A5061061773- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Crustacean biology and ecology
- Glaucoma and retinal disorders
- Animal Behavior and Reproduction
- Retinal and Macular Surgery
- Genomics and Chromatin Dynamics
- Polysaccharides and Plant Cell Walls
- Plant and animal studies
- Retinal Development and Disorders
- Marine and fisheries research
- Ocular Diseases and Behçet’s Syndrome
- Coral and Marine Ecosystems Studies
- Intraocular Surgery and Lenses
- Polysaccharides Composition and Applications
- RNA Research and Splicing
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Immune Response and Inflammation
- Advanced Statistical Methods and Models
- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- Anomaly Detection Techniques and Applications
Kyoto University
2009-2024
Nara University of Education
2019-2024
Japan Wildlife Research Center
2016-2024
Aureo (Japan)
2012-2023
Hokkaido University of Science
2012-2023
Universidade Federal do Amazonas
2023
Ōtani University
2023
Tokyo Medical University
2013-2022
RIKEN
2013-2017
Tokyo Medical University Ibaraki Medical Center
2014-2015
A common haplotype on 10q26 influences the risk of age-related macular degeneration (AMD) and encompasses two genes, LOC387715 HTRA1. Recent data have suggested that loss LOC387715, mediated by an insertion/deletion (in/del) destabilizes its message, is causally related with disorder. Here we show insufficient to explain AMD susceptibility, since a nonsense mutation (R38X) in this gene leads message resides protective haplotype. At same time, disease tagged in/del rs11200638 has effect...
SUV39H is the major histone H3 lysine 9 (H3K9)-specific methyltransferase that targets pericentric regions and crucial for assembling silent heterochromatin. recognizes trimethylated H3K9 (H3K9me3) via its chromodomain (CD), enriched H3K9me3 allows to target specific chromosomal regions. However, detailed targeting mechanisms, especially naïve chromatin without preexisting H3K9me3, are poorly understood. Here we show Suv39h1’s CD (Suv39h1-CD) binds nucleic acids, this binding important...
In Brief Purpose: To evaluate the anatomical and functional outcome of inverted internal limiting membrane (ILM) flap technique with vitrectomy for retinal detachment associated macular hole (MHRD) in highly myopic eyes. Methods: this retrospective observational study, 21 eyes MHRD that underwent conventional ILM peeling (ILM-peeling group, n = 11) or (ILM 10) combined C3F8 tamponade were enrolled study. The initial reattachment rate, closure postoperative visual acuity at final visit...
β-(1→3)-D-glucans with β-(1→6)-glycosidic linked branches produced by mushrooms, yeast and fungi are known to be an immune activation agent, used in anti-cancer drugs or health-promoting foods. In this report, we demonstrate that oral administration of Aureobasidium pullulans-cultured fluid (AP-CF) enriched the β-(1→3),(1→6)-D-glucan exhibits efficacy protect mice infected a lethal titer A/Puerto Rico/8/34 (PR8; H1N1) strain influenza virus. The survival rate significantly increased AP-CF...
To investigate whether vitreous and aqueous humor concentrations of vascular endothelial growth factor (VEGF) predict postoperative complications after vitrectomy for proliferative diabetic retinopathy (PDR).Sixty eyes 52 patients with PDR who underwent were enrolled. Vitreous obtained from during primary the levels VEGF measured using a commercial flow cytometer. Patients followed more than 6 months surgery. Demographic data both intraoperative findings recorded. The relationship between in...
To evaluate the efficacy and safety of verteporfin photodynamic therapy (V-PDT) for young adults children with subfoveal choroidal neovascularization (CNV) associated toxoplasmic retinochoroiditis.Patients CNV retinochoroiditis were treated V-PDT prospectively followed up. Before during follow-up, patients underwent visual acuity testing, complete ophthalmic examination including color photography, angiography fluorescein and/or indocyanine green, optical coherence tomography. The decision...
To evaluate the 3-dimensional architecture of neovascularization in proliferative diabetic retinopathy using Doppler optical coherence tomography (OCT).Prospective, nonrandomized clinical trial.Seventeen eyes 14 patients with were prospectively studied. Prototype OCT was used to vascular at vitreoretinal adhesions.Proliferative membranes detected all by standard images. images blood flow disc 12 and elsewhere 11 eyes. showed extent new vessels various stages neovascularization, could be...
Background/Aims To investigate real-world outcomes for best-corrected visual acuity (BCVA) after 2-year clinical intervention treatment-naïve, centr-involving diabetic macular oedema (DME). Methods Retrospective analysis of longitudinal medical records obtained from 27 institutions specialising in retinal diseases Japan. A total 2049 eyes with treatment-naïve DME commencing between 2010 and 2015 who were followed 2 years eligible. Interventions included anti-vascular endothelial growth...
