A5016601952- Advanced biosensing and bioanalysis techniques
- Memory and Neural Mechanisms
- Chemical Synthesis and Analysis
- Muscle Physiology and Disorders
- Neuroscience and Neuropharmacology Research
- Radical Photochemical Reactions
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Photoreceptor and optogenetics research
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- RNA and protein synthesis mechanisms
- Genetic Neurodegenerative Diseases
- Inflammatory Myopathies and Dermatomyositis
- Asthma and respiratory diseases
- Nicotinic Acetylcholine Receptors Study
- Exercise and Physiological Responses
- Stress Responses and Cortisol
- Inflammatory Bowel Disease
- Natural Compounds in Disease Treatment
- Signaling Pathways in Disease
- Bone Metabolism and Diseases
Scripps Research Institute
2014-2022
University of California, San Diego
2019-2022
Scripps Institution of Oceanography
2019
Torrey Pines Institute For Molecular Studies
2019
Scripps (United States)
2019
Children's National
2012-2016
Kellogg's (Canada)
2014
ReveraGen BioPharma (United States)
2012-2013
University at Buffalo, State University of New York
2012
George Washington University
2012
Absence of dystrophin makes skeletal muscle more susceptible to injury, resulting in breaches the plasma membrane and chronic inflammation Duchenne muscular dystrophy (DMD).Current management by glucocorticoids has unclear molecular benefits harsh side effects.It is uncertain whether therapies that avoid hormonal stunting growth development, and/or immunosuppression, would be or less beneficial.Here, we discover an oral drug with mechanisms provide efficacy through anti-inflammatory...
DNA Encoded Libraries have proven immensely powerful tools for lead identification. The ability to screen billions of compounds at once has spurred increasing interest in DEL development and utilization. Although provides access libraries unprecedented size diversity, the idiosyncratic hydrophilic nature tag severely limits scope applicable chemistries. It is known that biomacromolecules can be reversibly, noncovalently adsorbed eluted from solid supports, this phenomenon been utilized...
Glucocorticoids are standard of care for many inflammatory conditions, but chronic use is associated with a broad array side effects. This has led to search dissociative glucocorticoids--drugs able retain or improve efficacy transrepression [nuclear factor-κB (NF-κB) inhibition] the loss effects transactivation (receptor-mediated transcriptional activation through glucocorticoid response element gene promoter elements). We investigated derivative Δ-9,11 modification as steroid. The analog...
Objective Myositis is characterized by severe muscle weakness. We and others have previously shown that endoplasmic reticulum (ER) stress plays a role in the pathogenesis of myositis. The present study was undertaken to identify perturbed pathways assess their contribution disease mouse myositis model. Methods Stable isotope labeling with amino acids cell culture (SILAC) used alterations skeletal proteome myositic mice vivo. Differentially altered protein levels identified initial...
Asthma is a chronic inflammatory condition of the lower respiratory tract associated with airway hyperreactivity and mucus obstruction in which majority cases are due to an allergic response environmental allergens. Glucocorticoids such as prednisone have been standard treatment for many diseases past 60 years. However, despite their effectiveness, long-term often limited by adverse side effects believed be caused glucocorticoid receptor-mediated gene transcription. This has led pursuit...
Abstract The stabilization or consolidation of long-term memories lasting more than a few hours requires new gene expression. While neural activity has been shown to induce expression variety genes within several learning, whether this leads persistent changes in that lasts for days weeks remains unclear. We developed novel mouse line which expresses Cre recombinase an inducible manner and used it examine learning-activated neurons the medial prefrontal cortex (mPFC) one month following...
Abstract The nature and distribution of the synaptic changes that underlie memory are not well understood. We examined plasticity behind context fear conditioning found learning produced potentiation specifically onto engram neurons in basolateral amygdala. This lasted at least 7 days, was reversed by extinction, its disruption impaired recall. High frequency optogenetic stimulation CS US-activated ensembles, or biochemical induction US-responsive alone, sufficient to produce a association...
Herein, we present the adaptation of reversible adsorption to solid support (RASS) for a DEL setting, which allows reactions be performed in organic solvents at near anhydrous conditions opening previously inaccessible chemical reactivities DEL. The RASS approach enabled rapid development C(sp<sup>2</sup>)-C(sp<sup>3</sup>) decarboxylative cross-couplings with broad substrate scope, an electrochemical amination (the first synthetic transformation context), and...
Herein, we present the adaptation of reversible adsorption to solid support (RASS) for a DEL setting, which allows reactions be performed in organic solvents at near anhydrous conditions opening previously inaccessible chemical reactivities DEL. The RASS approach enabled rapid development C(sp 2 )-C(sp 3 ) decarboxylative cross-couplings with broad substrate scope, an electrochemical amination (the first synthetic transformation context), and improved reductive conditions. We believe that...