A5080233598- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Trypanosoma species research and implications
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- SARS-CoV-2 and COVID-19 Research
- Congenital Heart Disease Studies
- Liver Disease and Transplantation
- Coronary Artery Anomalies
- Liver Disease Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Climate Change and Health Impacts
- COVID-19 and Mental Health
- Pressure Ulcer Prevention and Management
- Pericarditis and Cardiac Tamponade
- Cardiac Arrhythmias and Treatments
- Voice and Speech Disorders
- Vitamin C and Antioxidants Research
- Immune Cell Function and Interaction
D’Or Institute for Research and Education
2020-2025
Duke Medical Center
2020
Fundação Oswaldo Cruz
2020
Instituto Nacional de Cardiologia
2020
<h3>Importance</h3> It is unknown whether angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) have a positive, neutral, negative effect on clinical outcomes in patients with coronavirus disease 2019 (COVID-19). <h3>Objective</h3> To determine discontinuation compared continuation of ACEIs ARBs changed the number days alive and out hospital through 30 days. <h3>Design, Setting, Participants</h3> A randomized trial 659 hospitalized Brazil mild to...
COVID-19 has become a dramatic health problem during this century. In addition to high mortality rate, survivors are at increased risk for cardiovascular diseases 1-year after infection. Explanations these manifestations still unclear but can involve constellation of biological alterations. We hypothesized that compared with controls exhibit sympathetic overdrive, vascular dysfunction, cardiac morpho-functional changes, impaired exercise capacity, and oxidative stress.Nineteen severe 19...
Background: Cardiovascular comorbidities such as hypertension and inflammatory response dysregulation are associated with worse COVID-19 prognoses. Different cytokines have been proposed to play vital pathophysiological roles in progression, but appropriate prognostic biomarkers remain lacking. We hypothesized that the combination of immunological clinical variables at admission could predict progression hypertensive patients. Methods: The levels biomarkers, including C-reactive protein,...
Background: We have recently showed that severe COVID patients neurovascular dysfunction, cardiac morpho-functional alterations, and attenuated exercise capacity. However, whether these alterations persist over time is unknown. Here, we tested the hypothesis Long patients, even 2 years after SARS-COV-2 infection, exhibit sympathetic overdrive, aortic stiffening, endothelium-dependent changes, diminished Methods: Eighteen 19 well-matched controls were studied. Muscle nerve activity (MSNA;...
Chronic Chagas disease can progress to myocardial involvement with intense fibrosis, which may predispose patients sudden cardiac death through ventricular arrhythmia. The associations of fibrosis detected by magnetic resonance (CMR) parameters non-sustained tachycardia (NSVT) were evaluated. This cross-sectional study included in early stages (n = 47) and a control group 15). Patients underwent evaluation, including CMR examination. Myocardial assessment measurement late gadolinium...
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, and its presentation differs according to age sex. Recent studies have revealed differences in AF among various demographic groups, including Latin American population.
Previous studies show that COVID-19 survivors have elevated muscle sympathetic nerve activity (MSNA), endothelial dysfunction, and aortic stiffening. However, the neurovascular responses to mental stress exercise are still unexplored. We hypothesized survivors, compared with age- body mass index (BMI)-matched control subjects, exhibit abnormal physical exercise. Fifteen severe (aged: 49 ± 2 yr, BMI: 30 1 kg/m ) 15 well-matched subjects 46 3 29 were studied. MSNA (microneurography), forearm...
Cardiovascular comorbidities and immune-response dysregulation are associated with COVID-19 severity. We aimed to explore the key immune cell profile understand its association disease progression in 156 patients hypertension that were hospitalized due COVID-19. The primary outcome was severe disease. probability of estimated using a logistic regression model included clinical variables subsets outcome. Obesity; diabetes; oxygen saturation; lung involvement on computed tomography (CT)...
Abstract The abnormal hemodynamics in Fontan circulation due to persistently increased systemic venous pressure results hepatic congestion and Fontan-associated liver disease. Combined assessment of cardiac fibrosis remodeling using multiparametric MRI this context have not been fully explored. To evaluate patients who undergone procedures. Thirty-eight 23 controls underwent examinations a 3.0-T scanner. Mann–Whitney, Fisher exact test, Spearman’s correlation were applied myocardial volumes,...
Chronic Chagas heart disease has different clinical manifestations including arrhythmias, failure, and stroke. Chest pain is one of the most common symptoms when associated with changes in electrocardiogram, such as T-wave changes, electrically inactive areas, segmental wall motion abnormalities, may lead to a misdiagnosis acute coronary syndrome (ACS). Here, we describe two patients syncope due sustained ventricular tachycardia who were misdiagnosed ACS, discuss role novel imaging...
Myocardial injury (MI), defined by troponin elevation, has been associated with increased mortality and adverse outcomes in patients coronavirus disease 2019 (COVID-19), but the role of this biomarker as a risk predictor remains unclear. Data from adult hospitalized COVID-19 were recorded prospectively. A multiple logistic regression model was used to quantify associations all variables in-hospital mortality, including calculation odds ratios (ORs) confidence intervals (CI). Troponin...
(1) Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases worldwide. Although cardiovascular and NAFLD risk factors overlap, an independent association between these conditions may exist. Hepatic cardiac fibrosis are important markers mortality, but correlation in patients with has not been well studied. Our main objective was to determine degree myocardial its severity fibrosis. (2) Methods: In this cross-sectional study, were allocated two groups...