A5100632598- Quantum Dots Synthesis And Properties
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- vaccines and immunoinformatics approaches
- Carbon and Quantum Dots Applications
- Reproductive System and Pregnancy
- Heat shock proteins research
- Neuroinflammation and Neurodegeneration Mechanisms
- Food Allergy and Anaphylaxis Research
- Chemical and Physical Properties in Aqueous Solutions
- Natural Antidiabetic Agents Studies
- Biosensors and Analytical Detection
- Tryptophan and brain disorders
- Parkinson's Disease Mechanisms and Treatments
- Renal and related cancers
- Neuroscience and Neuropharmacology Research
- Selenium in Biological Systems
- Nanoparticles: synthesis and applications
- Mast cells and histamine
- Immune cells in cancer
- Vitamin C and Antioxidants Research
- Nanocluster Synthesis and Applications
- Nuclear Receptors and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Sperm and Testicular Function
Soochow University
2021-2024
Northwest A&F University
2021-2022
Shenzhen University
2019-2021
Xiamen Medical College
2019-2020
North China University of Science and Technology
2020
Shenzhen University Health Science Center
2018-2019
Shanghai Jiao Tong University
2019
Shanghai First People's Hospital
2019
Jilin University
2016
Jilin Medical University
2012
Although InP/ZnS quantum dots (QDs) have emerged as a presumably less hazardous alternative to cadmium-based QDs, their toxicity has not been fully understood. In this work, we report the cytotoxicity of QDs with different surface groups (NH2, COOH, OH) toward two lung-derived cell lines. The diameter and spectra were characterized hydrodynamic size in aqueous solution was compared. confocal laser scanning microscopy applied visualize labeling for human lung cancer HCC-15 Alveolar type II...
Introduction: Indium phosphide (InP) quantum dots (QDs) have shown a broad application prospect in the fields of biophotonics and nanomedicine. However, potential toxicity InP QDs has not been systematically evaluated. In particular, effects different surface modifications on biodistribution are still unknown, which hinders their further developments. The present study aims to investigate vivo InP/ZnS QDs. Methods: Three kinds with modifications, hQDs (QDs-OH), aQDs (QDs-NH 2 ), cQDs...
Neuroinflammation, as an important pathological characteristic of Parkinson's disease (PD), is primarily mediated by activated astrocytes and microglia. Neuron-restrictive silencer factor/repressor element 1 (RE1)-silencing transcription factor (NRSF/REST) regulates many genes signal pathways involved in the inflammatory process astrocytes. In present study, we established GFAP-Cre:NRSFflox/flox conditional knockout (cKO) mice. The expression inflammation-associated molecules were measured...
In recent years, quantum dots (QDs) have emerged as a potential contrast agent for bioimaging due to their bright luminescence and excellent photostability. However, the wide use of QDs in vivo has been limited underlying toxicity caused by leakage heavy metals. Although non-cadmium developed resolve this issue, comprehensive understanding these newly remains elusive. study, we administered PEGylated copper indium sulfide/zinc sulfide (CuInS2/ZnS), which are typical QDs, analyzed long-term...
Increased applications of quantum dots (QDs) in the biomedical field have aroused attention for their potential toxicological effects. Although numerous studies been carried out on toxicity QDs, effects reproductive and development are still unclear. In this study, we systematically evaluated male developmental CdSe/ZnS QDs BALB/c mice. The mice were injected intravenously with at dosage 2.5 mg/kg BW or 25 BW, respectively, survival status, biodistribution testes, serum sex hormone levels,...
Quantum dots (QDs) are widely used semiconductor nanomaterials. Indium phosphide/zinc sulfide (InP/ZnS) QDs becoming potential alternatives to toxic heavy metal-containing QDs. However, the toxicity and, in particular, immunotoxicity of InP/ZnS unknown. This study aimed investigate impacts on inflammatory responses both vivo and vitro.Mice mouse bone marrow-derived macrophages (BMMs) were exposed polyethylene glycol (PEG) coated The infiltration neutrophils release interleukin-6 (IL-6)...