Betanin is a red pigment of beetroot ( Beta vulgaris L.), providing the beneficial effects to maintain human health. involved in characteristic color beetroot, and used as an edible dye. known be highly unstable pigment, water solutions betanin are nearly fully degraded after heating at 99°C for 60 min experimental conditions this study. The present study investigated juice (RBJ) on immune cells, found that stimulation with RBJ induces interleukin (IL)-1β, IL-8, IL-10 mRNA monocyte derived...
Infection of influenza A virus in mammals induces hyper lung pneumonia, which often causes lethal diseases. FasL is a specific ligand Fas, type-I transmembrane protein to induce cell death. Previously, it has been reported that the induction gene expression associated with Fas signal observed infection. More importantly, was also functional mutation protects host against These observations suggest functionally severity influenza. However, regulation or by infection still unknown. Here, we...
Pericentric regions form epigenetically organized silent heterochromatin structures that accumulate histone H3 lysine 9 trimethylation (H3K9me3) and HP1. At pericentric regions, Suv39h is the major enzyme generates H3K9me3. also interacts directly with HP1, a methylated H3K9-binding protein. However, it not well characterized how HP1 interaction important for accumulation Suv39h-mediated H3K9me3 formation at pericentromere. To address this, we introduced binding-defective N-terminally...
Background/aims To investigate the yearly change of real-world outcomes for best corrected visual acuity (BCVA) after 2-year clinical intervention treatment-naïve diabetic macular oedema (DMO). Methods Retrospective analysis aggregated, longitudinal medical records obtained from 27 retina specialised institutions in Japan Survey Treatment DMO database. A total 2049 centre involving eyes which initial started between 2010 and 2015, had been followed 2 years, were eligible. As interventions,...
A β-glucan produced by Aureobasidium pullulans (AP-PG) is consisting of a β-(1,3)-linked main chain with β-(1,6)-linked glucose side residues. Various β-glucans including AP-PG are believed to exhibit anti-tumor activities, and actually, activities in mice have been demonstrated. In this study, we demonstrate that stimulation induces TRAIL expression mouse human macrophage-like cell lines. known be cytokine which specifically apoptosis transformed cells, but not untransformed cells. The mRNA...
Aureobasidium pullulans-derived β-glucan (AP-PG) consisting of a β-(1,3)-linked glucose main chain and β-(1,6)-linked branches is taken as supplement to improve health. This study demonstrates that oral administration AP-PG effective prevent the development high-fat diet (HFD)-induced fatty liver in mice. Here, C57BL/6N mice were fed with normal or HFD, diluted drinking water was administered orally. After 16 weeks, serological analysis showed HFD-induced high blood cholesterol triglyceride...
Abstract Background The β–(1 → 3),(1 6)-D-glucan extracellularly produced by Aureobasidium pullulans exhibits immunomodulatory activity, and is used for health supplements. To examine the effects of oral administration to domestic animals, a small scale study was conducted using Holstein cows newborn Japanese Black calves. Findings which somatic cell count less than 3 x 10 5 /ml were orally administered with or without β-(1 6)-D-glucan-enriched A. cultured fluid (AP-CF) months, properties...
The purpose of this study was to investigate whether vitreous levels vascular endothelial growth factor (VEGF) predict late hemorrhage (VH) after vitrectomy for proliferative diabetic retinopathy, and how VEGF level changes in patients with postoperative VH.Eighty-five eyes 68 retinopathy who underwent were analyzed retrospectively. Vitreous samples collected from undergoing primary VH second vitrectomy. measured using enzyme-linked immunosorbent assay. relationship between (>4 weeks)...
The larches, the Larix genus of plants are known as a natural source taxifolin (dihydroquercetin), and extracts its rich xylem used in dietary supplements to maintain health. In present study, assess biological activities methanol extract Japanese larch, kaempferi (LK-ME), effects LK-ME on cell viability, inflammatory cytokine expression, glycation were investigated. which is be main compound LK-ME, related flavonoids, quercetin luteolin also examined. results show that exhibits lower growth...
The Japanese larch, (Larix kaempferi) is known to contain abundant taxifolin (dihydroquercetin) in its xylem. In this study, assess the bioactivities of rich methanol extract L. kaempferi (LK-ME), anti-inflammatory effect, and anti-lipid accumulation effect LK-ME were investigated. results showed that nitric oxide (NO) reactive oxygen species (ROS) reduced after treatment with LK-ME, lipid adipocyte differentiated 3T3-L1 cells was inhibited grown medium containing LK-ME. Taxifolin, major...
Pericentric regions form epigenetically organized, silent heterochromatin structures that accumulate histone H3 lysine 9 tri-methylation (H3K9me3) and protein 1 (HP1), a methylated H3K9-binding protein. At pericentric regions, Suv39h is the major enzyme generates H3K9me3. also interacts directly with HP1. However, importance of HP1 interaction for Suv39h-mediated H3K9me3 formation at pericentromere not well characterized. To address this question, we introduced binding-defective,...