A5004137495- Heme Oxygenase-1 and Carbon Monoxide
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Neonatal Health and Biochemistry
- Malaria Research and Control
- Erythrocyte Function and Pathophysiology
- Cannabis and Cannabinoid Research
- Monoclonal and Polyclonal Antibodies Research
- Chemistry and Stereochemistry Studies
- Glycosylation and Glycoproteins Research
- Engineering and Test Systems
- Scientific Measurement and Uncertainty Evaluation
- T-cell and B-cell Immunology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Reproductive Biology and Fertility
- Parasitic Infections and Diagnostics
- Thyroid Cancer Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Hemoglobin structure and function
- Pregnancy and preeclampsia studies
- Aldose Reductase and Taurine
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Trace Elements in Health
- Endoplasmic Reticulum Stress and Disease
Instituto Gulbenkian de Ciência
2009-2024
University of Alabama
2019
Trudeau Institute
2009
Infection by Plasmodium, the causative agent of malaria, is associated with hemolysis and therefore release hemoglobin from RBC. Under inflammatory conditions, cell-free can be oxidized, releasing its heme prosthetic groups producing deleterious free heme. Here we demonstrate that survival a Plasmodium-infected host relies strictly on ability to prevent cytotoxic effects via expression heme-catabolyzing enzyme oxygenase-1 (HO-1; encoded Hmox1 gene). When infected Plasmodium chabaudi (Pcc),...
Sepsis is an often lethal syndrome resulting from maladaptive immune and metabolic responses to infection, compromising host homeostasis. Disease tolerance a defense strategy against infection that preserves homeostasis without exerting direct negative impact on pathogens. Here, we demonstrate induction of the iron-sequestering ferritin H chain (FTH) in response polymicrobial infections critical establish disease sepsis. The protective effect FTH exerted via mechanism counters iron-driven...
Pregnancy establishment implies the existence of a highly vascularized and transient organ, placenta, which ensures oxygen supply to fetus via haemoproteins. Haem metabolism, including its catabolism by haem oxygenase-1 (HO-1), should be importance in maintaining homeostasis haemoproteins controlling deleterious effects associated with release from maternal or fetal haemoglobins, thus ensuring placental function development. We demonstrate that HO-1 expression is essential promote...
Malaria, the disease caused by Plasmodium spp. infection, remains a major global cause of morbidity and mortality. Host protection from malaria relies on immune-driven resistance mechanisms that kill However, these are not sufficient per se to avoid development severe forms disease. This is accomplished instead via establishment tolerance malaria, defense strategy does target directly. Here we demonstrate tissue damage-control mechanism operates specifically in renal proximal tubule...
Nitric oxide (NO) and carbon monoxide (CO) are gasotransmitters that suppress the development of severe forms malaria associated with Plasmodium infection. Here, we addressed mechanism underlying their protective effect against experimental cerebral (ECM), a form develops in Plasmodium-infected mice, which resembles, many aspects, human (CM). NO suppresses pathogenesis ECM via involving (1) transcription factor nuclear erythroid 2-related 2 (NRF-2), (2) induction heme oxygenase-1 (HO-1), (3)...
Severe presentations of malaria emerge as Plasmodium (P.) spp. parasites invade and lyse red blood cells (RBC), producing extracellular hemoglobin (HB), from which labile heme is released. Here, we tested whether scavenging HB and/or heme, by haptoglobin (HP) hemopexin (HPX), respectively, counter the pathogenesis severe malaria. We found that circulating an independent risk factor for cerebral non-cerebral P. falciparum in children. Labile was negatively correlated with HP HPX, were,...
A doença de chagas, causada pela infecção do parasito Trypanosoma cruzi, é uma das principais doenças tropicais endêmicas da América Central e sul. O objetivo deste estudo foi identificar principalmente na Web of Science – coleção principal (WoS-cc) todos os artigos presentes literatura a respeito chagas em humanos no território brasileiro região amazônica. Trata-se revisão integrativa desenvolvida partir busca nas seguintes bases dados: Science, PubMed, SciELO Google Acadêmico, sem...
Animals deficient in Heme oxygenase-1 (HO-1, Hmox1(-/-) mice) have impaired pregnancies, characterized by intrauterine fetal death. HO-1 expression has been shown to be essential for pregnancy dictating placentation and development. Its absence leads growth restriction loss, which is independent of the immune system. Defect previous steps, e.g., ovulation, may, however, also count their poor reproductive outcome.Here, we investigated ovulation after hormonal hyperstimulation Hmox1 wild-type...
Different techniques of molecular biology have been used to screen for RET rearrangements. More recently, immunohistochemistry has used, assuming that is not expressed in normal thyroid follicular cells. The present study was designed define the prevalence expression patients with papillary carcinoma, by and RT-PCR; search specifically RET/PTC-1; -2; -3 rearrangements using RT-PCR, compare results obtained those RT-PCR. Immunohistochemistry performed a polyclonal antibody against tyrosine...
SUMMARY Most mammals express a functional GGTA1 gene encoding the N-acetyllactosaminide α-1,3-galactosyltransferase enzyme, which synthesizes Galα1-3Galβ1-4GlcNAc (αGal) and are thus tolerant to this self-expressed glycan epitope. Old World primates including humans, however, carry loss-of-function mutations lack αGal. Presumably, fixation of such was propelled by natural selection, favoring emergence αGal-specific immunity, conferred resistance αGal-expressing pathogens. Here we show that...
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