A5084010872- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Pharmacovigilance and Adverse Drug Reactions
- Pharmacological Receptor Mechanisms and Effects
- Drug-Induced Adverse Reactions
- Chemical Synthesis and Analysis
- Drug Transport and Resistance Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Blood Pressure and Hypertension Studies
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Hormonal Regulation and Hypertension
- Trace Elements in Health
- Nausea and vomiting management
- Ferroptosis and cancer prognosis
- Cannabis and Cannabinoid Research
- Liver Disease and Transplantation
- Heart Rate Variability and Autonomic Control
- Sodium Intake and Health
- Lung Cancer Treatments and Mutations
- Pain Mechanisms and Treatments
- Organ Transplantation Techniques and Outcomes
- Neutropenia and Cancer Infections
Osaka University of Pharmaceutical Sciences
2016-2024
Kyushu University
2018
Jichi Medical University
2010-2017
Kyoto University
2013
Jichi Medical University Hospital
2011
Aichi Cancer Center
2011
Mayo Clinic in Arizona
2005-2011
Kyoto University Hospital
2008-2009
Tohoku University
2007
Scripps Research Institute
2007
Objective The potential influence of the multidrug resistance 1 (MDR1) gene and cytochrome P450 (CYP) genes, CYP3A4 CYP3A5, on oral clearance (CL/F) tacrolimus in adult living-donor liver transplant patients was examined. Furthermore, development renal dysfunction analyzed relation to CYP3A5 genotype. Methods Sixty de novo receiving were enrolled this study. effects various covariates (including intestinal hepatic mRNA levels MDR1 CYP3A4, measured each tissue taken at time transplantation,...
Drug-induced nephrotoxicity is a serious problem in patients with hospital-acquired acute kidney injury (AKI). A new renal biomarker needed because traditional markers are not sensitive for early detection of drug-induced AKI. In recent study, we demonstrated that vanin-1 novel candidate nephrotoxicant-induced injury. The objective the present study to determine whether increase urinary detected before elevations serum creatinine or <i>N</i>-acetyl-β-glucosaminidase (NAG), molecule-1...
What is known and objective Acute kidney injury (AKI) often occurs in hospitalized patients, it an increasing problem worldwide. Recently, clinical studies have shown that there a strong association between drug-induced AKI poor outcomes, including the progression of chronic disease end-stage renal disease; however, limited data are available on AKI. The purpose this study was to clarify rank-order all drugs with using spontaneous reporting system database. Methods We performed retrospective...
On the basis of structure−activity relationships δ-opioid-selective peptide ligands and on a model proposed bioactive conformation for potent selective, conformationally constrained δ-opioid ligand [(2S,3R)-TMT1]DPDPE, series small organic mimetic compounds targeted receptor have been designed, synthesized, evaluated in radiolabeled binding assays vitro bioassays. The new non-peptide use piperazine as template to present most important pharmacophore groups, including phenol phenyl groups...
To assess the effects of intestinal cytochrome P450 2C19 on interaction between tacrolimus and proton pump inhibitors, we examined concentration/dose ratio [(ng/ml)/(mg/day)] coadministered with omeprazole (20 mg) or lansoprazole (30 to 89 adult living-donor liver transplant patients postoperative days 22 28, considering <i>CYP2C19</i> genotypes native intestine graft liver, separately. The was significantly higher in two variants (<i>*2</i> <i>*3</i>) for CYP2C19 (median, 6.38; range,...
We examined the influence of CYP2C19 polymorphisms on antiplatelet effects clopidogrel and ticlopidine. The platelet aggregation induced by 20 µmol/l adenosine diphosphate (ADP) single-nucleotide (*2 *3) was determined in patients with coronary artery disease (CAD) who were taking aspirin alone (n = 21), plus 97), or ticlopidine 47). degree group, although not depended polymorphism, maximal poor metabolizers (PMs) equivalent to that group alone. After being switched from ticlopidine, all...
Background: Vanin-1 is a novel acute kidney injury (AKI) biomarker that has not been clinically investigated as for obstructive nephropathy. This study the diagnostic value of vanin-1 adult nephropathy by comparing it to existing AKI biomarkers. Methods: A total 49 patients, 21 controls, and 28 hydronephrosis (HN) cases were assessed. biomarkers in bladder (BL) urine renal pelvic (RP) HN group compared each BL marker control group. In subgroup receiving interventions nephropathy, values...
Background: Development of acute kidney injury (AKI) depends on the severity renal dysfunction, clinical setting, comorbid factors, and geographical location. Gastric cancer is one deadliest malignancies worldwide, its incidence significantly high in Japan. Objective: We analyzed rank-order association anticancer agents for gastric with AKI using a spontaneous reporting system database, Japanese Adverse Drug Event Report database. Methods: performed retrospective pharmacovigilance...
The molecular basis of ligand binding and activation family B G protein-coupled receptors is not yet clear due to the lack insight into structure intact receptors. Although NMR crystal structures amino-terminal domains several members support consistency in general structural motifs that include a peptide-binding cleft, there are variations details docking carboxyl terminus peptide ligands within this no information about siting amino these peptides. There also empirical data orient receptor...
Background: Acute pancreatitis (AP) is associated with risks of morbidity and mortality. The incidence AP recently increased compared to that traditionally reported in the literature. Objective: purpose this study was evaluate possible association between drugs using Japanese Adverse Drug Event Report (JADER) database, which a spontaneous reporting database adverse drug events. Methods: event reports submitted JADER 2004 2017 were analyzed. Disproportionality analysis performed by...
Purpose: Bendamustine is used in hematologic malignancies such as non-Hodgkin lymphoma, chronic lymphocytic leukemia, and multiple myeloma. This study evaluated the association of bendamustine-related skin disorders using Japanese Adverse Drug Event Report (JADER) database. Methods: We identified analyzed reports between April 2004 November 2019 from JADER database calculated reported odds ratios (RORs) disproportionality analysis. Additionally, we relationship related to bendamustine use...
Oxidative stress plays an important role in the pathophysiology of acute kidney injury (AKI). Previously, we reported that vanin-1, which is involved oxidative stress, associated with renal tubular injury. This study was aimed to determine whether urinary vanin-1 a biomarker for early diagnosis AKI two experimental models: vivo and vitro. In rat model AKI, ischemic induced uninephrectomized rats by clamping left artery 45 min then reperfusing kidney. On Day 1 after ischemia/reperfusion...