A5024293418- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Diagnosis and treatment of tuberculosis
- Celiac Disease Research and Management
- Helicobacter pylori-related gastroenterology studies
- Neurofibromatosis and Schwannoma Cases
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Microscopic Colitis
- Chromatin Remodeling and Cancer
- Eosinophilic Esophagitis
- Pituitary Gland Disorders and Treatments
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Tuberculosis Research and Epidemiology
- Glycosylation and Glycoproteins Research
- Ocular Oncology and Treatments
- HER2/EGFR in Cancer Research
- Prostate Cancer Diagnosis and Treatment
- Advanced Electron Microscopy Techniques and Applications
- Cancer Mechanisms and Therapy
- Monoclonal and Polyclonal Antibodies Research
University of Turin
1989-2023
Ospedale Regina Margherita
2002-2020
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2014-2019
Ospedale Sant'Anna
2009-2019
Piedmont Reference Center for Epidemiology and Cancer Prevention
2013-2017
Azienda Socio Sanitaria Territoriale Lariana
2017
Italian Institute of Technology
2013
Sapienza University of Rome
2013
Istituto Neurologico Mediterraneo
2013
Infant
2009
Celiac disease (CD)-related lesions have been reported in duodenal bulb biopsies, sometimes the mucosa being only one affected. The aim was to verify a significant series whether histological are always present of celiac patients, what is prevalence when isolated bulb, and if similar nonceliac subjects.We studied 665 children with CD (241 males, range 9 months-15 years, 8 months), at diagnosis on gluten-containing diet, 348 age- sex-matched gastroenterological controls submitted upper...
We previously showed that disruptive complex I mutations in mitochondrial DNA are the main genetic hallmark of oncocytic tumors thyroid and kidney. here report a high frequency homoplasmic large panel pituitary head-and-neck tumors. The presence such implicates disassembly respiratory vivo which turn contributes to inability stabilize HIF1α display pseudo-hypoxia. By utilizing transmitochondrial cytoplasmic hybrids (cybrids), we induced shift homoplasmy truncating mutation mitochondria-coded...
Abstract The optimal combination of bevacizumab with cytotoxic or cytostatic drugs in recurrent glioblastoma is unknown. We performed a phase 2 trial combined and fotemustine for patients at first relapse after radiotherapy temozolomide. primary endpoint was 6-month progression-free survival (PFS), while secondary endpoints were overall (OS), response rate based on RANO criteria toxicity. Fifty-four GBM enrolled. authors observed PFS 42.6 % (95 CI 29.3–55.2) median 5.2 months 3.8–6.6). OS...
Ependymomas (EPs) are tumors of the brain and spinal cord constituting ∼10% childhood central nervous system neoplasms about 30% in children aged <3 years. Their anatomic distribution varies according to age, with those arising supratentorial (ST) compartment, being more common older adults, at infratentorial location occurring frequently infants children. Recently, molecular classification EP subgroups has been proposed a ependymoma subgroup characterized by RELA-fusion genes...
To evaluate the efficacy of amoxycillin in eradicating Campylobacter pylori, endoscopic biopsy specimens were taken from antral mucosa 40 children with gastritis before, immediately after, and (in 30 patients) three months after treatment. Immediately treatment 34 patients (85%) no longer had organism mucosa, healed 23 (58%). Three later infection recurred 22 (73%), relapsed all them. Significantly more whom C pylori family histories peptic ulcer disease. The results suggest that alone is...
Clustered protocadherins (PCDHs) map in tandem at human chromosome 5q31 and comprise three multi-genes clusters: α-, β- γ-PCDH. The expression of this cluster consists a complex mechanism involving DNA hub formation through DNA-CCTC binding factor (CTCF) interaction. Methylation alterations can affect interaction, leading to transcriptional dysregulation. In cancer, clustered PCDHs undergo long-range epigenetic silencing by hypermethylation.In study, we detected frequent methylation CpG...
RET is a tyrosine kinase transmembrane receptor expressed in two main alternative isoforms: RET9 and RET51. transduces positive signal leading to survival, differentiation, or migration the presence of its ligand glial cell line-derived neurotrophic factor, whereas absence proapoptotic fragment that initiates negative signaling for apoptosis generated. The transduction mechanisms are still unclear.To shed light on RET-induced apoptosis, we searched novel interactors RET51.The "split...
Mitochondrial DNA (mtDNA) mutations leading to the disruption of respiratory complex I (CI) have been shown exhibit anti-tumorigenic effects, at variance with those impairing only function but not assembly complex, which appear contribute positively cancer development. Owing challenges in analysis multi-copy mitochondrial genome, it is yet be determined whether tumour-associated mtDNA lesions occur as somatic modifying factors or germ-line predisposing elements. Here we investigated whole...
Several molecular biomarkers have been suggested as predictors of outcome for pediatric ependymomas but deserve further validation in independent case series. We analyzed intracranial belonging to a series 60 patients prospectively treated according the protocol sponsored by Italian Association Pediatric Hematology-Oncology. used tissue microarray analyze nucleolin (NCL), cyclin-dependent kinase inhibitor 2A (CDKN2A), tumor protein 53 (TP53), and epidermal growth factor receptor (EGFR)...
