A5048083087- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA Research and Splicing
- Hippo pathway signaling and YAP/TAZ
- Ubiquitin and proteasome pathways
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Microtubule and mitosis dynamics
- Cancer Genomics and Diagnostics
- Pharmacogenetics and Drug Metabolism
- Intraperitoneal and Appendiceal Malignancies
- RNA Interference and Gene Delivery
- Sarcoma Diagnosis and Treatment
- Cancer Research and Treatments
- Endometriosis Research and Treatment
- Cancer Cells and Metastasis
- Chemical Reactions and Isotopes
- Occupational and environmental lung diseases
- Wnt/β-catenin signaling in development and cancer
- Metastasis and carcinoma case studies
- Histone Deacetylase Inhibitors Research
- Digestive system and related health
- Cholangiocarcinoma and Gallbladder Cancer Studies
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2025
National Cancer Institute
2023-2024
Istituti Fisioterapici Ospitalieri
2023
Instituto Nazionale Tumori Regina Elena
2012
Tumori Foundation
2012
Micro RNAs (miRs) are small non-coding aberrantly expressed in human tumors. Here, we aim to identify miRs whose deregulated expression leads the activation of oncogenic pathways gastric cancers (GCs). Thirty nine out 123 tumoral and matched uninvolved peritumoral specimens from three independent European subsets patients were analyzed for 851 using Agilent Platform. The remaining 84 samples used validate differentially between by qPCR. miR-204 falls into a group eight samples....
Abstract Sperm-associated antigen 5 (SPAG5) is an important driver of the cell mitotic spindle required for chromosome segregation and progression into anaphase. SPAG5 has been identified as proliferation marker chemotherapy-sensitivity predictor, especially in estrogen receptor-negative breast cancer subtypes. Here, we report that a direct target miR-10b-3p, its aberrantly high expression associates with poor disease-free survival two large cohorts patients. depletion strongly impaired...
Triple negative breast cancer (TNBC) is an aggressive disease which currently has no effective therapeutic targets and prominent biomarkers. The Sperm Associated antigen 5 (SPAG5) a mitotic spindle associated protein with oncogenic function in several human cancers. In TNBC, increased SPAG5 expression been tumor progression, chemoresistance, relapse, poor clinical outcome. Here we show that high TNBC regulated by coordinated activity of YAP, mutant p53 MYC. Depletion YAP or proteins reduced...
Abstract Background Altered metabolism is one of the cancer hallmarks. The role circRNAs in poorly studied. Specifically, impact circPVT1, a well-known oncogenic circRNA on triple negative breast mechanistically underexplored. Methods clinical significance circPVT1 expression levels was assessed human samples using digital PCR and genome atlas (TCGA) dataset. activity TNBC cell lines MCF-10 A line by either ectopic or depletion molecule. CircPVT1 mediated metabolic perturbation 1 H-NMR...
There is high need of novel diagnostic and prognostic tools for tumors the digestive system, such as gastric cancer cholangiocarcinoma. We recently found that miR-204 was deeply downregulated in tissues. Here we investigated whether this common to other system elicited a miR-204-dependent gene target signature, diagnostically therapeutically relevant. Finally, assessed contribution identified genes cell cycle progression clonogenicity cholangiocarcinoma lines.We employed quantitative PCR...
// Federica Mori 1 , Andrea Sacconi 2 Valeria Canu Ganci Mariangela Novello 3 Vincenzo Anelli 4 Renato Covello 5 Virginia Ferraresi 6 Paola Muti 7 Roberto Biagini 8 Giovanni Blandino 2,7 and Sabrina Strano 1,7 Molecular Chemoprevention Unit, Regina Elena National Cancer Institute, Rome, Italy Translational Oncogenomics, Department of Pathology, Catholic University, UOC Radiology, Medical Oncology A, Oncology, McMaster Hamilton, ON, Canada Orthopedic Surgery, Correspondence: Blandino, email:...
Approximately 20-50% of patients presenting with localized colorectal cancer progress to stage IV metastatic disease (mCRC) following initial treatment and this is a major prognostic determinant. Here, we have interrogated heterogeneous set primary (CRC), liver CRC metastases adjacent tissue identify molecular determinants the colon spreading. Screening Food Drug Administration (FDA) approved drugs for their ability interfere an identified metastasis signature may help filling unmet...
Metastasis is a leading cause of cancer-related deaths, yet understanding how metastatic tumors adapt from their origin to target tissues remains fundamental challenge. To address this, we assessed whether primary and more closely resemble or in terms gene expression. We analyzed expression profiles multiple cancer types normal tissues, including single-cell bulk RNA sequencing data both paired unpaired patient cohorts. Primary were overall transcriptomically similar origin, while metastases...
Hyperthermic intraperitoneal administration of chemotherapy (HIPEC) increases local drug concentrations and reduces systemic side effects associated with prolonged adjuvant exposure in patients affected by either peritoneal malignancies or metastatic diseases originating from gastric, colon, kidney, ovarian primary tumors. Mechanistically, the anticancer HIPEC have been poorly explored. Herein we documented that treatment promoted miR-145-5p expression paired a significant downregulation its...
Metastasis is a leading cause of cancer-related deaths, yet understanding how metastatic tumors adapt from their origin to target tissues challenging. To address this, we assessed whether primary and resemble tissue or in terms gene expression. We analyzed expression profiles various cancer types, including single-cell bulk RNA-seq data, both paired unpaired patient cohorts. quantified the transcriptomic distances between tumor samples normal tissues, revealing that are more similar origin,...
Background and Objectives Gastric cancers are usually characterized using Lauren's classification into intestinal diffuse types. We previously documented the down‐modulation of miR31, miR148a, miR204, miR375 in gastric cancers. aimed this manuscript to investigate these miRs with end‐points diagnosis, prognosis. Methods A total 117 resected non‐cardial adenocarcinomas were evaluated for miRs' expressions. The performance miRs’ expressions cancer diagnosis was tested ROC curves. Logistic...
<title>Abstract</title> Triple negative breast cancer (TNBC) is an aggressive disease which currently has no effective therapeutic targets and prominent biomarkers. The Sperm Associated antigen 5 (SPAG5) a mitotic spindle associated protein with oncogenic function in several human cancers. In TNBC, increased SPAG5 expression been tumor progression, chemoresistance, relapse, poor clinical outcome. Here we show that high TNBC regulated by coordinated activity of YAP, mutant p53 MYC. Depletion...