A5001945748- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Prostate Cancer Treatment and Research
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Bone health and treatments
- ATP Synthase and ATPases Research
- Berberine and alkaloids research
- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Alkaloids: synthesis and pharmacology
- Cell death mechanisms and regulation
- Sirtuins and Resveratrol in Medicine
- Phytochemicals and Antioxidant Activities
- Adipose Tissue and Metabolism
- Environmental Toxicology and Ecotoxicology
- Synthesis and Biological Activity
- Tea Polyphenols and Effects
- Biochemical and Molecular Research
- Insect and Pesticide Research
University of Lisbon
2017-2024
University of Coimbra
2008-2021
Biocant
2014-2018
In the present work, lipophilic caffeic and ferulic acid derivatives were synthesized, their cytotoxicity on cultured breast cancer cells was compared. A total of six compounds initially evaluated: (CA), hexyl caffeate (HC), caffeoylhexylamide (HCA), (FA), ferulate (HF), feruloylhexylamide (HFA). Cell proliferation, cell cycle progression, apoptotic signaling investigated in three human lines, including estrogen-sensitive (MCF-7) insensitive (MDA-MB-231 HS578T). Furthermore, direct...
Berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(<i>g</i>)-1,3-benzodioxolo(5,6-<i>a</i>)quinolizinium] is an alkaloid present in plant extracts and has a history of use traditional Chinese Native American medicine. Because its ability to arrest the cell cycle cause apoptosis several malignant lines, it received attention as potential anticancer therapeutic agent. Previous studies suggest that mitochondria may be important target berberine, but relatively little known about...
Most metastases in breast cancer occur via the dissemination of tumor cells through bloodstream. How enter blood (intravasation) is, however, a poorly understood mechanism at cellular and molecular levels. Particularly uncharacterized is how intravasation affected by systemic nutrients. High levels LDL-cholesterol have been shown to contribute progression metastasis various models, but mechanisms involved are still undisclosed. Here we show that high- cholesterol diet promotes two mouse...
Most cancer-related deaths are due to metastases. Systemic factors, such as lipid-enriched environments [as low-density lipoprotein (LDL)-cholesterol], favor breast cancer, including triple-negative cancer (TNBC) metastasis formation. Mitochondria metabolism impacts TNBC invasive behavior but its involvement in a setting is undisclosed. Here we show that LDL increases lipid droplets, induces CD36 and augments cells migration invasion vivo vitro. higher mitochondrial mass network spread...
Human skin fibroblasts present technical advantages for the study of mitochondrial-induced toxicity, because those cells can be isolated from patients by lowly invasive methods and specific cumulative cellular damage mutations particular conditions. Several drugs lead to organ with some these having been already withdrawn market. Frequently, drug-induced toxicity is attributed mitochondrial liabilities. One approaches identify using glucose-free/galactose/glutamine/pyruvate-containing cell...