Abstract Background A prospective 2002–2014 study stratified 160 patients by resection extent and histological grade, reporting results in 2016. We re-analyzed the series after a median of 119 months, adding retrospectively patients’ molecular features. Methods Follow-up all was updated. DNA copy number analysis gene-fusion detection could be completed for 94/160 patients, methylation classification 68. Results Progression-free survival (PFS) overall (OS) at 5/10 years were 66/58%, 80/73%....
Aquaporin-4 (AQP-4), the most important water channel in brain, is expressed by astrocyte end feet abutting microvessels. Altered expression levels of AQP-4 and redistribution protein throughout membranes cells found glioblastoma multiforme (GBM) lead to development edema often surrounding tumor mass. Dysregulation also occurs hippocampal sclerosis cortical dysplasia patients with refractory partial epilepsy. This work reports on analysis relationship between incidence epileptic seizures...
High-grade gliomas (HGGs) account for 15% of all pediatric brain tumors and are a leading cause cancer-related mortality morbidity. Pediatric HGGs (pHGGs) histologically indistinguishable from their counterpart in adulthood. However, recent investigations indicate that differences occur at the molecular level, thus suggesting path to gliomagenesis childhood is distinct adults. MicroRNAs (miRNAs) have been identified as key molecules gene expression regulation, both development cancer. miRNAs...
The Ras signaling pathway, consisting of mitogen‐activated protein kinase (MAPK) and PI3K/AKT signaling, is a prominent oncogenic pathways in adult diffuse gliomas, but few studies have evaluated such pediatric malignant gliomas. We investigated by immunohistochemistry MAPK AKT series 28 high‐grade gliomas (WHO grade III IV). sought possible association phospho‐ERK (p‐ERK) phospho‐AKT (p‐AKT) with expression other proteins involved the that is, YKL40, epidermal growth factor receptor (EGFR),...
Glioblastoma (GBM) is known as an intractable, highly heterogeneous tumor encompassing multiple subclones, each supported by a distinct glioblastoma stem cell (GSC). The contribution of GSC genetic and transcriptional heterogeneity to subclonal properties debated. In this study, we describe the systematic derivation, propagation, characterization GSCs from single, treatment-naive GBMs (GSC families). tumorigenic potential better correlates with its profile than make-up, classical being...
In adult medulloblastoma, postoperative radiotherapy is significantly effective in prolonging time to recurrence and survival time; however, the response of individual cases radiotherapy, that total survival, different. Apoptosis an important cellular radiation. It can be hypothesized radiosensitivity medulloblastomas depends on capability undergo apoptosis. p53 protein involved apoptotic ionizing radiation; loss function consequence not only TP53 mutations, but also amplification and/or...
Frequency of mucosal damage to the esophagus, stomach, and duodenum was investigated in 176 children with coeliac disease (CD) during 230 upper GI endoscopies performed obtain duodenal biopsy specimens compared findings age-matched who underwent endoscopy for complaints without CD (non-CD patients). To evaluate a possible association gluten ingestion, we then frequency patients on gluten-containing diet those gluten-free Diet (GFD). In CD, esophageal seen at peptic esophagitis shown by...
Higher-grade meningiomas (WHO grade II and III) represent a diagnostic prognostic challenge. We assessed the pathological molecular characteristics of 94 higher-grade (85 II, 9 to identify novel parameters. Higher mitotic count (p = 0.018), diffuse (≥50%) prominent nucleoli < 0.001), sheeting 0.001) were associated with recurrence. Lower SSTR2a-positive cells median rate 0.048) TERT promoter mutations 0.014) recurrence patient death, respectively; further analyses did not other outcome...
// Gloria Mittica 1, 2, * , Rebecca Senetta 3, Giulia Scotto 1 Massimo Aglietta 2 Furio Maggiorotto 4 Eleonora Ghisoni Sofia Genta Renzo Boldorini 5 Claudia Manini 6 Isabella Morra 7 Roberta Buosi 8 Anna Sapino 9 Paola Cassoni 9, and Giorgio Valabrega Department of Oncology, University Turin, Italy Division Medical Oncology-1, Candiolo Cancer Institute-FPO- IRCCS, Candiolo, 3 Unit Pathology Gynecologic Health Science, Eastern Piedmont "Amedeo Avogadro", Novara, Pathology, Giovanni Bosco...
// Manila Antonelli 1, * , Antonio Fadda 2, Eleonora Loi 2 Loredana Moi 3 Cesare Zavattari 4 Pia Sulas 5 Davide Gentilini 6, 7 Cinzia Cameli 8 Elena Bacchelli Manuela Badiali Antonella Arcella 9 Isabella Morra 10 Felice Giangaspero and Patrizia 1 Department of Radiological, Oncological Anatomo-Pathological Sciences, University Sapienza Rome, Italy Unit Biology Genetics, Biomedical Cagliari, Bone Marrow Transplantation Unit, Microcitemico Children's Hospital, Independent Researcher, Machine...