A5029794801- Rheumatoid Arthritis Research and Therapies
- Bone health and osteoporosis research
- Genetic and phenotypic traits in livestock
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Bone health and treatments
- Acute Myocardial Infarction Research
- Bone and Joint Diseases
- Autoimmune and Inflammatory Disorders Research
- RNA and protein synthesis mechanisms
- Biosimilars and Bioanalytical Methods
- Monoclonal and Polyclonal Antibodies Research
- Bone Metabolism and Diseases
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- Advanced biosensing and bioanalysis techniques
- Genetics and Plant Breeding
- Protein Structure and Dynamics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Cardiac Imaging and Diagnostics
- Animal Nutrition and Physiology
- Cytokine Signaling Pathways and Interactions
- Attention Deficit Hyperactivity Disorder
- Hip and Femur Fractures
Novartis (Switzerland)
2023
Eli Lilly (United States)
2013-2022
Eli Lilly (Spain)
2014-2020
Sapienza University of Rome
2018
Spanish National Centre for Cardiovascular Research
2006-2015
Hospital Clínico San Carlos
2010-2013
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2013
Johns Hopkins University
2009-2010
Universidad Autónoma de Madrid
2004-2005
Consejo Superior de Investigaciones Científicas
2004-2005
The effect of β-blockers on infarct size when used in conjunction with primary percutaneous coronary intervention is unknown. We hypothesize that metoprolol reduces administered early (intravenously before reperfusion).Patients Killip class II or less anterior ST-segment-elevation myocardial infarction (STEMI) undergoing within 6 hours symptoms onset were randomized to receive intravenous (n=131) not (control, n=139) reperfusion. All patients without contraindications received oral 24 hours....
VCAM-1 and ICAM-1, receptors for leukocyte integrins, are recruited to cell–cell contact sites on the apical membrane of activated endothelial cells. In this study, we show that recruitment is independent ligand engagement, actin cytoskeleton anchorage, heterodimer formation. Instead, ICAM-1 by inclusion within specialized preformed tetraspanin-enriched microdomains, which act as adhesive platforms (EAPs). Using advanced analytical fluorescence techniques, have characterized diffusion...
The circadian clock influences a number of cardiovascular (patho)physiological processes including the incidence acute myocardial infarction. A variation in infarct size has recently been shown rodents, but there is no clinical evidence this finding.To determine impact time-of-day onset ST segment elevation infarction (STEMI) on size.A retrospective single-centre analysis 811 patients with STEMI admitted between 2003 and 2009 was performed. Infarct estimated by peak enzyme release....
The main research tool for identifying microRNAs involved in specific cellular processes is gene expression profiling using microarray technology. Agilent one of the major producers microRNA arrays, and data are commonly analyzed by R functions packages collected Bioconductor project. However, an analytical package that integrates characteristics arrays has been lacking. This report presents new bioinformatic AgiMicroRNA pre-processing differential analysis array data. software implemented...
The 2-year, randomized, double-blind, active-controlled fracture endpoint VERO study included postmenopausal women with established osteoporosis, who had at least 2 moderate or 1 severe baseline vertebral fractures (VFx), and bone mineral density (BMD) T-score ≤-1.5. Patients were treated either s.c. daily teriparatide 20 μg oral weekly risedronate 35 mg. As previously reported, the risk of new VFx clinical (a composite nonvertebral fragility [NVFFx]) was statistically significantly reduced...
MicroRNAs (miRNAs) are 21-24 nucleotide RNA molecules that regulate the translation and stability of target messenger RNAs. Abnormal miRNA expression is a common feature diverse cancers. Several previous studies have classified in pancreatic ductal adenocarcinoma (PDAC), although no uniform pattern dysregulation has emerged. To clarify these findings as well to set stage for detailed functional analyses, we performed global profiling 21 human PDAC cell lines, most extensive panel studied...
Objectives This study investigated the effects of dose step-down in patients with rheumatoid arthritis (RA) who achieved sustained disease control baricitinib 4 mg once a day. Methods Patients completed phase 3 could enter long-term extension (LTE). In LTE, received for ≥15 months and maintained CDAI low activity (LDA) or remission (REM) were blindly randomised to continue taper 2 mg. rescue (to mg) if needed. Efficacy safety assessed through 48 weeks. Results both groups LDA (80% mg; 67%...
The Agilent microRNA microarray platform interrogates each with several copies of distinct oligonucleotide probes and integrates the results into a total gene signal (TGS), using proprietary algorithm that makes use background subtracted signal. TGS can be normalized between arrays, recommendation is either not to normalize or 75th percentile intensity. robust multiarray average (RMA) an alternative method, originally developed obtain summary measure mRNA Affymetrix expression arrays by...
Abstract Background Children in sub-Saharan Africa (SSA) remain the most vulnerable to malaria and mortality. This study estimated disease burden distribution of Plasmodium falciparum among children with age categories (0 < 2 years, 6 12 ≥ years) SSA. Methods Data on number cases incidence rates P. by group from Institute Health Metrics Evaluation (GBD 2019) for 11 countries SSA was employed this study. The best-fitting prespecified derived using a combination Log-normal Weibull...
The aim of this study was to evaluate, the existence a signature differentially expressed microRNAs (miRNAs) during osteogenic differentiation bone marrow MSCs from OA and healthy donors describe their possible implication in joint regeneration through modulation molecular mechanisms involved homeostatic control pathophysiology. Following phenotypic assessment BM-MSCs obtained diagnosed patients (n = 10) non-OA 10), total small RNA isolated after induction for 1, 10 21 days, miRNA profiles...
The onset of inadequate behaviors leading to the development risk factors for chronic diseases is known occur early in life. An effective program health promotion should therefore focus on children and their environment, as starting point behavior development. overarching objective Program SI! (Salud Integral - Comprehensive Health) intervene at school level, establish develop life-lasting habits that will help preserving during adulthood. comprises five consecutive subprograms according...
To elucidate disease-specific molecular changes occurring in osteoarthritis (OA) by analysing the differential gene expression profiles of bone marrow mesenchymal stem cells (BM-MSCs) from patients with OA compared those without OA.Expression BM-MSCs eight paired and hip fracture signs were DNA microarray analysis significant differences evaluated computational Gene Set Enrichment Analysis. validate involvement COL10A1 as part most downregulated set OA, three tagging single nucleotide...
The objective of this study was to evaluate structural damage progression based on clinical response in rheumatoid arthritis patients with no or limited prior disease-modifying anti-rheumatic drug treatment receiving the Janus kinase (JAK)1/JAK2 inhibitor baricitinib 4 mg, methotrexate (MTX), combination. Data from phase 3 RA-BEGIN were analysed post hoc. Proportions (change baseline greater than smallest detectable change modified total Sharp score) at week 52 evaluated sustained Disease...
Two types of mutations may lead to deficient pre-mRNA splicing: cis-acting that inactivate a constitutive or alternative splice site within the pre-mRNA, and trans-acting affect function basal factor splicing machinery. Autosomal dominant retinitis pigmentosa (adRP) is caused by in at least 12 genes, with rhodopsin being most prevalent. mutations, g.3811A>G g.5167G>T gene (RHO; GenBank U49742.1) are linked adRP Spanish population; while mutation, g.4335G>T, has been recessive RP (arRP)....