Miriam Freundt

ORCID: 0000-0001-9189-5759
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About
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Research Areas
  • Mechanical Circulatory Support Devices
  • Cardiac Structural Anomalies and Repair
  • Cardiac Arrest and Resuscitation
  • Transplantation: Methods and Outcomes
  • Aortic Disease and Treatment Approaches
  • Cardiac Valve Diseases and Treatments
  • Congenital Heart Disease Studies
  • Cardiac and Coronary Surgery Techniques
  • Cardiac, Anesthesia and Surgical Outcomes
  • Respiratory Support and Mechanisms
  • Spine and Intervertebral Disc Pathology
  • Blood transfusion and management
  • Anesthesia and Pain Management
  • Erythropoietin and Anemia Treatment
  • Analytical Methods in Pharmaceuticals
  • Muscle and Compartmental Disorders
  • Hip and Femur Fractures
  • Cardiac Fibrosis and Remodeling
  • Cardiomyopathy and Myosin Studies
  • Atrial Fibrillation Management and Outcomes
  • Spinal Hematomas and Complications
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Coronary Artery Anomalies
  • Hormonal and reproductive studies
  • Cardiovascular Issues in Pregnancy

Penn State Milton S. Hershey Medical Center
2021-2025

Christ Hospital
2023-2025

Health Net
2025

International Society for Heart and Lung Transplantation
2024

IFC Research (United Kingdom)
2024

Christ Hospital
2023

Pennsylvania State University
2022

University Hospital Regensburg
2014-2017

Freund (Japan)
2016

Miriam (Norway)
2016

Aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or COVID-19, infection resulting in distress (ARDS) requiring veno-venous veno-arterial extracorporeal membrane oxygenation (VV VA-ECMO) support is a life-threatening disease process that requires prolonged intubation and has high risk of mortality. Methods: In this retrospective, observational, single-center cohort study, we attempt to better understand the role extubation course treatment by dichotomizing groups into those...

10.37349/ec.2025.101249 article EN cc-by 2025-02-05

Background/Aim: Cervical selective nerve root block (CSNRB) is a widely used percutaneous procedure to diagnose and treat cervical radicular pain. The feasibility of three-dimensional puncture planning two-dimensional laser-guidance system has previously been shown in an <i>ex vivo</i> model. purpose this study was further compare technique the conventional computed tomography (CT-)-guided approach. Materials Methods: Thirty CSNRBs were performed, each with Dyna-CT Syngo iGuide<sup>®</sup>...

10.21873/invivo.13875 article EN In Vivo 2025-02-26

Aims Veno-arterial extracorporeal life support (ECLS) is an established method to stabilize acute circulatory failure. Parameters and data on when ideally wean are limited. Bilirubin a marker of end-organ damage. Therefore, the purpose this large study was evaluate impact dynamic changes elevated bilirubin levels survival in patients ECLS. Methods results We reviewed 502 consecutive cases ECLS from 2007 2015. were recorded before implantation until six days after explantation. Dynamic...

10.1371/journal.pone.0184995 article EN cc-by PLoS ONE 2017-10-19

Advanced age is a known risk factor for morbidity and mortality after coronary artery bypass grafting (CABG). Minimized extracorporeal circulation (MECC) has been shown to reduce the negative effects associated with conventional (CECC). This trial assesses impact of MECC on outcome elderly patients undergoing CABG. Eight hundred seventy-five (mean 78.35 years) underwent isolated CABG using CECC (n=345) or (n=530). The group had significantly shorter time (ECCT), cross-clamp reperfusion lower...

10.1177/0267659115588634 article EN Perfusion 2015-06-01

Objectives: Cardiogenic shock [CS] is associated with a high-mortality. Suitable patients maybe successfully bridged using newer intravascular micro-axial left-ventricular assist devices [M-LVAD] for recovery or determination of definitive therapy. Methods: Between January-2020 and July-2024, 107 underwent placement M-LVAD CS. The cohort was divided into 4 groups based on their destination; group-1: 34 [32%] receiving transplant; group-2: 25 [23%] durable LVAD; group-3: 42 [39%] bridging...

10.20944/preprints202410.1254.v1 preprint EN 2024-10-16

Cervical selective nerve root block (CSNRB) is a well-established, minimally invasive procedure to treat radicular cervical pain. However, the technically challenging and might lead major complications. The objective of this study was evaluate feasibility three-dimensional puncture planning two-dimensional laser-guidance system for CSNRB in an ex-vivo model.Dyna-CT spine lamb model performed with Artis Zee® Ceiling (Siemens Medical Solutions, Erlangen, Germany) acquire multiplanar...

10.1371/journal.pone.0069311 article EN cc-by PLoS ONE 2013-07-19

Epicardial ablation concomitant to cardiac surgery is an easy and safe approach treat atrial fibrillation (AF), but its efficacy in longstanding persistent (LsPe) AF remains intermediate. Although larger left size has been associated with worse outcome after ablation, biochemical predictors of success are not well established. The aim this study was evaluate relationship between marker, echo-characteristic rhythm 6 months follow-up epicardial ultrasound (HIFU) ablation. We included 78...

10.1186/1749-8090-8-218 article EN cc-by Journal of Cardiothoracic Surgery 2013-11-28

Abstract Background Historically, female patients had worse outcome undergoing heart surgery. No recent data exist on gender-specific after moderate hypothermic circulatory arrest (MHCA). The aim of this large retrospective analysis was to investigate gender disparity in elective surgery ascending aorta MHCA at 24°C. Methods We conducted a review 905 (33.3% female) cases for aortic aneurysm (90.9%) or severely calcified (12.5%) between 2001 and 2015. Furthermore, 299 male matched by...

