A5057614065- Osteoarthritis Treatment and Mechanisms
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Natural product bioactivities and synthesis
- Medical Imaging and Pathology Studies
- Bone and Joint Diseases
- Bone fractures and treatments
- Peptidase Inhibition and Analysis
- Orthopedic Surgery and Rehabilitation
- Bone health and osteoporosis research
- Hip and Femur Fractures
- Folate and B Vitamins Research
- Hepatitis C virus research
- Multiple Myeloma Research and Treatments
- Bone health and treatments
- Cancer Mechanisms and Therapy
- Urinary Bladder and Prostate Research
- Selenium in Biological Systems
- Chronic Lymphocytic Leukemia Research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
Nanjing Medical University
2014-2023
Beijing Luhe Hospital Affiliated to Capital Medical University
2017-2022
Nanjing Drum Tower Hospital
2015-2022
First Hospital of China Medical University
2020
China Medical University
2010-2020
Fujian Agriculture and Forestry University
2017
Nanjing University
2014-2015
Philipps University of Marburg
2005
Moso bamboo (Phyllostachys edulis) represents one of the fastest-spreading plants in world, due part to its well-developed rhizome system. However, post-transcriptional mechanism for development system has not been comprehensively studied. We therefore used a combination single-molecule long-read sequencing technology and polyadenylation site (PAS-seq) re-annotate genome, identify genome-wide alternative splicing (AS) (APA) In total, 145 522 mapped full-length non-chimeric (FLNC) reads were...
Plant cryptochromes undergo blue light-dependent phosphorylation to regulate their activity and abundance, but the protein kinases that phosphorylate plant have remained unclear. Here we show photoexcited Arabidopsis cryptochrome 2 (CRY2) is phosphorylated in vivo on as many 24 different residues, including 7 major phosphoserines. We demonstrate four closely related Photoregulatory Protein Kinases (previously referred MUT9-like kinases) interact with CRY2. Analyses of ppk123 ppk124 triple...
Osteoarthritis (OA), the commonest arthritis type, features irreversible cartilage loss and synovitis. It was reported that macrophages have an important function in synovial inflammation, our team revealed amounts of Sirt6, a nicotinamide adenine dinucleotide (NAD)+-dependent histone deacetylase, decrease during inflammation osteoarthritis. This work aimed to examine anti-inflammatory properties Sirt6 inflammation. Firstly, we compared acute meniscus injury OA human knee tissue samples by...
The aim of the present study was to investigate effect 7,8‑dihydroxyflavone (7,8‑DHF) against osteoarthritis (OA) and examine its regulatory role in nuclear factor (erythroid‑derived 2)‑like 2 (Nrf2) signaling pathway chondrocytes. Primary mouse chondrocytes were treated with 7,8‑DHF expression Nrf2 downstream heme oxygenase 1 (HO‑1). surgical destabilization medial meniscus model used assess effectiveness protecting cartilage from damage, knee harvested mice for histological analysis....
Aims: The pathogenesis of osteoarthritis (OA) is characterized by oxidative stress (OS) and sustained inflammation that are substantially associated with epigenetic DNA methylation alterations osteogenic gene expression. Diacerein as an anthraquinone anti-OA drug exhibits multiple chondroprotective properties, but less clarified pharmacological actions. Since contain modulating property, in this study we investigate whether the functions diacerein involve modulation antioxidant signaling....
BACKGROUND Circular RNAs (circRNAs) have emerged as important regulators in carcinogenesis and metastasis. However, the knowledge of circRNAs bladder cancer remains limited. This study aimed to investigate role mechanism development progression cancer. MATERIAL AND METHODS Three pairs carcinomas (including high- low-grade tumors) adjacent normal tissues were collected from patients. The total extracted these samples subjected Clariom D microarray assays detect differentially expressed mRNAs....
Sinapic acid (SA) modulates the nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling pathway in chondrocytes. In order to test hypothesis that SA is protective against development of osteoarthritis (OA), primary mouse chondrocytes were treated vitro with and promoter transactivation activity heme oxygenase 1 (HO-1), translocation Nrf2, protein expression HO-1 assayed. To vivo , a destabilization medial meniscus (DMM) model was used induce OA knees mice delivered orally experimental...
The aim of the present study was to investigate a novel technology, requiring only single portal and no special equipment, perform endoscopic treatment carpal tunnel (CT) syndrome (CTS). This technique involves surgical approach standard operating procedures is designed minimize potential for complications. Patients with CTS were randomly assigned using computer‑generated random allocation stratified by site either modified CT release (MECTR) group (n=48) or open (OCTR) (n=46). Various...
Osteoarthritis (OA) is a common joint disorder characterized by progressive articular cartilage degeneration and destruction results in gradual disability among middle‑aged elderly patients. Our previous study demonstrated that depletion of nuclear factor erythroid 2‑related 2 (Nrf2) exacerbated erosion an OA model activation the Nrf2 pathway could counter this process. As downstream target Nrf2, heme oxygenase (HO) degrades to free iron, biliverdin carbon monoxide (CO), which protects...
BACKGROUND:miRNAs have been widely used in cancer treatment. Our study was designed to explore the effects of miR-325-3p bladder cells. MATERIAL AND METHODS:Levels ofd and MT3 tissues cells were assessed by quantitative real-time polymerase chain reaction (qRT-PCR). mimics transfected into T24 cells, cell migration invasion rates proliferation transwell assay Cell Counting Kit-8 (CCK-8). The target mRNA for predicted Targetscan7.2 confirmed dual-luciferase reporter assay. More experiments...
Osteoarthritis (OA) is the most prevalent joint disorder characterized by progressive cartilage damage, resulting in gradual disability among elderly. We previously provided <em>in vivo</em> evidence that nuclear factor erythroid 2‑related 2 (Nrf2) deficiency associated with development of OA. It has been reported coniferaldehyde (CFA) acts as a potential Nrf2 activator. The aim present study was to investigate protective effects CFA against osteoarthritis. A murine model surgical‑induced OA...
Osteoarthritis is a common degenerative disease linked with inflammatory disorders and oxidative stress. Glabridin an isoflavonoid major active constituent of licorice. This study aims to investigate the anti-arthritic effects glabridin on nuclear factor erythroid 2 – related (Nrf2) signaling pathway, responses, cartilage degeneration in in-vitro in-vivo models. Studies IL-1β-induced chondrocyte model was performed evaluate matrix metalloproteinase (MMP), Nrf2 pathway. orally administered...
Background: Bladder urothelial carcinoma (BLCA) is a common malignant tumor with the greatest recurrence rate of any solid tumor. Hypoxia crucial in growth and immune escape tumors. To predict clinical outcomes immunological microenvironment patients BLCA, hypoxia-related long non-coding RNA (HRlncRNA) signature was established. Methods: The Cancer Genome Atlas (TCGA) provided us differentially expressed profile HRlncRNAs as well data from we used weighted gene co-expression network analysis...