A5052104966- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Gut microbiota and health
- Probiotics and Fermented Foods
- Spaceflight effects on biology
- Biochemical effects in animals
- Mitochondrial Function and Pathology
- Metabolism, Diabetes, and Cancer
- Planetary Science and Exploration
- Biochemical Analysis and Sensing Techniques
- Muscle metabolism and nutrition
- Space Science and Extraterrestrial Life
- Tryptophan and brain disorders
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Clostridium difficile and Clostridium perfringens research
- Fatty Acid Research and Health
- Protein Kinase Regulation and GTPase Signaling
- Endoplasmic Reticulum Stress and Disease
- FOXO transcription factor regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Cholesterol and Lipid Metabolism
- Effects and risks of endocrine disrupting chemicals
University of Naples Federico II
2015-2025
University of Gothenburg
2019-2024
Federico II University Hospital
2015-2019
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2013
A fructose-rich diet can induce metabolic syndrome, a combination of health disorders that increases the risk diabetes and cardiovascular diseases. Diet is also known to alter microbial composition gut, although it not clear whether such alteration contributes development syndrome. The aim this work was assess possible link between gut microbiota diet-induced syndrome in rat model obesity. Rats were fed either standard or high-fructose diet. Groups fructose-fed rats treated with antibiotics...
Evidence indicates that many forms of fructose-induced metabolic disturbance are associated with oxidative stress and mitochondrial dysfunction. Mitochondria prominent targets damage; however, it is not clear whether DNA (mtDNA) damage and/or its lack repair events involved in disease resulting from a fructose-rich diet. In the present study, we evaluated degree to liver mtDNA repair, addition state antioxidant defense rats fed high-fructose We used male feeding on or control diet for eight...
The purpose of the present study was to examine short-term effect high-fat or high-fat-high-fructose feeding on hepatic lipid metabolism and mitochondrial function in adult sedentary rats. Adult male rats were fed a diet for 2 weeks. Body liver composition, steatosis, plasma profile insulin sensitivity, together with whole-body de novo lipogenesis, assessed. Hepatic mass, functionality, oxidative stress antioxidant defense also measured. Rats exhibited significantly higher triglycerides,...
Objective: The link between metabolic derangement of the gut-2013liver-visceral white adipose tissue (v-WAT) axis and gut microbiota was investigated. Methods: Rats were fed a fructose-rich diet treated with an antibiotic mix. Inflammation measured in portal plasma, ileum, liver, v-WAT, while insulin signalling analysed by measuring levels phosphorylated kinase Akt. function oxidative status hepatic mitochondria caecal composition also evaluated. Results: Ileal inflammation, increase plasma...
High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes cardiovascular diseases. The harmful effects of a high diet could be different, depending on dietary quality. In fact, diets rich in unsaturated fatty acids considered less deleterious human health than those saturated fat. our previous studies, we have shown that rats fed developed exhibited decrease oxidative capacity increase stress liver mitochondria. To investigate...
The increase in the use of refined food, which is rich fructose, particular concern children and adolescents, since total caloric intake prevalence metabolic syndrome are increasing continuously these populations. Nevertheless, effects high fructose diet have been mostly investigated adults, by focusing on effect a long-term intake. Notably, some reports evidenced that even short-term exerts detrimental metabolism. Therefore, aim this study was to compare changes induced fructose-rich rats...
In the present study, effect of long-term fructose feeding on skeletal muscle mitochondrial energetics was investigated. Measurements in isolated tissue were coupled with determination whole-body energy expenditure and insulin sensitivity. A significant increase plasma NEFA, as well TAG ceramide, found fructose-fed rats compared controls, together a significantly higher response to glucose load, while no variation levels found. Significantly lower RMR values starting from week 4 dietary...
Abstract Endogenous reactive oxygen species (ROS) are by-products of the aerobic metabolism cells and have an important signalling role as secondary messengers in various physiological processes, including cell growth development. However, excessive production ROS, well exposure to exogenous can cause protein oxidation, lipid peroxidation DNA damages leading injuries. ROS accumulation has been associated development health disorders such neurodegenerative cardiovascular diseases,...
Abstract Background Spore-forming bacteria of the Bacillus genus are widely used probiotics known to exert their beneficial effects also through stimulation host immune response. The oral delivery B. toyonensis spores has been shown improve response a parenterally administered viral antigen in mice, suggesting that may increase efficiency systemic vaccines. We C fragment tetanus toxin (TTFC) as model evaluate whether treatment with affected mucosal antigen. Results Purified TTFC was given...
Bisphenol A (BPA) is an organic chemical compound widely used for manufacturing plastics. BPA exposure originates principally from the diet, but it can also originate dermal contact. In over 90% of individuals, including pregnant women, detectable in several body fluids. The effects this on fetus are under active investigation research laboratories. aim our work was to study impact prenatal liver rat fetuses a sex-dependent point view. We particularly investigated hepatic lipids because...
Dietary high fructose (HFrD) is known as a metabolic disruptor contributing to the development of obesity, diabetes, and dyslipidemia. Children are more sensitive sugar than adults due distinct profile, therefore it especially relevant study alterations induced by HFrD mechanisms underlying such changes in animal models different ages. Emerging research suggests fundamental role epigenetic factors microRNAs (miRNAs) tissue injury. In this perspective, aim present was investigate involvement...
Dietary fats and sugars were identified as risk factors for overweight neurodegeneration, especially in middle-age, an earlier stage of the aging process. Therefore, our aim was to study metabolic response both white adipose tissue brain middle aged rats fed a typical Western diet (high saturated fructose, HFF) verify whether similarity exists between two tissues. Specific cyto/adipokines (tumor necrosis factor alpha (TNF-α), adiponectin), critical obesity-inflammatory markers (haptoglobin,...
Young age is often characterized by high consumption of processed foods and fruit juices rich in fructose, which, besides inducing a tendency to become overweight, can promote alterations brain function. The aim this study was therefore (a) clarify effects resulting from fructose juvenile age, critical phase for development, (b) verify whether these be rescued after removing the diet. rats were fed fructose-rich or control diet 3 weeks. Fructose-fed then further We evaluated mitochondrial...
Introduction Microencapsulation of probiotic bacteria is an efficient and innovative new technique aimed at preserving bacterial survival in the hostile conditions gastrointestinal tract. However, understanding whether a microcapsule preserves effectiveness bacterium contained within it fundamental importance. Methods Male Wistar rats aged 90 days were fed control diet or Western for 8 weeks, with divided into three groups: one receiving only (W), second group free L. reuteri DSM 17938 (WR),...
The consumption of western diets, high in fats and sugars, is a crucial contributor to brain molecular alterations, cognitive dysfunction neurodegenerative diseases. Therefore, mandatory challenge the individuation strategies capable preventing diet-induced impairment physiology. A promising strategy might consist administration probiotics that are known influence function via gut-brain axis. In this study, we explored whether Limosilactobacillus reuteri DSM 17938 (L. reuteri)-based approach...