A5075910701- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Alzheimer's disease research and treatments
- Diet and metabolism studies
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Cardiac Ischemia and Reperfusion
- Regulation of Appetite and Obesity
- Neurological Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Adipokines, Inflammation, and Metabolic Diseases
- Structural Engineering and Vibration Analysis
- Neuroscience and Neuropharmacology Research
- Computational Drug Discovery Methods
- Chemotherapy-induced cardiotoxicity and mitigation
- Structural Load-Bearing Analysis
- Eating Disorders and Behaviors
- Wood Treatment and Properties
- Electron Spin Resonance Studies
- Structural Behavior of Reinforced Concrete
- Structural Analysis of Composite Materials
- Tree Root and Stability Studies
University of Coimbra
2016-2024
Lund University
2024
Institute for Sustainability
2022-2024
Centro de Neurociências e Biologia Celular
2021-2022
Biocant
2016-2021
The progression of non-alcoholic fatty liver (NAFL) into steatohepatitis implicates multiple mechanisms, chief which is mitochondrial dysfunction. However, the sequence events underlying failure are still poorly clarified. In this work, male C57BL/6J mice were fed with a high-fat plus high-sucrose diet for 16, 20, 22, and 24 weeks to induce NAFL. Up 20th week, an early remodeling increased OXPHOS subunits levels higher respiration occurred. Interestingly, progressive loss along “Western...
Non-alcoholic fatty liver disease (NAFLD) is a health concern affecting 24% of the population worldwide. Although pathophysiologic mechanisms underlying are not fully clarified, mitochondrial dysfunction and oxidative stress key players in progression. Consequently, efforts to develop more efficient pharmacologic strategies targeting mitochondria for NAFLD prevention/treatment underway. The conjugation caffeic acid anti-oxidant moiety with an alkyl linker triphenylphosphonium cation (TPP+),...
Background and Aims: Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD) architecture NAFLD. Approach Results: Functional studies evaluating LD biology were performed wild‐type (WT) Ripk3 −/− mice fed a choline‐deficient, amino acid‐defined (CDAA) diet for 32 66 weeks CRISPR‐Cas9 ‐null fat‐loaded immortalized...
Parkinson's Disease (PD) is a neurodegenerative disorder affecting more than 10 million people worldwide. Currently, PD has no cure and early diagnostics methods exist. Mitochondrial dysfunction presented in the stages of PD, it considered an important pathophysiology component. We have previously developed mitochondria-targeted hydroxycinnamic acid derivatives, presenting antioxidant iron-chelating properties, preventing oxidative stress several biological models disease. also demonstrated...
Nitrocatechols are the standard pharmacophore to develop potent tight-binding inhibitors of catechol O-methyltransferase (COMT), which can be used as coadjuvant drugs manage Parkinson's disease. Tolcapone is most drug this class, but it has raised safety concerns due its potential induce liver damage. Tolcapone-induced hepatotoxicity been attributed nitrocatechol moiety; however, other nitrocatechol-based COMT inhibitors, such entacapone, safe and do not damage liver. There a knowledge gap...
Non-alcoholic steatohepatitis (NASH), one of the deleterious stages non-alcoholic fatty liver disease, remains a significant cause liver-related morbidity and mortality worldwide. In current work, we used an exploratory data analysis to investigate time-dependent cellular mitochondrial effects different supra-physiological acids (FA) overload strategies, in presence or absence fructose (F), on human hepatoma-derived HepG2 cells. We measured intracellular neutral lipid content reactive oxygen...
Ethnopharmacological Relevance. Doxorubicin (Dox) is an anthracycline antibiotic widely used in cancer treatment. Despite its antitumor efficacy, clinical application significantly limited because of cardiotoxicity originated, among other factors, from pro-oxidant damage to cardiac mitochondria. Phytochemicals represent a potentially attractive strategy mitigate Dox due their antioxidant properties, with plant extracts traditional medicine often being ignored terms potential therapeutic...
Alterations in mitochondrial dynamics, including their intracellular trafficking, are common early manifestations of neuronal degeneration. However, current methodologies used to study trafficking events rely on parameters that primarily altered later stages neurodegeneration. Our objective was establish a reliable applied statistical analysis detect alterations trafficking. We propose novel quantitative mitochondria trajectories based innovative movement descriptors, straightness,...
With the increase in life expectancy and consequent aging of world's population, prevalence many neurodegenerative diseases is increasing, without concomitant improvement diagnostics therapeutics. These share neuropathological hallmarks, including mitochondrial dysfunction. In fact, as alterations appear prior to neuronal cell death at an early phase a disease's onset, study modulation have emerged promising strategies predict prevent neurotoxicity before onset viability alterations. this...
Abstract There is a growing interest in the construction industry to use timber make structures more sustainable. This article discusses using mass flooring panels as part of steel‐framed buildings, covering performance, behaviour and best practice, market challenges sustainability benefits. Embodied carbon comparisons were completed demonstrate environmental benefits hybrid steel frames with floors how they perform against voluntary targets set tackle climate crisis.
<title>Abstract</title> Hypothalamic inflammation underlies diet-induced obesity and diabetes in rodent models. While diet normalization largely allows for recovery from metabolic impairment, it remains unknown whether long-term hypothalamic induced by obesogenic diets is a reversible process. In this study, we aimed at determining sex specificity of neuroinflammation gliosis mice fed fat- sugar-rich diet, their reversibility upon normalization. Mice were 60%-fat complemented 20% sucrose...
Abstract The construction sector activities contribute to irreversible effects on the environmental systems. New forms of are needed increase circular economy and sustainability within built environment. Steel‐concrete composite floors not demountable, because typical shear connection with welded studs is permanent. To avoid demolition promote reuse structural components, demountable systems need be adopted. This article presents a literature review different solutions an overview suitable...
Abstract Hypothalamic inflammation underlies diet-induced obesity and diabetes in rodent models. While diet normalization largely allows for recovery from metabolic impairment, it remains unknown whether long-term hypothalamic induced by obesogenic diets is a reversible process. In this study, we aimed at determining sex specificity of neuroinflammation gliosis mice fed fat- sugar-rich diet, their reversibility upon normalization. Mice were 60%-fat complemented 20% sucrose drink (HFHSD) 3...
With the increase in life expectancy and consequent aging of world&rsquo;s population, prevalence many neurodegenerative diseases is increasing, without concomitant improvement diagnostics therapeutics. These share neuropathological hallmarks, including mitochondrial dysfunction. In fact, as alterations appear prior to neuronal cell death at an early phase disease onset, study modulation rise promising strategies predict prevent neurotoxicity before onset viability alterations. this...