Lanthanum oxide (La2O3) nanoparticles (NPs) have been widely used in catalytic and photoelectric applications, but the reproductive toxicity is still unclear. This study evaluated of two different-sized La2O3 particles testes.Fifty Kunming mice were randomly divided into five groups. Mice treated with NPs by repeated intragastric administration for 90 days (control, nano-sized 5, 10, 50 mg/kg BW micro-sized BW). control group de-ionised water without NPs. Sperm parameters, testicular...
Purpose:In order to improve the immunogenicity of whole tumor cell lysate for vaccine, we have designed a series CpG ODNs study their transport and evaluate anti-tumor activity in B16 melanoma mouse models.Methods: In this study, investigated whether C-class ODN (CpG ODN-685) could facilitate induce vigorous against tumors mice both prophylactically therapeutically.Results: It was found that combination ODN-685 inhibit growth prolong survival tumor-bearing mice.Moreover with addition can...
InP QDs have shown a great potential as cadmium-free alternatives in biomedical applications. It is essential to understand the biological fate and toxicity of QDs. In this study, we investigated vivo renal InP/ZnS terminated with different functional groups—hydroxyl (hQDs), amino (aQDs) carboxyl (cQDs). After single intravenous injection into BALB/c mice, blood biochemistry, distribution, histopathology, inflammatory response, oxidative stress apoptosis genes were evaluated at predetermined...
Momordica charantia L. (Cucurbitaceae) is rich in saponins, which have multiple biological effects. In this study, the total saponins of M. were extracted by high hydrostatic pressure (HHP) technology. The optimal extraction process was determined (ethanol concentration 68%, pressure-holding time 8 min, ratio material to solvent 1:35 and 510 MPa), amount reached 127.890 mg/g. On basis, an ionic liquid-based aqueous biphasic system constructed purify saponins. Under optimized conditions,...
Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) are extensively applied in biomedical fields, such as magnetic resonance imaging and nanocarriers. However, the biosafety of SPIONs is not completely established, especially their effect on immune system inflammatory responses. Toll‐like receptor (TLR) signaling essential for many acute chronic human diseases. Regulation TLR responses with drugs helpful these conditions. In this study, we investigated effects 10 30 nm macrophages...
Tumor cell lysate (TCL) has an advantage of containing extensive repertoire tumor antigens but requires proper adjuvants to enhance its immunogenicity when used as efficient vaccine. Mycobacterium tuberculosis–derived heat shock protein 70 (TBHsp70) been shown assist crosspresentation exogenously applied and activate innate immunity against cells. In this study, TBHsp70-B16TCL, a preparation generated by mixing recombinant TBHsp70 TCL B16 melanoma cells directly, was tested for The...
Astrocytic senescence is inextricably linked to aging and neurodegenerative disorders, including Parkinson's disease (PD). P7C3 a small, neuroprotective aminopropyl carbazole compound that exhibits anti-inflammatory properties. However, the effects of on astrocytic in PD remain be elucidated.
HER2/neu peptide-based vaccines can eliminate human tumors overexpressing the epidermal growth factor receptor 2 (HER2/neu), but efficacy of this therapeutic strategy is suboptimal. Heat shock proteins (HSPs) are capable eliciting efficient cytotoxic T lymphocyte (CTL) responses by cross-presentation. To evaluate whether immunization with a HSP65–HER2 fusion peptide could selectively HER2+ B16 melanoma cells in xenograft tumor mouse model, was incubated immature dendritic (iDCs) vitro to...
Abstract Background: Indium phosphide (InP) quantum dots (QDs) have shown a broad application prospect in the fields of biophotonics and nanomedicine. However, potential toxicity InP QDs has not been systematically evaluated. In particular, effects different surface modifications on biodistribution is still unknown, which hinders their further developments. The present study aims to investigate vivo three types InP/ZnS with modifications, hQDs (QDs-OH), aQDs (QDs-NH2), cQDs (QDs-COOH)...