrogel with pH trigger.