A5100349341- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Analytical Chemistry and Chromatography
- Gut microbiota and health
- Phytochemical and Pharmacological Studies
- Wastewater Treatment and Nitrogen Removal
- Food Quality and Safety Studies
- Medicinal Plants and Neuroprotection
- Phytochemistry and Biological Activities
- Neurological Disease Mechanisms and Treatments
- Microbial Fuel Cells and Bioremediation
- Plant-based Medicinal Research
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Rice Cultivation and Yield Improvement
- Heavy metals in environment
- Healthcare and Venom Research
- Ammonia Synthesis and Nitrogen Reduction
- Advanced Proteomics Techniques and Applications
- Spectroscopy and Chemometric Analyses
- Kruppel-like factors research
- Arsenic contamination and mitigation
Shanghai University of Traditional Chinese Medicine
2020-2024
China Pharmaceutical University
2022-2024
Nanjing Agricultural University
2024
Northeast Agricultural University
2023-2024
Hunan University of Humanities, Science and Technology
2023-2024
Yangtze University
2024
Nanjing Traditional Chinese Medicine Hospital
2023
Shanghai Eighth People Hospital
2017-2023
Southwest University
2023
Dalian University
2023
The identification of molecules within complex mixtures is a major bottleneck in natural products (NPs) research. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has emerged as the main tool for high-throughput characterization NPs. large amount data sets by LC-MS/MS presents challenge processing and interpretation, molecular network (MN) one most prominent tools analyzing MS/MS sets, widely used rapid classification, identification, structural speculation unknown compounds....
Excessive heavy metal content in soil can seriously hinder plant physiological metabolism and growth. This study, with soybean, examined how drip irrigation reduced toxicity. The experiments four frequencies were conducted by controlling the lower limit of matric potential (D1: −10 kPa; D2: −20 D3: −30 D4: −40 kPa). Through comparison traditional surface irrigation, effects on distribution, soybean growth status, transcriptome under Cd, Pb Cr(VI) composite pollution comprehensively analyzed....
Background and Purpose— There have been no multicity studies on the acute effects of air pollution stroke mortality in China. This study was undertaken to examine associations between daily outdoor (particulate matter <10 μm aerodynamic diameter, sulfur dioxide, nitrogen dioxide) 8 Chinese cities. Methods— We used Poisson regression models with natural spline-smoothing functions adjust for long-term seasonal trends, as well other time-varying covariates. applied 2-stage Bayesian...
Copious evidence demonstrates the crucial role of Rho GTPase-activating proteins in human malignancies. The downregulation protein 15 (ARHGAP15), a Rac1-specific GAP, has been observed glioma and pancreatic ductal adenocarcinoma. present study explored expression colorectal cancer (CRC) by quantitative real-time PCR immunohistochemistry analysis. possible function ARHGAP15 CRC was investegated vitro vivo. We found that obviously lower specimens than normal colonic mucosa. significantly...
Current studies have shown that gut microbiota may be closely related to the severity of coronavirus disease 2019 (COVID-19) by regulating host immune response. Qing-Fei-Pai-Du decoction (QFPDD) is recommended drug for clinical treatment patients with COVID-19 in China, but whether it exerts a therapeutic effect modulating response through remains unclear. In this study, we evaluated effects QFPDD pneumonia model mice and performed 16S rRNA sequencing serum lung tissue metabolomic analysis...
Metabolomics based on high-resolution mass spectrometry has become a powerful technique in biomedical research. The development of various analytical tools and online libraries promoted the identification biomarkers. However, how to make collect more data information is an important but underestimated research topic. Herein, we combined full-scan data-dependent acquisition (DDA) modes develop new targeted DDA inclusion list differential preidentified ions (dpDDA). In this workflow, MS1...
Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline catalyzed by deiminase (PADs), has been confirmed as a unique form posttranslational modification proteins. Among five isoforms PADs, PAD2 is main PAD enzyme expressed in central nervous system (CNS). Previous studies reported that citrullinated proteins was increasingly associated with neurological disorders such Alzheimer's disease, prion disease and Multiple Sclerosis. However, physiological role CNS are...
We synthesized a series of the novel deep blue light-emitting polymers (PF-4,6SOs) by combination fluorene-2,7-diyl and dibenzothiophene-S,S-dioxide-4,6-diyl (4,6SO). PF-4,6SOs demonstrated excellent solubility high thermal stability. The introduction...
Soil heavy metal pollution seriously endangers the soil ecological environment and food safety production. In this study, drip irrigation tests with four frequencies were conducted by controlling lower limit of matric potential (D1: −10 kPa; D2: −20 D3: −30 D4: −40 kPa). Through comparison traditional surface irrigation, effect on root zone under mechanism through which influences soybean enrichment characteristics explored. The conclusions are as follows. (i) Drip can improve combined Cd,...
Background/Aims: A few Rho GTPase activating proteins (RhoGAPs) have been identified as tumor suppressors in a variety of human cancers. ARHGAP17, member RhoGAPs, has reported to be involved the maintenance tight junction and epithelial barrier. The present study aimed explore its expression colon cancer possible function colonic carcinogenesis. Methods: mRNA protein was assessed by realtime PCR immunoblotting, respectively. Cell Counting Kit-8 (CCK-8) Transwell assays were performed...
Abstract Discovering marker components of traditional Chinese medicine formulas is challenging because the hundreds they inherently contain. This study first proposed a reliable and validated method for comprehensive profiling chemical constituents in Honghua Xiaoyao tablet by using high‐performance liquid chromatography coupled with mass spectrometry. After searching within in‐house library, total 55 were unambiguously characterized or tentatively identified through reference standards...