A5055667657- Environmental Toxicology and Ecotoxicology
- Erythrocyte Function and Pathophysiology
- Sperm and Testicular Function
- Pharmaceutical and Antibiotic Environmental Impacts
- Reproductive biology and impacts on aquatic species
- Microplastics and Plastic Pollution
- Nanoparticles: synthesis and applications
- Lipid Membrane Structure and Behavior
- Blood properties and coagulation
- Animal Genetics and Reproduction
- Connexins and lens biology
- Advanced biosensing and bioanalysis techniques
- Reproductive Biology and Fertility
- Cellular Mechanics and Interactions
- Physiological and biochemical adaptations
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Spectroscopy Techniques in Biomedical and Chemical Research
- Photoreceptor and optogenetics research
- Liver Disease Diagnosis and Treatment
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Graphene and Nanomaterials Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA Research and Splicing
University of Naples Federico II
2015-2025
ENEA Portici Research Centre
2011
National Agency for New Technologies, Energy and Sustainable Economic Development
2011
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
1993-1997
The purpose of the present study was to examine short-term effect high-fat or high-fat-high-fructose feeding on hepatic lipid metabolism and mitochondrial function in adult sedentary rats. Adult male rats were fed a diet for 2 weeks. Body liver composition, steatosis, plasma profile insulin sensitivity, together with whole-body de novo lipogenesis, assessed. Hepatic mass, functionality, oxidative stress antioxidant defense also measured. Rats exhibited significantly higher triglycerides,...
The increase in the use of refined food, which is rich fructose, particular concern children and adolescents, since total caloric intake prevalence metabolic syndrome are increasing continuously these populations. Nevertheless, effects high fructose diet have been mostly investigated adults, by focusing on effect a long-term intake. Notably, some reports evidenced that even short-term exerts detrimental metabolism. Therefore, aim this study was to compare changes induced fructose-rich rats...
The use of quantum dots (QDs) for nanomedicine is hampered by their potential toxicologic effects and difficulties with delivery into the cell interior. We accomplished an in vivo study exploiting Daphnia magna Xenopus laevis to evaluate both toxicity uptake QDs coated membranotropic peptide gH625 derived from glycoprotein H herpes simplex virus widely used drug studies. evaluated compared gH625-QDs on survival, uptake, induction several responsive pathways genotoxicity D. magna, we found...
During an infection, a single or multispecies biofilm can develop. Infections caused by non-dermatophyte molds, such as Fusarium spp. and yeasts, Candida spp., are particularly difficult to treat due the formation of mixed two species. oxysporum is responsible for approximately 20% human fusariosis, while albicans superficial mucosal dermal infections disseminated bloodstream with mortality rate above 40%. This study aims investigate interactions between C. F. dual-species biofilm,...
This work illustrates a new role for the membranotropic peptide gH625 and its derivative gH625-GCGKKK in impairing formation of polymicrobial biofilms. Mixed biofilms composed Candida bacterial species cause frequently infections failure medical silicone devices also show major drug resistance than single-species Inhibition eradication were evaluated by complementary methods: XTT-reduction, crystal violet staining (CV). Our results indicate that gH625-GCGKKKK, better native peptide, strongly...
Although oocyte cryopreservation has great potentials in the field of reproductive technologies, it still is an open challenge majority domestic animals and little known on biochemical transformation induced by this process different cellular compartments. Raman micro-spectroscopy allows non-invasive evaluation molecular composition cells, based inelastic scattering laser photons vibrating molecules. The aim work was to assess modifications both zona pellucida cytoplasm vitrified/warmed...
Psychotropic drugs and benzodiazepines are nowadays among the primary substances of abuse. This results in a large constant release into aquatic environments where they have potentially harmful effects on non-target organisms and, eventually, human health. In last decades, evidence has been collected possible interference with reproductive processes, but data few incomplete. this study, negative influence delorazepam fertilization embryo development tested Paracentrotus lividus, key model...
Anthropic activities have significantly elevated cadmium levels, making it a significant stressor in aquatic ecosystems. Present high concentrations across water bodies, is known to bioaccumulate and biomagnify throughout the food chain. While toxic effects of on organs tissues species are well-documented, little about its impact sensory systems crucial for survival. Consequently, this study investigated short-term exposure (96 h) 25 µM chloride olfactory system adult zebrafish. The research...
chlorpyrifos (CPF) is an organophosphate insecticide used to control pests on a variety of food and feed crops. In mammals, maternal exposure CPF has been reported induce cerebral cortex thinning, alteration long-term brain cognitive function, Parkinson-like symptoms, but the mechanisms these processes are not fully understood. this study, we aimed gain deeper understanding alterations induced in brains mice chronically exposed by dietary intake. For our purpose, analysed F1 offspring...
Chlorpyrifos (CPF) is an organophosphate insecticide used primarily to control foliage and soil‐borne insect pests on a variety of food feed crops. In mammals, maternal exposure CPF has been reported induce dose‐related abnormalities such as slower brain growth cerebral cortex thinning. lower vertebrates, for example, fish amphibians, teratogenic activity this compound correlated with several anatomical alterations. Little known about the effects mRNA expression genes involved in early...
We have used ratiometric confocal microscopy and three fluorescence techniques to study the distribution activity of mitochondria in frog oocytes during early stages oogenesis. Mitochondria oogenesis were characterised by a high ratio ‘mitochondrial cloud’ peri-nuclear region low freely dispersed within cytoplasm. tested whether visualised represented mitochondrial membrane potential perturbing potential. Carbonyl cyanide p -(trifluoromethyl)phenylhydrazone (FCCP) caused immediate...