A5025337373- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Dietary Effects on Health
- Protein Kinase Regulation and GTPase Signaling
- Retinal Development and Disorders
- Congenital heart defects research
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- RNA and protein synthesis mechanisms
- Pancreatic function and diabetes
- Cellular transport and secretion
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
University of Gothenburg
2019-2024
Heidelberg University
2023
Heidelberg University
2023
Southern University of Science and Technology
2023
ABSTRACT The formation of mammalian synapses entails the precise alignment presynaptic release sites with postsynaptic receptors but how nascent cell–cell contacts translate into assembly specializations remains unclear. Guided by pioneering work in invertebrates, we hypothesized that synapses, liprin-α proteins directly link trans -synaptic initial to downstream steps. Here show that, human neurons lacking all four isoforms, synaptic are formed recruitment active zone components and...
Insulin-PI3K signaling controls insulin secretion. Understanding this feedback mechanism is crucial for comprehending how functions. However, the role of adipocyte insulin-PI3K in controlling secretion vivo remains unclear. Using adipocyte-specific PI3Kα knockout mice (PI3Kα
The kinase PI3Kγ aggravates obesity by activating macrophages and triggering inflammation in adipose tissue.
Abstract Hepatoma cell lines are widely used to model the hepatocyte for insulin signaling and fatty liver disease. However, a direct comparison of action in primary hepatocytes hepatoma is needed validate this better understand cancer. Here we have investigated signaling, gluconeogenic gene expression, glucose production, acid synthase abundance HepG2, Hepa 1–6, McARH7777 lines. Differences electrophoretic profiles protein extracts from human mouse cells shown. Compared hepatocytes, showed...
Abstract Ribonuclease inhibitor 1, also known as angiogenin encoded by RNH1 , is a ubiquitously expressed leucine-rich repeat protein, which highly conserved in mammalian species. Inactivation of rnh1 mice causes an embryonically lethal anemia, but the exact biological function humans remains unknown and no human genetic disease has so far been associated with . Here, we describe family two out seven siblings affected characterized congenital cataract, global developmental delay, myopathy...
SUMMARY Insulin secretion is governed by insulin-PI3K signaling. Resolving the mechanism of this feedback necessary to understand how insulin operates. Mice lacking receptor, or AKT1 and AKT2 in adipocytes, are severely lipoatrophic. Thus, role adipocyte signaling control remains unknown. Using adipocyte- specific PI3Kα knockout mice (PI3Kα AdQ ) a panel isoform-selective PI3K inhibitors, we have found that PI3Kβ activities functionally redundant PI3Kβ-selective inhibitors had no effect on...
Abstract Inhibitors of insulin-PI3K signaling potently induce insulin secretion in-vivo, demonstrating that is governed by feedback control. Resolving the mechanism this necessary to understand hyperinsulinemia and resistance develop optimal PI3K-targeted therapies. Adipose tissue-specific knockout mice for receptor, or AKT1 AKT2, are severely lipodystrophic. Thereby, role adipocyte in control remains unknown. To investigate vivo, we generated adipocyte-specific PI3Ka (PI3Ka AdQ ). F/F...
Abstract The kinase IKKβ controls pro‐inflammatory gene expression, and its activity in the liver leukocytes was shown to drive metabolic inflammation insulin resistance obesity. However, it also proposed that signaling protects obese mice from endoplasmic reticulum (ER) stress by increasing XBP1s protein stability. Furthermore, lacking display increased lethality lipopolysaccharides. This study aims at improving our understanding of role We induced deletion hematopoietic cells Cre‐LoxP...
<title>Abstract</title> Formation of mammalian synapses entails the precise alignment presynaptic release sites with postsynaptic receptors but how nascent cell-cell contacts translate into assembly specializations remains unclear. Guided by pioneering work in invertebrates, we hypothesized that synapsesLiprin-α proteins directly link trans-synapticinitial to downstream steps. In human neurons lacking all four Liprin-α isoforms, synaptic are formed recruitment active zone components and...