A5100782755- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Ovarian function and disorders
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Renal Diseases and Glomerulopathies
- Drug Transport and Resistance Mechanisms
- Cystic Fibrosis Research Advances
- Cardiovascular Disease and Adiposity
- Reproductive System and Pregnancy
- Renal Transplantation Outcomes and Treatments
- Pharmacovigilance and Adverse Drug Reactions
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- SARS-CoV-2 and COVID-19 Research
- Inflammation biomarkers and pathways
- Pharmaceutical studies and practices
- Pancreatitis Pathology and Treatment
- Neonatal and Maternal Infections
- Natural Compounds in Disease Treatment
- Antibiotics Pharmacokinetics and Efficacy
- PI3K/AKT/mTOR signaling in cancer
- Circular RNAs in diseases
Shanghai Jiao Tong University
2016-2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Shanghai Children's Medical Center
2024
Shanghai Children's Hospital
2016-2023
Renji Hospital
2021
Minhang District Central Hospital
2021
Shantou University
2005-2020
Third Xiangya Hospital
2020
Central South University
2020
Although hyperandrogenism is an important condition and considered the possible pathogenesis behind polycystic ovary syndrome (PCOS), data supporting this still scarce. We sought to determine whether or not prenatal androgen exposure leads PCOS cellular mechanisms involved. To induce exposure, pregnant rats were treated with daily subcutaneous injections of free testosterone (T) dihydrotestosterone (DHT) from embryonic days 16 19, their female offspring studied as adults. The mRNA expression...
ABSTRACT: Human semen cryopreservation in the clinical management of male infertility is complicated by cryodamage to spermatozoa. We aimed clarify full pattern and evaluate protective effects ascorbate catalase on cryopreserved Semen samples were collected from 30 fertile males. Each sample was divided into 6 groups: fresh semen, without treatment, with (300 or 600 μM) (200 400 IU/mL). Spermatozoa examined for their viability, motility, reactive oxygen species (ROS) generation,...
The main goal of our study was to characterize the population pharmacokinetics vancomycin in critically ill Chinese neonates develop a pharmacokinetic model and investigate factors that have significant influences on this population. consisted 80 neonatal intensive care unit (ICU) from which 165 trough peak concentrations were obtained. Nonlinear mixed effect modeling used for vancomycin. stability predictive ability final evaluated based diagnostic plots, normalized prediction distribution...
Pleural effusion, pericardial and pulmonary arterial hypertension have been shown to potential associations with the use of dasatinib in adults. However, due limited data regarding efficacy safety tyrosine kinase inhibitors (TKIs) pediatric patients necessities reliance on clinical experience gained from treating
Abstract Immunoglobulin G (IgG), the major molecule of immune system, which was traditionally thought to be produced by differentiated B-lymphocytes, had recently been found in non-immune cells including spermatozoa rabbit testis. To study if human sperms could produce IgG that might play a role fertilization, we employed immunofluorescent staining, Western blot, situ hybridization, RT-PCR (reverse transcription polymerase chain reaction) and immunoelectron microscope were capable...
Background: Although kidney injury has been reported as a serious adverse effect in patients treated with ibuprofen or acetaminophen (APAP), there are still few real-world studies to compare the specific differences effects of nephrotoxicity. Methods: Disproportionality analysis and Bayesian were devoted data-mining suspected after using APAP based on FDA's Adverse Event Reporting System (FAERS) from January 2004 March 2021. The times onset, fatality, hospitalization rates...
Ginsenoside Rg3 has been reported to exert protection function on germ cells. However, the mechanisms by which regulates apoptosis in mouse Leydig cells remain unclear. In addition, triptolide (TP) induce infertility male rats. Thus, this study aimed investigate protective effect of against TP-induced toxicity MLTC-1 cells.CCK-8, immunofluorescence assay, Western blotting and flow cytometry were used detect cell proliferation apoptosis, respectively. dual luciferase reporter system assay was...
Background: Stevens-Johnson syndrome (SJS) has been reported as a serious adverse effect in patients treated with vancomycin or linezolid, and there is currently lack of real-world studies comparing specific differences effects SJS. Methods: According to the FDA's Adverse Event Reporting System (FAERS), from January 2004 July 2021, data suspected SJS after use linezolid were analyzed by imbalance Bayesian analysis. The onset time, fatality rate hospitalization vancomycin-associated...
Resistance to HER2-targeted therapy is the major cause of treatment failure in patients with HER2+ breast cancer (BC).Given key role immune microenvironment tumor development, there a lack an ideal prognostic model that fully accounts for infiltration.In this study, WGCNA analysis was performed discover relationship between immune-related signaling and prognosis BC.After Herceptin-resistant BC cell lines established, transcriptional profiles resistant line RNA-sequencing data from GSE76360...
Polycystic ovary syndrome (PCOS) is associated with an increased risk of cardiovascular disease in women. Hyperhomocysteinemia (H-Hcy) closely related to arterial stiffness (AS) patients disease. This study aimed investigate the relationship between serum homocysteine(Hcy) level and brachial-ankle pulse wave velocity (baPWV) Chinese women PCOS. A total 124 PCOS were enrolled divided into two groups according their baPWV values: normal, < 1400 cm/s high AS, ≥ cm/s. Univariate analysis was...
Abstract Backgrounds Interleukin-6 (IL-6) blockers including tocilizumab and sarilumab were approved by the U.S. Food Drug Administration (FDA) in June 2021 for treatment of patients with moderate to severe COVID-19. The use or COVID-19 has been related a reduction mortality compared standard care. Recent evidence emerged concerning drug-induced liver injury (DILI) after applications patients. Aims study aimed estimate DILI associated treating infected SARS-Cov-2. Methods We conducted...
Abstract Recent evidence has emerged concerning delayed cutaneous hypersensitivity reactions after infliximab or adalimumab applications in patients with coronavirus disease 2019 (COVID‐19). A few real‐world studies compared the events, clinical features, and prognosis of infliximab‐ adalimumab‐related COVID‐19 patients. Disproportionality analysis Bayesian were utilized to determine suspected adverse events use based on Food Drug Administration's Adverse Event Reporting Systems (FAERS) from...
Background: This study aimed to investigate the regulative work between Naringin and macrophages on progression of intestinal injury induced by Lipopolysaccharide (LPS).Methods: Cecal ligation puncture (CLP) was used build animal model sepsis. followed a series experiments including RT-PCR, western blotting, immunohistochemistry (IHC), flow cytometric analyses detect genes proteins expressions, macrophage phenotypes. ChIP assay employed determine interplay PPARγ promoter luciferase reporter...
Objective To observe sperm changes before and after the preparation of density gradient centrifugation swim-up,to confirm role preferred technology in improvement quality sperm,and to explore internal relations between them.Methods Semen samples were prepared by (the swim-up).Then early apoptosis,mitochondrial membrane potential,reactive oxygen specials evaluated flow cytometry analysis.Sperm parameters examined computer assisted analysis.The nDNA integrity was single cell gel...