10.1055/s-0039-1698409 article EN The Thoracic and Cardiovascular Surgeon 2019-10-11

Background Due to globally increasing donor organ shortage, investigation of previously described risk factors for utilizing marginal hearts is needed. The aim this study was determine the impact elevated serum troponin I (TnI) levels on outcome after heart transplantation (HTx). Methods Between January 1996 and August 2013, 161 patients were reviewed TnI (&gt;0.3 ng/mL considered elevated), postoperative parameters, 30-day mortality, 1-, 3-, 5-year survival. Results in 45 (28.0%) donors....

10.1055/s-0037-1606363 article EN The Thoracic and Cardiovascular Surgeon 2017-09-18

Background: Acute type A aortic dissection (AAAD) has high mortality. Improvements in surgical technique have lowered mortality but postoperative functional status and decreased quality of life due to debilitating deficits remain concern. Our study aims identify preoperative conditions predictive undesirable outcome help guide perioperative management. Methods: We performed retrospective analysis 394 cases AAAD who underwent repair our institution between 2001 2018. combined endpoint...

10.3390/jcm10225370 article EN Journal of Clinical Medicine 2021-11-18

Background Acute aortic dissection type A (AADA) is one of the most life-threatening situations and surgical demanding procedures even today. Usually AADA develops spontaneously, but it can be related also to interventional procedures. Methods We analyzed data 14 patients surgically treated in our institution with catheter-induced (ciAADA) during coronary angiography between January 2004 December 2014. Data were compared overall this time period (n = 288). Results Nine female. Subjects...

10.1055/s-0036-1594290 article EN The Thoracic and Cardiovascular Surgeon 2016-12-13

Introduction: The BiVACOR Total Artificial Heart (TAH) replaces the failing heart with a durable and physiologically adaptive pump, which combines magnetic levitation rotary blood pump technology. has large clearances to minimize shear stress, generates pulse pressure via cyclic changes in speed, modulates total outflow based on physiological conditions. A single rotor design enables small size. Aim: Primary endpoint was survival at 30 days normal end-organ function absence of device related...

10.1161/circ.148.suppl_1.16713 article EN Circulation 2023-11-07

Objectives: Patients in cardiogenic shock (CS) may be successfully bridged using intravascular micro-axial left ventricular assist devices (M-LVADs) for recovery or determination of definitive therapy. Methods: One hundred and seven CS patients implanted with M-LVADs from January 2020 to May 2024 were divided into four groups; group-1: 34 (transplant); group-2: 25 (LVAD); group-3: 42 (postcardiotomy (PCCS)); group-4: 6 (decision/recovery but excluded analysis). Multivariable logistic...

10.3390/jcm13226804 article EN Journal of Clinical Medicine 2024-11-12

Background: Primary graft dysfunction (PGD) is devastating. Amiodarone therapy prior to cardiac transplantation (TxP) common but has recently been reported as potential cause of PGD. Case: 66-year-old male with non-ischemic cardiomyopathy, severely reduced LVEF LVAD, recurrent VT on amiodarone for 6 months presented ICD shocks. was increased due storm in the setting Rhinovirus infection. Infusions and lidocaine were started repeat IV boli needed. VT-ablation not feasible multiple...

10.1161/circ.146.suppl_1.9457 article EN Circulation 2022-11-08

Patients with left ventricular assist devices (LVADs) who develop stage IV sacral pressure sores (SPS) have an increased procedural risk. We present the complications, including severe intra- and postoperative bleeding, diarrhea metabolic acidosis, volume loss acute on chronic renal failure, flap dehiscence late LVAD outflow cannula thrombosis, in a 54-year-old male underwent diverting ileostomy (DI) subsequent fasciocutaneous (FCF) surgery for SPS while supported LVAD. Our experience...

10.1177/0267659114560043 article EN Perfusion 2014-11-06

Objective: Clinical benefit of mitral valve reconstruction (MVR) is well documented, but comparative data long term follow-up (> 12 months period) in postoperative quality life (QoL) and mental power are missing. We hypothesised that with isolated disease have neuropsychological benefits 1-years follow-up.

10.1055/s-0034-1367412 article EN The Thoracic and Cardiovascular Surgeon 2014-02-10

Objectives: Donor selection remains a critical yet poorly standardized aspect of heart transplantation (HTx). The aim this study was to determine whether elevated donor cardiac serum marker troponin I (cTnI) is associated with graft failure after HTx.

10.1055/s-0035-1544417 article EN The Thoracic and Cardiovascular Surgeon 2015-01-20

Objectives: Advanced age is an established independent risk factor for significant morbidity and mortality after coronary artery bypass grafting (CABG). Minimized extracorporeal circulation (MECC) has been shown to reduce the negative effects associated with conventional (CECC). This trial aimed evaluate impact of MECC on outcome septua- octogenarians undergoing CABG surgery.

10.1055/s-0035-1544471 article EN The Thoracic and Cardiovascular Surgeon 2015-01-20

Introduction: Veno- arterial extracorporeal life support (ECLS) is an established method to stabilize acute circulatory failure by providing immediate gas exchange and peripheral tissue perfusion. Parameters data on when ideally wean are limited. Hypothesis: Bilirubin levels may serve as indicator for readiness ECLS. The purpose of this study was evaluate the impact dynamic changes elevated bilirubin survival in a large patient population Methods: We reviewed 502 consecutive cases ECLS from...

10.1161/circ.134.suppl_1.11819 article EN Circulation 2016-11-11
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