A5100626351- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Eicosanoids and Hypertension Pharmacology
- Cervical Cancer and HPV Research
- Multiple Myeloma Research and Treatments
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Cardiac Ischemia and Reperfusion
- Neurological Disease Mechanisms and Treatments
- Signaling Pathways in Disease
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Traditional Chinese Medicine Analysis
- Peptidase Inhibition and Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Viral Infections and Vectors
- Immune cells in cancer
- Eosinophilic Esophagitis
- Ovarian cancer diagnosis and treatment
- Cancer Diagnosis and Treatment
- Immune Response and Inflammation
- Cardiac Fibrosis and Remodeling
- Kawasaki Disease and Coronary Complications
Dongguan People’s Hospital
2024
Chinese University of Hong Kong
2024
Beijing Anzhen Hospital
2013-2023
Capital Medical University
2013-2023
Tsinghua University
2021-2023
Beijing Chuiyangliu Hospital
2023
State Council of the People's Republic of China
2021
Second Military Medical University
2007-2021
Beijing Chao-Yang Hospital
2021
ShenZhen People’s Hospital
2020
Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of IIA, well-known Chinese medicine for treating cardiovascular disorders. Cardiomyocyte apoptosis plays major role in the development diseases. The present study was designed to investigate effects STS on cardiomyocyte induced by vivo acute myocardial infarction (MI) adult rats and vitro H2O2-treated neonatal rat ventricular myocytes. In MI rats, significantly reduced infarct sizes, blood lactate dehydrogenase (LDH) level,...
Purpose: We aimed to investigate potential synergistic antiplatelet effects of Ginkgo biloba extract (GBE50) in combination with aspirin using vitro models. Methods: Arachidonic acid (AA), platelet activating factor (PAF), adenosine 5ʹ-diphosphate (ADP) and collagen were used as inducers. The GBE50, 1:1 GBE50 detected by microplate method rabbit platelets. Synergy finder 2.0 was analyze the effect. compounds identified UPLC-Q/TOF-MS analysis candidate screened TCMSP database. targets...
Background: Lynch Syndrome (LS) is an autosomal dominant disease characterized by germline heterozygous mutations in DNA mismatch repair (MMR) genes. High-risk LS patients may proceed to colorectal cancer (CRC). However, the drivers or biomarkers of benign colon tissue approaching malignant CRC are not completely understood. The similarity and difference between LS-related nonLS-related also well interrogated (LS-CRC vs. nonLS-CRC). This study aimed understand cellular changes during...
Arterial baroreflex is one of the most important mechanisms in regulation cardiovascular activities. function can be expressed as sensitivity (BRS). The present study was designed to test 2 hypotheses: (1) BRS a new independent predictor for incidence stroke hypertension, and (2) restoration prevent hypertension.First, 82 stroke-prone spontaneously hypertensive rats (SHR-SP) aged 28 30 weeks were used. After measuring blood pressure BRS, survival time observed. Second, 12 SHR-SP 8 months...
Qi-Jing-Sheng-Bai granule (QJSB) is a new developed traditional Chinese medicine (TCM) formula. In clinical, it has been used for the treatment of leucopenia. However, therapeutic mechanism needs further solid investigation. present study, we first tested effect QJSB on leucopenia mice induced by cyclophosphamide with administration to 8 days. Our experiments showed that significantly increased number peripheral white blood cells, platelets and nucleated bone marrow cells. Meanwhile markedly...
Background An inflammatory response leading to organ dysfunction and failure continues be a major problem after injury in many clinical conditions such as sepsis, severe burns, trauma. It is increasingly recognized that atrial natriuretic peptide (ANP) possesses broad range of biological activities, including effects on endothelial function inflammation. A recent study has revealed ANP exerts anti-inflammatory effects. In this we tested the human (hANP) lung model oleic acid (OA)-induced...
Succinate is an intermediate of the citric acid cycle and serves important functions in energy homeostasis metabolic regulation. Extracellular accumulation succinate acts as a stress-induced signal through its G protein-coupled receptor, SUCNR1. Research on signaling hampered by lack high-resolution structures agonist-bound receptor. Here we present cryo-EM SUCNR1-Gi complexes with receptor bound to non-metabolite derivative epoxysuccinate. Structural analysis SUCNR1 identified key...
Helicobacter pylori infection is a significant burden to the public health in China as it can lead various gastric diseases including peptic ulcers and cancer. Since most infections occurred during childhood, therefore necessary understand prevalence risk determinants of this bacterial children. Herewith, we conducted cross-sectional study Kuichong Subdistrict Shenzhen City assess factors H. among children.From September 2018 October 2018, 1,355 children aged 6-12 years from four primary...
Arterial baroreflex (ABR) function is an important determinant factor in prognosis of many cardiovascular diseases. The present work was designed to study the relationship between ABR and survival time septic shock a cecal ligation puncture (CLP) rat model. dysfunction introduced by sinoaortic denervation (SAD). It found that after CLP significantly reduced SAD rats compared with sham-operated (12.7 ± 2.92 hours versus 15.0 4.01 hours; P < 0.05). Furthermore, significant differences were...
The current light transmission aggregation method is a recognized conventional for platelet function evaluation, but it time-consuming and poor in parallelism cannot simultaneously monitor multiple inducers at levels. microtiter plate has been established because of the high-throughput characteristic, needs more practical applications.To evaluate by using aspirin clopidogrel vivo vitro.In vitro, aggregations inhibited (0.3, 1, 3, 10, 30, 90 μM) (1, 100, 300 were evaluated with presence...
This study was designed to investigate the effects of telmisartan and amlodipine on reduction blood pressure (BP), myocardial hypertrophy, renal injury in hypertensive rats.In acute experiments, BP measured conscious freely moving rats. Spontaneously rats were treated with intragastric administration (1, 2, 4 mg/kg), (4, 8, 12, 16, 20 their different combinations (4 + 4, 2 1 20, mg/kg). The probability sum test (q test) used evaluate synergistic action reduction. In two-kidney, one-clip...
This study aimed to identify the clinical significance of TP53 and common cytogenetic abnormalities.A total 114 patients with newly diagnosed multiple myeloma (MM) abnormalities were selected from two large patient cohorts collaborating hospitals 2010 2017. The characteristics outcomes these analyzed. other mutations in MM quantified by fluorescence situ hybridization. Kaplan-Meier curves log-rank tests applied for survival analysis. A Cox proportional hazard model covariate analysis was...
Objective: The size and morphology of the right ventricular outflow tract (RVOT) in patients suffering from long-term pulmonary regurgitation (PR) after native RVOT (NRVOT) reconstruction are important factors affecting feasibility, safety, effectiveness transcatheter valve replacement. purpose this study was to evaluate a transthoracic Salus (Balance Medical Technology Co., Ltd, Beijing, China) with moderate-to-severe PR NRVOT reconstruction. Methods: Patients were selected between June...