A5067213513- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Biochemical and Structural Characterization
- Machine Learning in Bioinformatics
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
- Advanced battery technologies research
- Chemical Synthesis and Analysis
- Supercapacitor Materials and Fabrication
- Glycosylation and Glycoproteins Research
- Biomedical Text Mining and Ontologies
- Protein Structure and Dynamics
- Conducting polymers and applications
- Advanced Text Analysis Techniques
- Metabolism and Genetic Disorders
- Cancer, Hypoxia, and Metabolism
- Magnetic confinement fusion research
- Advancements in Battery Materials
- Topic Modeling
- Biochemical and Molecular Research
- Laser-Plasma Interactions and Diagnostics
- Electrocatalysts for Energy Conversion
- CO2 Reduction Techniques and Catalysts
- Ionosphere and magnetosphere dynamics
Qilu University of Technology
2021-2023
Shandong Academy of Sciences
2021-2023
Southwestern Institute of Physics
2023
Griffith University
2018-2021
University of Science and Technology of China
2014-2016
Abstract Motivation The recent discovery of numerous non-coding RNAs (long RNAs, in particular) has transformed our perception about the roles living organisms. Our ability to understand them, however, is hampered by inability solve their secondary and tertiary structures high resolution efficiently existing experimental techniques. Computational prediction RNA structure, on other hand, received much-needed improvement, recently, through deep learning a large approximate data, followed...
The accuracy of RNA secondary and tertiary structure prediction can be significantly improved by using structural restraints derived from evolutionary coupling or direct analysis. Currently, these analyses relied on manually curated multiple sequence alignments collected in the Rfam database, which contains 3016 families. By comparison, millions non-coding sequences are known. Here, we established RNAcmap, a fully automatic pipeline that enables analysis for any sequences. homology search...
Abstract Despite the large number of noncoding RNAs in human genome and their roles many diseases include cancer, we know very little about them due to lack structural clues. The centerpiece clues is full RNA base-pairing structure secondary tertiary contacts that can be precisely obtained only from costly time-consuming 3D determination. Here, performed deep mutational scanning self-cleaving CPEB3 ribozyme by error-prone PCR showed a library <5 × 104 single-to-triple mutants...
Noncoding RNAs are increasingly found to play a wide variety of roles in living organisms. Yet, their functional mechanisms poorly understood because structures difficult determine experimentally. As result, developing more effective computational techniques predict RNA becomes an urgent task. One key challenge structure prediction is the lack accurate free energy function guide folding and discriminate native near-native from decoy conformations. In this study, we developed all-atom...
Abstract A vertical edge Thomson scattering (ETS) diagnostic system on HL-2M tokamak has been designed. The ETS collects the scattered light from Nd:YAG laser (1064 nm, 2 J, 30 Hz, 15 ns). beam propagates vertically through plasma region and polarization is parallel to toroidal magnetic field. special designed Galileo-type telescope with long Rayleigh length applied focus size ensure collimation. group of double-Gaussian collection lenses image 600 mm onto rectangular fiber arrays a spatial...
Abstract Motivation The accuracy of RNA secondary and tertiary structure prediction can be significantly improved by using structural restraints derived from evolutionary or direct coupling analysis. Currently, these analyses relied on manually curated multiple sequence alignments collected in the Rfam database, which contains 3016 families. By comparison, millions non-coding sequences are known. Here, we established RNAcmap, a fully automatic method that enables analysis for any sequences....
ABSTRACT Despite the transcription of noncoding RNAs in 75% human genome and their roles many diseases include cancer, we know very little about them due to lack structural clues. The centerpiece clues is full RNA base-pairing structure secondary tertiary contacts that can be precisely obtained only from costly inefficient 3D determination. Here, performed deep mutational scanning self-cleaving CPEB3 ribozyme by error-prone PCR showed a library <5×10 4 single-to-triple mutants sufficient...